Retroperitoneal liposarcoma is a rare malignancy with a high recurrence rate. Giant retroperitoneal liposarcoma presents significant challenges for oncologists due to its invasive nature and compression of vital organs. Early diagnosis and complete surgical removal of the tumor are key factors in the successful treatment of this disease. This case demonstrates the complexity of treating a 65‑year‑old woman with a tumor measuring 31 × 26 × 17 cm, weighing 5.9 kg. It highlights the importance of precision and complexity of surgical intervention, as well as the potential of using 3D tumor modeling to calculate tumor volume, intraoperative blood loss, surgical planning, and predict complications.