Стволовые опухолевые клетки рака толстой кишки
Аннотация
Ранее механизм канцерогенеза рака толстой кишки представлялся процессом последовательного накопления аберраций в генах APC, TP53, TGF , активации сигнального пути MAPK [1]. Это клинически реализовалось в формировании аденомы с последующей трансформацией в злокачественную опухоль. Однако к настоящему времени показано генетическое разнообразие аденокарцином толстой кишки, каждый подтип которой развивается по своему определенному генетически и/или эпигенетически опосредованному пути канцерогенеза [2]. В последнее десятилетие все чаще появляются работы, посвященные теории стволовых опухолевых клеток – только небольшая фракция опухолевых клеток способна инницировать рост опухоли. Данные клетки способны не только дифференцироваться в более зрелые формы опухолевых клеток, но и поддерживают собственный пул клеток – способность к самообновлению [3]. Кроме этого, данные клетки отличаются большей резистентностью к химиотерапии.
Об авторах
Михаил Юрьевич Федянин
ФГБУ «Российский онкологический научный центр им. Н. Н. Блохина»
Россия
Россия
к. м.н., врач-онколог отделения клинической фармакологии и химиотерапии,
г. Москва
Дарья Николаевна Хмелькова
МФТИ
Россия
Россия
н. с. лаборатории трансляционных исследований и персонализированной медицины Центра живых систем,
Московская область, г. Долгопрудный
Татьяна Сауловна Серебрийская
МФТИ
Россия
Россия
к. б.н., с. н.с. лаборатории трансляционных исследований и персонализированной медицины Центра живых систем,
Московская область, г. Долгопрудный
Татьяна Анатольевна Никольская
МФТИ
Россия
Россия
к. б.н., зав. лабораторией трансляционных исследований и персонализированной медицины Центра живых систем,
Московская область, г. Долгопрудный
Сергей Алексеевич Тюляндин
ФГБУ «Российский онкологический научный центр им. Н. Н. Блохина»
Россия
Россия
д. м.н., профессор, зав. отделением клинической фармакологии и химиотерапии,
г. Москва
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Рецензия
Для цитирования:
Федянин М.Ю., Хмелькова Д.Н., Серебрийская Т.С., Никольская Т.А., Тюляндин С.А. Стволовые опухолевые клетки рака толстой кишки. Злокачественные опухоли. 2015;(4s2):71-81.
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