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Злокачественные опухоли

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СПОРНЫЕ ВОПРОСЫ АДЪЮВАНТНОЙ ХИМИОТЕРАПИИ РАКА ПРЯМОЙ КИШКИ ВТОРОЙ СТАДИИ

https://doi.org/10.18027/2224-5057-2014-3-132-136

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Аннотация

При II и III стадии рака прямой кишки (cT3/сТ 4 или cN+) в большинстве случаях стандартным подходом в лечебной тактике является сочетание хирургического и предоперационного  химиолучевого лечения. Такой подход позволяет значимо снизить частоту рецидивов болезни, а в некоторых исследованиях  приводит к улучшению общей выживаемости.  Однако в течение последующих 10 лет от 30% при  IIa до 70% больных  при IIIc стадии погибают от прогрессирования  болезни.  При этом прогрессирование  заболевания  у большинства реализуется  через отдаленное метастазирование,  что диктует необходимость совершенствования системной терапии. Основным методом профилактики отдаленного метастазирования  при ранних стадиях болезни является адъювантная химиотерапия. Однако к настоящему времени данные об эффективности  послеоперационного  лечения при раке прямой кишки после предоперационной  химиолучевой терапии остаются противоречивыми. Настоящий обзор литературы посвящен анализу результатов исследований, посвященных оценке эффективности адъювантной химиотерапии у больных раком прямой кишки после проведенного предоперационного  лечения при II стадии болезни.

Об авторе

М. Ю. Федянин
Российский онкологический научный центр им. Н. Н. Блохина
Россия

Контактная информация: Федянин Михаил Юрьевич (Fedyanin Mikhail), кандидат медицинских наук,  врач-онколог отделения клинической фармакологии и химиотерапии ФГБНУ «Российский онкологический центр имени  Н. Н. Блохина», +7 (905) 704–33–18, fedianinmu@mail.ru.



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Для цитирования:


Федянин М.Ю. СПОРНЫЕ ВОПРОСЫ АДЪЮВАНТНОЙ ХИМИОТЕРАПИИ РАКА ПРЯМОЙ КИШКИ ВТОРОЙ СТАДИИ. Злокачественные опухоли. 2014;(3):132-136. https://doi.org/10.18027/2224-5057-2014-3-132-136

For citation:


Fedyanin M.Y. CONTROVERSIAL ISSUES OF ADJUVANT CHEMOTHERAPY OF STAGE II COLORECTAL CANCER. Malignant tumours. 2014;(3):132-136. (In Russ.) https://doi.org/10.18027/2224-5057-2014-3-132-136

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ISSN 2224-5057 (Print)
ISSN 2587-6813 (Online)