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Influence of Different Regimens of Prostate Cancer Androgen Deprivation on Metabolic Syndrome and Sexual Dysfunction

https://doi.org/10.18027/2224-5057-2015-4-48-51

Abstract

Androgen deprivation remains a golden standard therapy in advance Prostate cancer. Besides adequate suppression of the tumor growth, ADT causes temporary or even permanent sexual dysfunction along with the high risk of metabolic complications. In our prospective study we have included 56 patients with advanced forms of prostrate cancer and remained sexual activity whom were subjects to different regimens of ADT. The primary goal of our study was evaluation of the degree of metabolic complications and time to regain sexual activity using continuous and intermittent GnRH analogues therapy and sequential therapy with GnRH analogues and bicalutamide.

About the Authors

Sergey Vladimirovich Mishugin
Moscow City Hospital 57
Russian Federation

MD, PhD, chief of the department of oncological urology,

Moscow



Aleksandr Anatol’evich Gritzkevich
Moscow Insitute of Surgery named after A.V. Vishnevsky
Russian Federation

MD, PhD, department of urology,

Moscow



Anton Aleksandrovich Kosov
Moscow Research Institute of Urology named after N.A. Lopatkin
Russian Federation

MD, department of oncological urology,

Moscow



Igor' Georgievich Rusakov
Moscow Research Institute of Oncology named after P.A. Gertzen
Russian Federation

MD, PhD, DSc, professor, department of oncological urology,

Moscow



References

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6. Peter Iversen, Chris J Tyrrell, Amir V Kaisary et al. “Bicalutamide Monotherapy Compared with Castration in Patients with Nonmetastatic Locally Advanced prostate Cancer: 6.3 years of Followup” The Journal of Urology 2000 DOI: http://dx.doi.org/10.1016/S0022–5347(05)67032–2.


Review

For citations:


Mishugin S.V., Gritzkevich A.A., Kosov A.A., Rusakov I.G. Influence of Different Regimens of Prostate Cancer Androgen Deprivation on Metabolic Syndrome and Sexual Dysfunction. Malignant tumours. 2015;(4):48-51. (In Russ.) https://doi.org/10.18027/2224-5057-2015-4-48-51

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ISSN 2224-5057 (Print)
ISSN 2587-6813 (Online)