Современные иммунологические биомаркеры рака толстой кишки
https://doi.org/10.18027/2224-5057-2018-8-4-50-58
Аннотация
В статье кратко описан механизм действия иммунотерапевтических препаратов, подавляющих активность «чекпоинтов» иммунного ответа CTLA-4 и PD-1. Приведены современные данные о клинической эффективности и преимуществах применения ниволумаба, пембролизумаба и атезолизумаба при колоректальном раке. Обобщена существующая доказательная база о потенциальной предиктивной и прогностической роли MSI-статуса и представлена информация о перспективах дальнейшего развития данного метода лекарственного лечения злокачественных опухолей.
Ключевые слова
лекарственная терапия,
иммунотерапия,
CTLA-4,
PD-1,
PD-L1,
чекпоинты,
ниволумаб,
пембролизумаб,
атезолизумаб,
биомаркеры,
эффективность
Об авторах
А. А. Трякин
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина»
Россия
д. м. н., с. н. с. отделения клинической фармакологии и химиотерапии
Россия
д. м. н., с. н. с. отделения клинической фармакологии и химиотерапии
Г. Г. Хакимова
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина»
Россия
аспирант отделения химиотерапии и комбинированного лечения злокачественных опухолей
Россия
аспирант отделения химиотерапии и комбинированного лечения злокачественных опухолей
Т. Н. Заботина
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина»
Россия
д. б. н., зав. централизованным клинико-лабораторным отделом
Россия
д. б. н., зав. централизованным клинико-лабораторным отделом
А. А. Борунова
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина»
Россия
к. м. н., с. н. с. лаборатории клинической иммунологии опухолей
Россия
к. м. н., с. н. с. лаборатории клинической иммунологии опухолей
О. А. Малихова
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина»
Россия
д. м. н., проф., зав. отделения эндоскопического
Россия
д. м. н., проф., зав. отделения эндоскопического
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Рецензия
Для цитирования:
Трякин А.А., Хакимова Г.Г., Заботина Т.Н., Борунова А.А., Малихова О.А. Современные иммунологические биомаркеры рака толстой кишки. Злокачественные опухоли. 2018;8(4):50-58. https://doi.org/10.18027/2224-5057-2018-8-4-50-58
For citation:
Tryakin A.A., Khakimova G.G., Zabotina T.N., Borunova A.A., Malikhova O.A. Modern views on immunological biomarkers of colon cancer. Malignant tumours. 2018;8(4):50-58. (In Russ.) https://doi.org/10.18027/2224-5057-2018-8-4-50-58
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