Can the androgen receptor blocking become the basis of a new method of treatment of triple negative breast cancer?
https://doi.org/10.18027/2224-5057-2017-1-18-25
Abstract
Triple-negative breast cancer (TNBC) represents approximately 15% –20% of all diagnosed breast cancers. This tumor subtype characterized by the absence of expression of the estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor (HER2) protein. Tumor heterogeneity of triple negative breast cancer is the main barrier in the treatment of this tumor subtype. Although estrogen receptor (ER) and human epidermal growth factor receptor (HER2) are the mainstay therapeutic targets in breast cancer, the androgen receptor (AR) is evolving as a molecular target for cancers that have developed resistance to conventional treatments.
About the Authors
E. K. ZILTSOVA
Research Institute of oncology named after N. N. Petrov
Russian Federation
MD, PhD
Russian Federation
MD, PhD
O. A. IVANOVA
Research Institute of oncology named after N. N. Petrov
Russian Federation
MD, PhD
Russian Federation
MD, PhD
P. V. KRIVOROTKO
Research Institute of oncology named after N. N. Petrov
Russian Federation
MD, PhD, DSc
Russian Federation
MD, PhD, DSc
V. G. IVANOV
Research Institute of oncology named after N. N. Petrov
Russian Federation
MD, PhD
Russian Federation
MD, PhD
E. V. CYRLINA
Research Institute of oncology named after N. N. Petrov
Russian Federation
MD, PhD
Russian Federation
MD, PhD
G. A. DASHYAN
Research Institute of oncology named after N. N. Petrov
Russian Federation
MD, PhD, DSc
Russian Federation
MD, PhD, DSc
T. T. TABAGUA
Research Institute of oncology named after N. N. Petrov
Russian Federation
MD, PhD
Russian Federation
MD, PhD
K. S. NIKOLAEV
Research Institute of oncology named after N. N. Petrov
Russian Federation
MD, PhD
Russian Federation
MD, PhD
L. P. GIGOLAEVA
Research Institute of oncology named after N. N. Petrov
Russian Federation
postgraduate
Russian Federation
postgraduate
V. F. SEMIGLAZOV
Research Institute of oncology named after N. N. Petrov
Russian Federation
MD, PhD, DSc
Russian Federation
MD, PhD, DSc
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Review
For citations:
ZILTSOVA E.K., IVANOVA O.A., KRIVOROTKO P.V., IVANOV V.G., CYRLINA E.V., DASHYAN G.A., TABAGUA T.T., NIKOLAEV K.S., GIGOLAEVA L.P., SEMIGLAZOV V.F. Can the androgen receptor blocking become the basis of a new method of treatment of triple negative breast cancer? Malignant tumours. 2017;(1):18-25. (In Russ.) https://doi.org/10.18027/2224-5057-2017-1-18-25
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