Sentinel lymph nodes in malignant tumors
https://doi.org/10.18027/2224-5057-2017-1-70-77
Abstract
The paper reflected the background of the concept, history of lymphography, as well as the current understanding the problem by studying of the concept of sentinel lymph nodes in malignant tumors. As metastasis to regional lymph nodes is the first step in the spread of most malignant tumors the status of the regional lymph node has diagnostic value for
determining the degree of malignancy. The combination of two imaging techniques of sentinel lymph node allows to identif y in almost cases, including in any tumor location even in uncer tain direction of lymph flow. In case of the negative sentinel lymph
node can be argued on the absence of metastases in other lymph nodes. Routine histological study of the lymph node should be completed by Immunohistochemistry analysis (Real-time PCR). Therapeutic lymph node dissection should be performed only by histological and Real-time PCR verification of tumor metastases in lymph nodes. In case of detection of micrometastases in lymph node remote question of the advantage of total lymph nodes dissection requires the fur ther discussion.
determining the degree of malignancy. The combination of two imaging techniques of sentinel lymph node allows to identif y in almost cases, including in any tumor location even in uncer tain direction of lymph flow. In case of the negative sentinel lymph
node can be argued on the absence of metastases in other lymph nodes. Routine histological study of the lymph node should be completed by Immunohistochemistry analysis (Real-time PCR). Therapeutic lymph node dissection should be performed only by histological and Real-time PCR verification of tumor metastases in lymph nodes. In case of detection of micrometastases in lymph node remote question of the advantage of total lymph nodes dissection requires the fur ther discussion.
About the Authors
A. V. ERMAKOV
MNIOI P. A. Herzen
Russian Federation
MD, PhD, researcher
Russian Federation
MD, PhD, researcher
E. K. SARIBEKYAN
MNIOI P. A. Herzen
Russian Federation
MD, PhD, DSc, leading researcher
Russian Federation
MD, PhD, DSc, leading researcher
N. V. ABLITSOVA
MNIOI P. A. Herzen
Russian Federation
MD, PhD, researcher
Russian Federation
MD, PhD, researcher
F. N. USOV
MNIOI P. A. Herzen
Russian Federation
MD, PhD, researcher
Russian Federation
MD, PhD, researcher
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Review
For citations:
ERMAKOV A.V., SARIBEKYAN E.K., ABLITSOVA N.V., USOV F.N. Sentinel lymph nodes in malignant tumors. Malignant tumours. 2017;(1):70-77. (In Russ.) https://doi.org/10.18027/2224-5057-2017-1-70-77
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