Results of treatment of patients with local recurrence of colon cancer.

Aim: to improve the results of treatment of patients with local recurrence of colon cancer and evaluate effectiveness of the combined treatment.
Materials and methods. From 1997 to 2012 in SRCC 71 consecutive patients underwent combined surgery for local recurrence of colon cancer. Of these patients 38 (53.5%) had surgical treatment with intraoperative intraperitoneal chemotherapy. Sixty-five (91.5%) patients had locally advanced recurrent tumor. Localization of local recurrence in patients who underwent combined operations, was as follows: in the area of colonic anastomosis - in 11 (15.5%) patients; in the bed of the removed tumor - in 19 (26.8%); in the area of colostomy - in 10 cases (14.1%); in the stump of distal colon after obstructive procedures - in 31 (43.6%) patients. Mean operative time was 270 ± 45 minutes and mean blood loss - 430 ± 80 ml.
Results. Postoperative complications were observed in 6 (9.8%) of 61 patients. There was no mortality. Sixty-four (90.1%) patients were followed-up, 34 (53.1%) patients of which are currently alive with no signs of the relapse of the disease. Effectiveness of intraperitoneal chemotherapy was evaluated. Repeated local recurrence occurred in 5 (14.3%) of the 35 followed-up patients who underwent intraperitoneal chemotherapy, and in 6 (20.7%) of the 29 followed-up patients who received surgery alone (p = 0.2). Distant metastases were found in 9 (25.7%) and in 5 patients (17.2%) patients, respectively (p = 0.17), and peritoneal carcinomatosis in 1 (2.9%) and 4 (13.8%) cases, respectively (p = 0.09). Disease-free 5-year survival rate in patients who received intraperitoneal chemotherapy was 57.1%, and in patients received only surgical treatment - 48.3% (p = 0.15).

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