“Silent” ACTH-secreting carcinoma of hypophysis with extraand intracranial metastases: case report and literature review
https://doi.org/10.18027/2224-5057-2017-3-81-88
Abstract
The article presents a clinical case of “silent” ACTH-secreting pituitary carcinoma with multiple extra- and intracranial metastases. The patient received combined treatment including transsphenoidal removal of the tumor, 18 courses of palliative chemotherapy, 3 courses of stereotactic irradiation for primary tumor, therapy with cabergoline and somatostatin analogues. The patient lived 2 years and 9 months after the primary diagnosis of the tumor was made. There was a decrease in size of the primary tumor after radiotherapy, and chemotherapy resulted in a decrease in the metabolic activity of metastases which increased the life expectancy of the patient.
About the Authors
L. I. Astafyeva
FSBI N.N. Burdenko National Scientific and Practical Center for Neurosurgery
Russian Federation
MD, PhD
Russian Federation
MD, PhD
P. L. Kalinin
FSBI N.N. Burdenko National Scientific and Practical Center for Neurosurgery
Russian Federation
MD, PhD, Head of the 8-th Department of Oncology
Russian Federation
MD, PhD, Head of the 8-th Department of Oncology
N. I. Mikhaylov
FSBI N.N. Burdenko National Scientific and Practical Center for Neurosurgery
Russian Federation
MD
Russian Federation
MD
Y. Y. Trunin
FSBI N.N. Burdenko National Scientific and Practical Center for Neurosurgery
Russian Federation
PhD
Russian Federation
PhD
G. L. Kobyakov
FSBI N.N. Burdenko National Scientific and Practical Center for Neurosurgery
Russian Federation
MD, PhD
Russian Federation
MD, PhD
D. R. Naskhletashvili
FSBI N.N. Blokhin Russian Cancer Research Center
Russian Federation
PhD
Russian Federation
PhD
L. V. Shishkina
FSBI N.N. Burdenko National Scientific and Practical Center for Neurosurgery
Russian Federation
PhD
Competing Interests: к. м. н., ведущий научный сотрудник патоморфологического отделения
Russian Federation
PhD
Competing Interests: к. м. н., ведущий научный сотрудник патоморфологического отделения
O. F. Tropinskaya
FSBI N.N. Burdenko National Scientific and Practical Center for Neurosurgery
Russian Federation
PhD
Russian Federation
PhD
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For citations:
Astafyeva L.I., Kalinin P.L., Mikhaylov N.I., Trunin Y.Y., Kobyakov G.L., Naskhletashvili D.R., Shishkina L.V., Tropinskaya O.F. “Silent” ACTH-secreting carcinoma of hypophysis with extraand intracranial metastases: case report and literature review. Malignant tumours. 2017;(3):81-88. (In Russ.) https://doi.org/10.18027/2224-5057-2017-3-81-88
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