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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">tumors</journal-id><journal-title-group><journal-title xml:lang="ru">Malignant tumours</journal-title><trans-title-group xml:lang="en"><trans-title>Malignant tumours</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2224-5057</issn><issn pub-type="epub">2587-6813</issn><publisher><publisher-name>Rosoncoweb</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18027/2224-5057-2020-10-4-30-37</article-id><article-id custom-type="elpub" pub-id-type="custom">tumors-826</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ И АНАЛИТИКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS AND ANALYSIS</subject></subj-group></article-categories><title-group><article-title>Случай из практики: капсуло‑ассоциированный плоскоклеточный рак молочнойжелезы</article-title><trans-title-group xml:lang="en"><trans-title>Breast implant capsule‑associated  squamous cell carcinoma: case report</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зикиряходжаев</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Zikiryakhodzhaev</surname><given-names>A.  D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Азизжон Д. Зикиряходжаев, д. м. н., заведующий отделением онкологии и реконструктивно-пластической хирургии молочной железы и кожи</p><p>Москва</p></bio><bio xml:lang="en"><p>Azizzhon D. Zakiryakhodzhaev, Head of the Department of Oncology and Breast and Skin Reconstructive Plastic Surgery</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хакимова</surname><given-names>Ш. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Khakimova</surname><given-names>Sh.  G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шахноз Г. Хакимова, к. м. н., отделение реконструктивно-пластической хирургии молочной железы и кожи</p><p>Москва,  Ташкент</p></bio><bio xml:lang="en"><p>Shakhnoz. G. Khakimova, MD, PhD, Department of Breast and Skin Reconstructive Plastic Surgery</p><p> Moscow, Tashkent</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рассказова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rasskazova</surname><given-names>E.  A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елена А. Рассказова, к. м. н., научный сотрудник отделения онкологии и реконструктивно-пластической хирургии молочной железы и кожи</p><p>Москва</p></bio><bio xml:lang="en"><p>Elena A. Rasskazova, MD, PhD, Researcher of the Department of Oncology and Breast and Skin Reconstructive Plastic Surgery</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сарибекян</surname><given-names>Э. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Saribekyan</surname><given-names>E.  K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Эрик К. Сарибекян, д. м. н., ведущий научный сотрудник отделения онкологии и реконструктивно-пластической хирургии молочной железы и кожи</p><p> Москва</p></bio><bio xml:lang="en"><p>Erik K. Saribekyan, MD, PhD, DSc, Leading Researcher of the Department of Oncology and Breast and Skin Reconstructive Plastic Surgery</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Омарова</surname><given-names>Д. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Omarova</surname><given-names>D.  F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Джанет Ф. Омарова, аспирант отделения онкологии и реконструктивно-пластической хирургии молочной железы и кожи</p><p>Москва</p></bio><bio xml:lang="en"><p>Dzhanet F. Omarova, Postgraduate Student, of the Department of Oncology and Breast and Skin Reconstructive Plastic Surgery</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Суркова</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Surkova</surname><given-names>V.  S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Виктория С. Суркова, врач-патологоанатом отделения патологической анатомии</p><p>Москва</p></bio><bio xml:lang="en"><p>Victoria S. Surkova, Pathologist, Department of Pathological Anatomy</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хакимова</surname><given-names>Г. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Khakimova</surname><given-names>G.  G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гулноз Г. Хакимова, к.м.н., врач-онколог отделения химиотерапии Ташкентского городского филиала</p><p>Узбекистан</p></bio><bio xml:lang="en"><p>Gulnoz G. Khakimova, MD, PhD, oncologist</p><p>Tashkent</p></bio><email xlink:type="simple">hgg_doc@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>МНИОИ им. П. А. Герцена — филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>P. Hertzen Moscow Oncology Research Institute — Branch of the National Medical Research Radiological Centre</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>МНИОИ им. П. А. Герцена — филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России; Ташкентский педиатрический медицинский институт</institution><country>Узбекистан</country></aff><aff xml:lang="en"><institution>P. Hertzen Moscow Oncology Research Institute — Branch of the National Medical Research Radiological Centre;  Tashkent Pediatric Medical Institute</institution><country>Uzbekistan</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Ташкентский педиатрический медицинский институт; Республиканский специализированный Научно-практический Медицинский Центр Онкологии и Радиологии</institution><country>Узбекистан</country></aff><aff xml:lang="en"><institution>Tashkent Pediatric Medical Institute; Republican specialized Scientific and practical Medical Center of Oncology and Radiology</institution><country>Uzbekistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>07</day><month>07</month><year>2021</year></pub-date><volume>10</volume><issue>4</issue><fpage>30</fpage><lpage>37</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Зикиряходжаев А.Д., Хакимова Ш.Г., Рассказова Е.А., Сарибекян Э.К., Омарова Д.Ф., Суркова В.С., Хакимова Г.Г., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Зикиряходжаев А.Д., Хакимова Ш.Г., Рассказова Е.А., Сарибекян Э.К., Омарова Д.Ф., Суркова В.С., Хакимова Г.Г.</copyright-holder><copyright-holder xml:lang="en">Zikiryakhodzhaev A.D., Khakimova S. ., Rasskazova E.A., Saribekyan E.K., Omarova D.F., Surkova V.S., Khakimova G.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.malignanttumors.org/jour/article/view/826">https://www.malignanttumors.org/jour/article/view/826</self-uri><abstract><p>Выполнение аугментационной маммопластики молочных желез с использованием силиконовых эндопротезов является рутинной практикой онкомаммологов. Капсуло-ассоциированный плоскоклеточный рак молочной железы является редким и агрессивным злокачественным новообразованием, составляющим менее 0,1 % от инвазивного рака молочного железы.</p><p>До настоящего времени в связи с низкой заболеваемостью подобными опухолями не существует единой концепции в комплексном лечении данной патологии. В статье описывается случай лечения пациентки 49 лет после хирургического удаления капсуло-ассоциированного плоскоклеточного рака левой молочной железы в 2019 году. После прогрессирования заболевания спустя год пациентке выполнено удаление опухоли грудной стенки с резекцией 3–5 ребер, алло-и аутопластикой, подмышечной лимфаденэктомией (ЛАЭ) слева. В большинстве случаев, основным лечением капсуло-ассоциированного плоскоклеточного рака молочной железы является хирургическое вмешательство, однако роль адъювантной химиотерапии, лучевой терапии и эндокринотерапии все еще не однозначна.</p></abstract><trans-abstract xml:lang="en"><p>Breast augmentation with the use of silicone breast implants is a routine practice for breast surgeons. Breast implant capsule‑associated squamous cell carcinoma is a rare and aggressive malignant tumor accounting for less than 0,1 % of invasive breast cancer. Currently there is no single concept of a complex therapy for such tumors due to the low incidence rate. The article describes a case of a 49‑year‑old female patient after surgical treatment of left‑sided breast implant capsule‑associated squamous cell carcinoma diagnosed in 2019. After the disease progression the patient underwent removal of the chest wall tumor with resection of ribs 3–5, allo‑and autoplasty, and left axillary lymph node dissection (ALND). In most cases, breast implant capsule‑associated squamous cell carcinoma is treated surgically but the role of adjuvant chemotherapy, radiation therapy, and endocrine therapy is still ambiguous.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рак молочной железы</kwd><kwd>плоскоклеточныйрак молочнойжелезы</kwd><kwd>лимфаденэктомия</kwd><kwd>гистологическое  исследование</kwd><kwd>сетчатый имплантант</kwd><kwd>комбинированное лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>breast cancer</kwd><kwd>squamous cell breast cancer</kwd><kwd>lymph node dissection</kwd><kwd>histopathological examination</kwd><kwd>mesh  implant</kwd><kwd>combination therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Paletta C, Paletta FX, Jr., Paletta FX, Sr. Squamous cell carcinoma following breast augmentation. 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