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Иммунорегуляторные функции ингибиторов PD-1/PD-L1 и развитие к ним резистентности

https://doi.org/10.18027/2224-5057-2017-2-94-99

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Аннотация

Данный обзор представляет современное понимание об ингибиторах PD-1/PD-L1. Несмотря на выраженный ответ на иммунотерапию ингибиторами чекпоинтов в ряде нозологий, в 60% случаев отмечается либо первичная, либо приобретенная резистентность. Механизмы, лежащие в основе резистентности, также освещены в данной статье. 

Об авторе

М. С. Саяпина
ФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» (РОНЦ им. Н. Н. Блохина), Москва
Россия
аспирант отделения клинической фармакологии и химиотерапии


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Для цитирования:


Саяпина М.С. Иммунорегуляторные функции ингибиторов PD-1/PD-L1 и развитие к ним резистентности. Злокачественные опухоли. 2017;(2):94-99. https://doi.org/10.18027/2224-5057-2017-2-94-99

For citation:


Sayapina M.S. Immunoregulatory functions of PD-1/PD-L1 inhibitors and development of resistance to them. Malignant tumours. 2017;(2):94-99. (In Russ.) https://doi.org/10.18027/2224-5057-2017-2-94-99

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