A neuroendocrine tumor, paraganglioma presenting as plunging goiter
S. V. Mosin,
E. A. Tarabrin,
I. Yu. Feydorov,
M. S. Tigrov,
E. V. Lafishev,
L. P. Yakovleva,
M. A. Kropotov,
A. L. Petrova,
N. S. Glagolev https://doi.org/10.18027/2224-5057-2019-9-2-64-73
Abstract
This paper presents two rare case reports with one common feature. Patients with thyroid nodules, who had undergone a comprehensive clinical evaluation based on standard algorithms according to their preoperative diagnosis of “Multinodular goiter, grade II”, were scheduled for surgical treatment (thyroidectomy). Postoperative morphological examination revealed, however, the extremely rare neuroendocrine tumor paraganglioma that simulated multinodular goiter with tracheal compression. Our analysis of these clinical cases showed common systematic mistakes that were committed during conventional, standardized preoperative examination, resulting in certain difficulties in the treatment of these patients.
About the Authors
S. V. Mosin
N.E. Bauman Municipal Clinical Hospital No. 29 of the Department of Health of the City of Moscow; N.I. Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Competing Interests: no conflict of interest
Russian Federation
Sergey V. Mosin - MD, PhD, Chief Surgeon N.E. Bauman Municipal Clinical Hospital No. 29 of the Department of Health of the City of Moscow, Associate Professor, Department of Faculty Surgery No. 1, Faculty of Medicine, N.I. Pirogov RNRMU.
Moscow
Competing Interests: no conflict of interest
E. A. Tarabrin
N.V. Sklifosovsky Research Institute of Emergency Care of the Department of Health of the City of Moscow; European Medical Center (ЕМС)
Russian Federation
Competing Interests: no conflict of interest
Russian Federation
Evgeniy A Tarabrin - MD, PhD, Head Scientific Department of Emergency Thoracic and Abdominal Surgery N.V. Sklifosovsky RIE C.
Moscow
Competing Interests: no conflict of interest
I. Yu. Feydorov
A.S. Loginov Moscow Clinical Scientific Center of the Department of Health of the City of Moscow; I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation
Russian Federation
Competing Interests: no conflict of interest
Russian Federation
Ilya Yu. Feydorov - Research Associate Department of Endocrine and Metabolic Surgery A.S. Loginov Moscow Clinical Scientific Center of the Department of Health of the City of Moscow, Senior Laboratory Assistant A.I. Evdokimov MSU
Competing Interests: no conflict of interest
M. S. Tigrov
A.S. Loginov Moscow Clinical Scientific Center of the Department of Health of the City of Moscow
Russian Federation
Competing Interests: no conflict of interest
Russian Federation
Mikhail S. Tigrov - Research Fellow Department of Head and Neck Tumors A.S. Loginov MCSC
Competing Interests: no conflict of interest
E. V. Lafishev
European Medical Center (ЕМС)
Russian Federation
Competing Interests: no conflict of interest
Russian Federation
Elmurat V. Lafishev - Coloproctologist, SEMC.
MoscowCompeting Interests: no conflict of interest
L. P. Yakovleva
A.S. Loginov Moscow Clinical Scientific Center of the Department of Health of the City of Moscow
Russian Federation
Competing Interests: no conflict of interest
Russian Federation
Liliya P. Yakovleva - MD, PhD, Head Center for the Diagnosis and Treatment of Head and Neck Tumors A.S. Loginov MCSC
Competing Interests: no conflict of interest
M. A. Kropotov
A.S. Loginov Moscow Clinical Scientific Center of the Department of Health of the City of Moscow
Russian Federation
Mikhail A. Kropotov - MD, PhD, DSc, Leading Research Associate Center for the Diagnosis and Treatment of Head and Neck Tumors A.S. Loginov MCSC
Competing Interests: no conflict of interest
Russian Federation
Mikhail A. Kropotov - MD, PhD, DSc, Leading Research Associate Center for the Diagnosis and Treatment of Head and Neck Tumors A.S. Loginov MCSC
Competing Interests: no conflict of interest
A. L. Petrova
A.S. Loginov Moscow Clinical Scientific Center of the Department of Health of the City of Moscow; I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation
Russian Federation
Competing Interests: no conflict of interest
Russian Federation
Anastasiya L Petrova
Competing Interests: no conflict of interest
N. S. Glagolev
N.E. Bauman Municipal Clinical Hospital No. 29 of the Department of Health of the City of Moscow; I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation
Russian Federation
Competing Interests: no conflict of interest
Russian Federation
Nikolay S. Glagolev - MD, PhD, Surgeon, Head 1st Department of Surgery
Competing Interests: no conflict of interest
References
1. Carle, A., Krejbjerg, A. and Laurberg, P. (2014). Epidemiology of nodular goitre. Influence of iodine intake. Best Practice & Research Clinical Endocrinology & Metabolism, 28 (4), pp.465-479
2. Li, H., Li, X., Liu, J., Jin, L., Yang, F., Wang, J., Wang, O. and Gao, Y. (2017). Correlation between serum lead and thyroid diseases: papillary thyroid carcinoma, nodular goiter, and thyroid adenoma. International Journal of Environmental Health Research, 27 (5), pp.409-419
3. Smith, J., Chen, X., Schneider, D., Broome, J., Sippel, R., Chen, H. and Solorzano, C. (2013). Cancer after Thyroidectomy: A Multi-Institutional Experience with 1,523 Patients. Journal of the American College of Surgeons, 216 (4), pp.571-577
4. Cibas, E. and Ali, S. (2017). The 2017 Bethesda System for Reporting Thyroid Cytopathology. Thyroid, 27 (11), pp.1341-1346
5. Cannizzaro, M., Lo Bianco, S., Picardo, M., Provenzano, D. and Buffone, A. (2017). How to avoid and to manage postoperative complications in thyroid surgery. Updates in Surgery, 69 (2), pp.211-215
6. Surgical management of substernal goitres at a tertiary referral centre: A retrospective cohort study of 2,104 patients. (2016). International Journal of Surgery, 27, pp.46-52
7. Кэплин М. Нейроэндокринные опухоли: руководство для врачей // М.: Изд-во Практическая медицина, 2011. С 67-96
8. Neuroendocrine Tumors, Version 1.2015. (2015). Journal of the National Comprehensive Cancer Network, 13 (1), pp.78-108. doi: 10.6004/jnccn.2015.0011
9. Tsirlin, A., Oo, Y., Sharma, R., Kansara, A., Gliwa, A. and Banerji, M. (2014). Pheochromocytoma: A review. Maturitas, 77 (3), pp.229-238
10. Орел Н.Ф., Горбунова В.А., Дворниченко В.В., Емельянова Г.С., Кузьминов А.Е., Любимова Н.В., Маркович А.А., Орлова Р.В., Трифанов В.С. Практические рекомендации по лекарственному лечению нейроэндокринных опухолей желудочно-кишечного тракта и поджелудочной железы. Коллектив авторов: DOI: 10.18027/2224-5057-2017-7-3s2-395-403
11. O’Connor, D., Mahata, S., Taupenot, L., Mahata, M., Livsey Taylor, C., Kailasam, M., Ziegler, M. and Parmer, R. (2000). Chromogranin A in Human Disease. Advances in Experimental Medicine and Biology, pp.377-388.
Review
For citations:
Mosin S.V., Tarabrin E.A., Feydorov I.Yu., Tigrov M.S., Lafishev E.V., Yakovleva L.P., Kropotov M.A., Petrova A.L., Glagolev N.S. A neuroendocrine tumor, paraganglioma presenting as plunging goiter. Malignant tumours. 2019;9(2):64-73. (In Russ.) https://doi.org/10.18027/2224-5057-2019-9-2-64-73
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