Механизмы развития и пути преодоления эндокринной резистентности при раке молочной железы


https://doi.org/10.18027/2224-5057-2015-4-52-61

Полный текст:


Аннотация

Около 70% случаев рака молочной железы (РМЖ) представляют собой гормон-чувствительные опухоли, и основным методом лечения таких опухолей является антиэстрогеновая терапия. На данный момент времени, существенной проблемой остается развитие эндокринной резистентности при применении гормонального лечения. В статье приведен обзор литературы о сигнальных путях, регулирующих опухолевый рост, механизмах развития эндокринной резистентности и о возможных путях ее преодоления.

Об авторах

Артур Альбертович Хисамов
ГБУЗ МКНЦ ДЗМ
Россия

врач-хирург,

г. Москва



Ольга Олеговна Мануйлова
ГБУЗ МКНЦ ДЗМ
Россия

зам. заведующего Клиники женского здоровья,

г. Москва



Михаил Юрьевич Бяхов
ГБУЗ МКНЦ ДЗМ
Россия

д.м.н., профессор, зам. директора по онкологии,

г. Москва



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Дополнительные файлы

Для цитирования: Хисамов А.А., Мануйлова О.О., Бяхов М.Ю. Механизмы развития и пути преодоления эндокринной резистентности при раке молочной железы. Злокачественные опухоли. 2015;(4):52-61. https://doi.org/10.18027/2224-5057-2015-4-52-61

For citation: Khisamov A.A., Manujlova O.O., Byakhov M.Y. Mechanisms of development and the ways to overcome endocrine resistance in breast cancer. Malignant tumours. 2015;(4):52-61. (In Russ.) https://doi.org/10.18027/2224-5057-2015-4-52-61

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