THE ROLE INTEGRINS IN INVASII AND METASTATIC SKIN OF MALIGNANT TUMORS
https://doi.org/10.18027/2224-5057-2016-1-5-9
Abstract
Malignant tumors of skin take the leading place in neoplastic incidence worldwide. Currently, concerning the development of molecular biology and genetics, it becomes clear that these tumors are heterogenic and have different biological characteristics that of prognostic and predictive significance. Various degree of integrin receptors expression, which can influence processes of an invasion and metastasis, belongs to such changes. We review the problem of modern understanding of the integrin’s influence on skin tumor progression and development of new approaches for antineoplastic therapy application.
About the Authors
K. S. Titov
Moscow Clinical Research Centr
Russian National Medical University
Russian Federation
Russian Federation
MD, RhD, DSc, head of the Оnсоsurgery Department tumors of skin and soft fabrics; assistant professor of the Department of Oncology and Radiation Therapy
D. L. Rotin
Moscow Clinical Research Centr
Russian Federation
MD, RhD, DSc, head of the Patomorphologic Department
Russian Federation
MD, RhD, DSc, head of the Patomorphologic Department
A. M. Kazakov
Russian National Medical University
Russian Federation
student
Russian Federation
student
E. A. Sherbakova
Moscow Clinical Research Centr
Russian Federation
doctor of the Geriatric Department
Russian Federation
doctor of the Geriatric Department
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Review
For citations:
Titov K.S., Rotin D.L., Kazakov A.M., Sherbakova E.A. THE ROLE INTEGRINS IN INVASII AND METASTATIC SKIN OF MALIGNANT TUMORS. Malignant tumours. 2016;(1):5-9. (In Russ.) https://doi.org/10.18027/2224-5057-2016-1-5-9
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