IMMUNE-MEDIATED ADVERSE EVENTS ASSOCIATED WITH IMMUNE CHECKPOINT INHIBITORS THERAPY
https://doi.org/10.18027/2224-5057-2016-4-68-76
Abstract
In recent years, immunotherapy is the main emphasis approach for malignant tumors treatment due to the development and registration of a new class of drugs –immune checkpoint inhibitors. Results of the randomized clinical trials, which showed a benefit in overall survival in comparison with standard therapy, was the basis for registration of this class of medicines [1–3]. Their toxicity profile is more favorable. However, the adverse reactions, which accrues during immunotherapy, are essentially new and different from standard chemotherapy. The standard management algorithm compensates the variety of immunemediated adverse reactions [4]. Early detection and timely treatment is necessary for the successful management of these adverse reactions.
About the Authors
E. V. Reutova
N. N. Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
Reutova Elena Valeryevna – MD, PhD, senior staff scientist, Moscow
K. P. Laktionov
N. N. Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
Laktionov Konstantin Pavlovich – MD, PhD, DSc, Professor, leading researcher, Moscow
V. V. Breder
N. N. Blokhin Russian Cancer Research Center
Russian Federation
Breder Valery Vladimirovich – MD, PhD, leading research scientist, Moscow
Russian Federation
Breder Valery Vladimirovich – MD, PhD, leading research scientist, Moscow
K. A. Sarantseva
N. N. Blokhin Russian Cancer Research Center
Russian Federation
Sarantseva Ksenia Andreevna – post-graduate student
Russian Federation
Sarantseva Ksenia Andreevna – post-graduate student
M. A. Okruzhnova
N. N. Blokhin Russian Cancer Research Center
Russian Federation
Okruzhnova Maria Aleksandrovna – associate scientist
Russian Federation
Okruzhnova Maria Aleksandrovna – associate scientist
M. V. Peregudova
N. N. Blokhin Russian Cancer Research Center
Russian Federation
Peregudova Marina Valeryevna – associate scientist
Russian Federation
Peregudova Marina Valeryevna – associate scientist
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Review
For citations:
Reutova E.V., Laktionov K.P., Breder V.V., Sarantseva K.A., Okruzhnova M.A., Peregudova M.V. IMMUNE-MEDIATED ADVERSE EVENTS ASSOCIATED WITH IMMUNE CHECKPOINT INHIBITORS THERAPY. Malignant tumours. 2016;(4):68-76. (In Russ.) https://doi.org/10.18027/2224-5057-2016-4-68-76
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