Domestic experience of prevention and treatment of skin toxicity in patients with metastatic colorectal cancer receiving inhibitors of EGFR: the example of using of panitumumab
https://doi.org/10.18027/2224-5057-2013-3-42-50
Abstract
The results of the first national experience of skin toxicity correction in patients with metastatic colorectal cancer (mCRC) receiving EGRF-inhibitors shown on the example of using of Panitumumab. The collection and evaluation of the data were produced in the framework of the project of the working group on maintenance therapy of Russian society of clinical oncologists and chemotherapeutists (RUSSCO) to develop recommendations for the prevention and treatment of dermatological toxicity in patients receiving EGFR-inhibitors. The project involved 10 centers in Russia. In 58 patients receiving Panitumumab, the efficacy of prophylactic medication and symptomatic treatment of clinical manifestations of dermatological toxicity using available remedies was evaluated. The results confirm the effectiveness of preventive therapy. Optimal correction schemes of various manifestations of dermal toxicity were developed depending on the clinical manifestations and severity.
About the Authors
S. E. VarlamovaRussian Federation
E. V. Orlova
Russian Federation
V. V. Ptushkin
Russian Federation
L. V. Bolotina
Russian Federation
N. Yu. Antimonik
Russian Federation
L. Yu. Vladimirova
Russian Federation
Yu. M. Makeev
Russian Federation
N. M. Kozlova
Russian Federation
B. A. Berdov
Russian Federation
P. S. Feoktistova
Russian Federation
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Review
For citations:
Varlamova S.E., Orlova E.V., Ptushkin V.V., Bolotina L.V., Antimonik N.Yu., Vladimirova L.Yu., Makeev Yu.M., Kozlova N.M., Berdov B.A., Feoktistova P.S. Domestic experience of prevention and treatment of skin toxicity in patients with metastatic colorectal cancer receiving inhibitors of EGFR: the example of using of panitumumab. Malignant tumours. 2013;(3):42-50. (In Russ.) https://doi.org/10.18027/2224-5057-2013-3-42-50