NEOADJUVANT CHEMOTHERAPY IN NON-SMALL CELL LUNG CANCER (NSCLC): CURRENT STATUS
https://doi.org/10.18027/2224-5057-2014-3-22-29
Abstract
The role of neoadjuvant chemotherapy in NSCLC still remains unclear. It may be useful in the treatment of resectable NSCLC like in other solid tumors. Only prospective studies will answer this question. Determination of optimal candidates for comparative studies of preoperative and postoperative chemotherapy in practice is a challenge. The best approach for patients with I and II stages of NSCLC is to provide combined treatment including surgery and adjuvant chemotherapy, and for patients with borderline resectable tumors with stages IIB, IIIA, but with minimal or without involvement of mediastinal lymph nodes is to provide neoadjuvant chemotherapy. For today, traditional ways of improving chemotherapy of NSCLC are exhausted, however, in connection with the development of recombinant cytokines (available for Phase I clinical trials), it opened real possibilities for clinical research on the development and evaluation of methods of neoadjuvant chemoimmunotherapy of NSCLC.
About the Authors
Yuri N. Lazutin
Ростовский научно-исследовательский онкологический институт, г. Ростов-на-Дону
Russian Federation
Russian Federation
Sergei P. Pyltsin
Ростовский научно-исследовательский онкологический институт, г. Ростов-на-Дону
Russian Federation
Russian Federation
Anna P. Kharitonova
Ростовский научно-исследовательский онкологический институт, г. Ростов-на-Дону
Russian Federation
Russian Federation
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Review
For citations:
Lazutin Yu.N., Pyltsin S.P., Kharitonova A.P. NEOADJUVANT CHEMOTHERAPY IN NON-SMALL CELL LUNG CANCER (NSCLC): CURRENT STATUS. Malignant tumours. 2014;(3):22-29. (In Russ.) https://doi.org/10.18027/2224-5057-2014-3-22-29
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