OLANZAPINE FOR THE PREVENTION AND TREATMENT OF CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING
https://doi.org/10.18027/2224-5057-2018-8-3-21-30
Abstract
Chemotherapy-induced nausea and vomiting (CINV) has tremendous negative impact on daily life of cancer patients and their quality of life. In this article we analyzed current clinical guidelines in preventive measures and treatment of CINV as well as efficacy of recommended standard regimens for CINV prevention in patients receiving high emetogenic chemotherapy (HEC). We summarized existing data about olanzapine – affordable antipsychotic agent with potent antiemetogenic activity which is quite useful for CINV prophylaxis in patients receiving HEC. We highlighted possible future directions for research of olanzapine in oncology and reasons that preclude integration of this drug in routine clinical practice in Russia.
About the Authors
A. A. Rumyantsev
N. N. Blokhin Russian Cancer Research Center.
Russian Federation
Russian Federation
Alexey A. Rumyantsev, MD, PhD student, Department of Clinical Pharmacology and Chemotherapy.
Moscow.
I. A. Pokataev
N. N. Blokhin Russian Cancer Research Center.
Russian Federation
Russian Federation
Ilya A. Pokataev, MD, PhD Med, Senior Researcher, Department of Clinical Pharmacology and Chemotherapy.
Moscow.
M. Yu. Fedyanin
N. N. Blokhin Russian Cancer Research Center.
Russian Federation
Russian Federation
Mikhail Yu. Fedyanin, MD, DSc Med, Senior Researcher, Department of Clinical Pharmacology and Chemotherapy.
Moscow.
A. S. Tjulandina
N. N. Blokhin Russian Cancer Research Center.
Russian Federation
Russian Federation
Alexandra S. Tjulandina, MD, PhD Med, Senior Researcher, Department of Clinical Pharmacology and Chemotherapy.
Moscow.
A. A. Tryakin
N. N. Blokhin Russian Cancer Research Center.
Russian Federation
Russian Federation
Aleksey A. Tryakin, MD, DSc Med, Principal Researcher, Department of Clinical Pharmacology and Chemotherapy.
Moscow.
S. A. Tjulandin
N. N. Blokhin Russian Cancer Research Center.
Russian Federation
Russian Federation
Sergey A. Tjulandin, MD, DSc Med, Professor, Head of the Department of Clinical Pharmacology and Chemotherapy.
Moscow.
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Review
For citations:
Rumyantsev A.A., Pokataev I.A., Fedyanin M.Yu., Tjulandina A.S., Tryakin A.A., Tjulandin S.A. OLANZAPINE FOR THE PREVENTION AND TREATMENT OF CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING. Malignant tumours. 2018;8(3):21-30. (In Russ.) https://doi.org/10.18027/2224-5057-2018-8-3-21-30
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