Ixabepilone in modern therapy of resistant breast cancer
https://doi.org/10.18027/2224-5057-2018-8-1-55-60
Abstract
Ixabepilone is an epothilone analog, active as a cytotoxic agent due to its ability to stabilize microtubules of tumor cells. Currently ixabepiloneis approved for treatment of metastatic breast cancer in patients previously treated with taxanes and anthracyclines. In this article we analyzed existing data about its efficacy in preoperative and adjuvant treatment settings as well as in systemic therapy of metastatic breast cancer. We discussed a role of ixabepilone in contemporary treatment of this disease.
About the Authors
A. A. Rumyantsev
N. N. Blokhin Russian Cancer Research Center
Russian Federation
MD, PhD student, Department of Clinical Pharmacology and Chemotherapy
Russian Federation
MD, PhD student, Department of Clinical Pharmacology and Chemotherapy
V. G. Ivanov
N.N. Petrov Research Institute of Oncology
Russian Federation
MD, PhD, Researcher of the Department of Breast Tumors
Russian Federation
MD, PhD, Researcher of the Department of Breast Tumors
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Review
For citations:
Rumyantsev A.A., Ivanov V.G. Ixabepilone in modern therapy of resistant breast cancer. Malignant tumours. 2018;8(1):55-60. (In Russ.) https://doi.org/10.18027/2224-5057-2018-8-1-55-60
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