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Злокачественные опухоли

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Микросателлитная нестабильность как уникальная характеристика опухолей и предиктор эффективности иммунотерапии

https://doi.org/10.18027/2224-5057-2019-9-4-59-69

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Аннотация

Дефицит системы репарации неспаренных оснований представляет собой уникальное молекулярное нарушение, встречающееся в большинстве видах опухолей и проводящее к формированию в них микросателлитной нестабильности (MSI). Возникновение гипермутированного фенотипа и связанная с ним высокая иммуногенность обуславливает в целом более благоприятный прогноз данных опухолей, а также высокую чувствительность к иммунотерапии ингибиторами контрольных точек иммунного ответа. В данной обзорной статье представлены современные представления по диагностике, прогностической и предиктивной значимости MSI при различных опухолях, а также об эффективности их иммунотерапии.

Об авторах

А. А. Трякин
ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России; НИИ онкологии Башкирского Государственного медицинского университета
Россия

Алексей А. Трякин, д. м. н., главный научный сотрудник отделения клинической фармакологии и химиотерапии
Москва



М. Ю. Федянин
ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России
Россия

Михаил Ю. Федянин, д. м. н., старший научный сотрудник отделения клинической фармакологии и химиотерапии
Москва



А. С. Цуканов
ФГБУ «ГНЦК им. А.Н. Рыжих» Минздрава России
Россия

Алексей С. Цуканов, д. м. н., заведующий кабинетом лабораторной генетики
Москва



Ю. А. Шелыгин
ФГБУ «ГНЦК им. А.Н. Рыжих» Минздрава России
Россия

Юрий А. Шелыгин, д. м. н., проф., академик РАН, директор
Москва



И. А. Покатаев
ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России
Россия

Илья А. Покатаев, к. м. н., старший научный сотрудник отделения клинической фармакологии и химиотерапии
Москва



Е. О. Игнатова
ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России
Россия

Екатерина О. Игнатова, к. м. н, старший научный сотрудник отделения клинической фармакологиии и химиотерапии
Москва



Г. Г. Хакимова
ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России
Россия

Гулноз Г. Хакимова, аспирант отделения химиотерапии и комбинированного лечения злокачественных опухолей
Москва



М. А. Фролова
ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России
Россия

Мона А. Фролова, к. м. н, старший научный сотрудник отделения клинической фармакологиии и химиотерапии
Москва



С. А. Тюляндин
ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России
Россия

Сергей А. Тюляндин, д. м. н., профессор, заместитель директора по научной работе, заведующий отделением клинической фармакологиии и химиотерапии
Москва



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Для цитирования:


Трякин А.А., Федянин М.Ю., Цуканов А.С., Шелыгин Ю.А., Покатаев И.А., Игнатова Е.О., Хакимова Г.Г., Фролова М.А., Тюляндин С.А. Микросателлитная нестабильность как уникальная характеристика опухолей и предиктор эффективности иммунотерапии. Злокачественные опухоли. 2019;9(4):59-69. https://doi.org/10.18027/2224-5057-2019-9-4-59-69

For citation:


Tryakin A.A., Fedyanin M.Y., Tsukanov A.S., Shelygin Y.A., Pokataev I.A., Ignatova E.O., Khakimova G.G., Frolova M.A., Tjulandin S.A. Microsatellite instability as a unique characteristic of tumors and a predictor of response to immune therapy. Malignant tumours. 2019;9(4):59-69. (In Russ.) https://doi.org/10.18027/2224-5057-2019-9-4-59-69

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ISSN 2224-5057 (Print)
ISSN 2587-6813 (Online)