Морфологические особенности BRCA1‑ассоциированных опухолей
Аннотация
BRCA1‑ассоциированные новообразования представляют собой большую гетерогенную группу опухолей с различным фенотипом, клинической картиной и прогнозом. Наличие мутации BRCA1 позволяет использовать современные эффективные стратегии лекарственной терапии опухолей с использованием PARP-ингибиторов для достижения наилучших результатов лечения. Новообразования молочной железы и яичника у носителей мутаций BRCA1 возникают значительно чаще, чем опухоли иных локализаций. BRCA1‑ассоциированные карциномы имеют определенные морфологические особенности, которые позволяют рекомендовать пациентам проведение молекулярно-генетического исследования.
Об авторах
А. О. Иванцов
ФГБУ «Научно-исследовательский институт онкологии имени Н. Н. Петрова» Министерства здравоохранения РФ; ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Министерства здравоохранения РФ.
Россия
Россия
Р. А. Насыров
ФГБУ «Научно-исследовательский институт онкологии имени Н. Н. Петрова» Министерства здравоохранения РФ; ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Министерства здравоохранения РФ.
Россия
Россия
E. H. Имянитов
ФГБУ «Научно-исследовательский институт онкологии имени Н. Н. Петрова» Министерства здравоохранения РФ; ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Министерства здравоохранения РФ.
Россия
Россия
А. П. Соколенко
ФГБУ «Научно-исследовательский институт онкологии имени Н. Н. Петрова» Министерства здравоохранения РФ; ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Министерства здравоохранения РФ.
Россия
Россия
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Рецензия
Для цитирования:
Иванцов А.О., Насыров Р.А., Имянитов E.H., Соколенко А.П. Морфологические особенности BRCA1‑ассоциированных опухолей. Злокачественные опухоли. 2018;8(3s1):90-95.
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