tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2017-3-81-88tumors-396Research ArticleОБЗОРЫ И АНАЛИТИКАREVIEWS AND ANALYSIS«Немая» АКТГ-секретирующая карцинома гипофиза с экстра- и интракраниальными метастазами (описание клинического случая и обзор литературы)“Silent” ACTH-secreting carcinoma of hypophysis with extraand intracranial metastases: case report and literature reviewАстафьеваЛ. И.AstafyevaL. I.

д. м. н., ведущий научный сотрудник 8 нейрохирургического отделения

MD, PhD

last@nsi.ruКалининП. Л.KalininP. L.

д. м. н., заведующий 8 нейрохирургическим отделением

MD, PhD, Head of the 8-th Department of Oncology

pkalinin@nsi.ruМихайловН. И.MikhaylovN. I.

аспирант 8 нейрохирургического отделения

MD

nmichailov@nsi.ruТрунинЮ. Ю.TruninY. Y.

к. м. н., старший научный сотрудник отделения радиологии и радиохирургии

PhD

ytrunin@nsi.ruКобяковГ. Л.KobyakovG. L.

д. м. н., ведущий научный сотрудник 7 нейрохирургического отделения

MD, PhD

gkobiakov@nsi.ruНасхлеташвилиД. Р.NaskhletashviliD. R.

к. м. н., старший научный сотрудник нейрохирургического (онкологического) отделения

PhD

nas-david@yandex.ruШишкинаЛ. В.ShishkinaL. V.

PhD

lshishkina@nsi.ruТропинскаяО. Ф.TropinskayaO. F.

к. м. н., врач нейроофтальмологической группы

PhD

otropinskaya@nsi.ruФГАУ «ННПЦН им. акад. Н. Н. Бурденко»РоссияFSBI N.N. Burdenko National Scientific and Practical Center for NeurosurgeryRussian FederationФГБУ «РОНЦ им. Н. Н. Блохина»РоссияFSBI N.N. Blokhin Russian Cancer Research CenterRussian Federation201717112017038188Copyright © Астафьева Л.И., Калинин П.Л., Михайлов Н.И., Трунин Ю.Ю., Кобяков Г.Л., Насхлеташвили Д.Р., Шишкина Л.В., Тропинская О.Ф., 20172017Астафьева Л.И., Калинин П.Л., Михайлов Н.И., Трунин Ю.Ю., Кобяков Г.Л., Насхлеташвили Д.Р., Шишкина Л.В., Тропинская О.Ф.Astafyeva L.I., Kalinin P.L., Mikhaylov N.I., Trunin Y.Y., Kobyakov G.L., Naskhletashvili D.R., Shishkina L.V., Tropinskaya O.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/396

В статье представлен клинический пример «немой» АКТГ-секретирующей карциномы гипофиза с множественными экстра- и интракраниальными метастазами. Пациенту было проведено комбинированное лечение, включающее транс-сфеноидальное удаление опухоли, 18 курсов паллиативной химиотерапии (ПХТ) и 3 курса стереотаксического облучения (СРТ) первичного образования, терапия каберголином и аналогами соматостатина. Больной прожил 2 года и 9 месяцев после обнаружения опухоли. На фоне лучевой терапии отмечалось уменьшение размеров первичной опухоли, а химиотерапия приводила к уменьшению метаболической активности метастазов.

 

 

 

 

The article presents a clinical case of “silent” ACTH-secreting pituitary carcinoma with multiple extra- and intracranial metastases. The patient received combined treatment including transsphenoidal removal of the tumor, 18 courses of palliative chemotherapy, 3 courses of stereotactic irradiation for primary tumor, therapy with cabergoline and somatostatin analogues. The patient lived 2 years and 9 months after the primary diagnosis of the tumor was made. There was a decrease in size of the primary tumor after radiotherapy, and chemotherapy resulted in a decrease in the metabolic activity of metastases which increased the life expectancy of the patient.

 

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The authors declare that there are no conflicts of interest present.