Breast implant capsule‑associated squamous cell carcinoma: case report
https://doi.org/10.18027/2224-5057-2020-10-4-30-37
Abstract
Breast augmentation with the use of silicone breast implants is a routine practice for breast surgeons. Breast implant capsule‑associated squamous cell carcinoma is a rare and aggressive malignant tumor accounting for less than 0,1 % of invasive breast cancer. Currently there is no single concept of a complex therapy for such tumors due to the low incidence rate. The article describes a case of a 49‑year‑old female patient after surgical treatment of left‑sided breast implant capsule‑associated squamous cell carcinoma diagnosed in 2019. After the disease progression the patient underwent removal of the chest wall tumor with resection of ribs 3–5, allo‑and autoplasty, and left axillary lymph node dissection (ALND). In most cases, breast implant capsule‑associated squamous cell carcinoma is treated surgically but the role of adjuvant chemotherapy, radiation therapy, and endocrine therapy is still ambiguous.
About the Authors
A. D. ZikiryakhodzhaevRussian Federation
Azizzhon D. Zakiryakhodzhaev, Head of the Department of Oncology and Breast and Skin Reconstructive Plastic Surgery
Moscow
Sh. G. Khakimova
Uzbekistan
Shakhnoz. G. Khakimova, MD, PhD, Department of Breast and Skin Reconstructive Plastic Surgery
Moscow, Tashkent
E. A. Rasskazova
Russian Federation
Elena A. Rasskazova, MD, PhD, Researcher of the Department of Oncology and Breast and Skin Reconstructive Plastic Surgery
Moscow
E. K. Saribekyan
Russian Federation
Erik K. Saribekyan, MD, PhD, DSc, Leading Researcher of the Department of Oncology and Breast and Skin Reconstructive
Plastic Surgery
Moscow
D. F. Omarova
Russian Federation
Dzhanet F. Omarova, Postgraduate Student, of the Department of Oncology and Breast and Skin Reconstructive Plastic
Surgery
Moscow
V. S. Surkova
Russian Federation
Victoria S. Surkova, Pathologist, Department of Pathological Anatomy
Moscow
G. G. Khakimova
Uzbekistan
Gulnoz G. Khakimova, MD, PhD, oncologist
Tashkent
References
1. Paletta C, Paletta FX, Jr., Paletta FX, Sr. Squamous cell carcinoma following breast augmentation. Ann Plast Surg 1992; 29, 425–429; discussion 429–432
2. Molitor M, Mestak O, Kalinova L, Krajcova A, Mestak J. The history and safety of breast implants. Acta Chir Plast. 2014;56 (1-2):15–19.
3. Patrick J. Buchanan, Vinod K. Chopra, Kristen L. Walker Primary Squamous Cell Carcinoma Arising from a Breast Implant Capsule: A Case Report and Review of the Literature The American Society for Aesthetic Plastic Surgery –2018
4. SmithLF, SmithTT, YearyE, McGeeJM, MalnarK: Squamouscellcarcinomaofthebreast following silicone injection of the breasts. J Okla State Med Assoc. 1999, 92:126–130.
5. Barr LH, Menard JW: Marjolin’s ulcer. The LSU experience. Cancer. 1983, 52:173–175.10.1002/1097–0142 (19830701) 52:1<173::AID–CNCR2820520131>3.0. CO;2–6
6. Paletta C, Paletta FX Jr, Paletta FX Sr: Squamous cell carcinoma following breast augmentation. Ann Plast Surg. 1992, 29:425–429.
7. Satgunaseelan L, Cheung D, Reddy J: Breast implant-associated squamous cell carcinoma—a rare long term complication. Pathology. 2015, 47:72–73. 10.1097/01. PAT. 0000461520.64127.87
8. Zomerlei TA, Samarghandi A, Terando AM: Primary squamous cell carcinoma arising from a breast implant capsule. Plast Reconstr Surg Glob Open. 2015, 3:586. 10.1097/GOX. 0000000000000567
9. Olsen DL, Keeney GL, Chen B, Visscher DW, Carter JM: Breast implant capsule-associated squamous cell carcinoma: a report of 2 cases. Hum Pathol. 2017, 67:94–100. 10.1016/j. humpath. 2017.07.011
10. Zhou YM, Chaudhry HE, Shah A, Andrews J. Breast Squamous Cell Carcinoma Following Breast Augmentation. Cureus. 2018;10 (10):e3405. Published 2018 Oct 3. doi:10.7759/cureus. 3405
11. Handel N, Cordray T, Gutierrez J, Jensen JA: A long-term study of outcomes, complications, and patient satisfaction with breast implants. Plast Reconstr Surg. 2006, 117:757–767. 10.1097/01. prs. 0000201457.00772.1d
12. Rosen PP, Hoda SA, Brogi E, Koerner FC: Rosen’s Breast Pathology. Wolters Kluwer, Philadelphia; 2014.
13. Yadav S, Yadav D, Zakalik D: Squamous cell carcinoma of the breast in the United States: incidence, demographics, tumor characteristics, and survival. Breast Cancer Res Treat. 2017, 164:201–208. 10.1007/s10549–017–4251–3
14. Lakhani SR: WHO classification of tumours of the breast: [views of a working group that convened for a consensus and editorial meeting at the International Agency for Research on Cancer]. International Agency for Research on Cancer. World Health Organization, Lyon; 2012. 1:430.
15. SmithLF, SmithTT, YearyE, McGeeJM, MalnarK: Squamouscellcarcinomaofthebreast following silicone injection of the breasts. J Okla State Med Assoc. 1999, 92:126–130.
16. Anne N. Primary squamous cell carcinoma of the breast: a case report and review of the literature/N. Anne, E. Sulger, R. Pallapothu// J Surg Case Rep. –2019.—Vol. 6.—P. 182. doi:10.1093/jscr/rjz182
Review
For citations:
Zikiryakhodzhaev A.D., Khakimova Sh. ., Rasskazova E.A., Saribekyan E.K., Omarova D.F., Surkova V.S., Khakimova G.G. Breast implant capsule‑associated squamous cell carcinoma: case report. Malignant tumours. 2020;10(4):30-37. (In Russ.) https://doi.org/10.18027/2224-5057-2020-10-4-30-37