Genetic prerequisitions of post-chemoradiotherapy pulmonary damages development and ways of prevention in breast cancer patients
https://doi.org/10.18027/2224-5057-2015-1-3-8
Abstract
The article is devoted to the study of genetic background of postchemoradiation lung injuries in breast cancer patients. Genetic determinism of inflammatory mediators content, fibrogenesis and oxidative stress and their role in the pneumofibrosis development were proved. The influence of genes MTHFR and MMP-12 in the development post chemoradiation pneumofibrosis was proved. During the mutation T/T mutation at position 667 of the MTHFR gene pulmonary fibrosis post chemoradiotherapy pneumofibrosis develops in 100% of cases, in patients with C/C genotype — only in 9%. Prescription of quercetin and thiotriazoline reduces the incidence of post chemo-radiation bronchitis and pneumonitis in 27%, lung sclerosis and fibrosis in 30%.
References
1. Vasilenko E.A., Yarosh O.K. Pharmacokinetic profile of liposomal quercetin in brain tissue. Lekarstva [Medicaments]. 2006. no. 3–4, p.72–76.
2. Vorotyntseva N.S., Golyev S.S.Rentgenopulmonologiya [Radiopulmonology]. Moscow. MIA Publ., 2009. 280 p.
3. Stefanov A.V., Derimedved L.V., Churilova I.V. Clinicoexperimental justification of using of superoxidedismutase in medicine. NFaU «Zolotye Stranitsy» [NFaU «Golden pages”], 2004.— 288 p.
4. Kislova A.V., Sapatyj A.L., Kupnovitske I.G. et al. Correction of endothelial dysfunction caused by gamma-radiation using liposomal qurcetin. Fiziologicheskyj Zhurnal [Physiological Journal]. 2006. no. 3 p.78–81.
5. Kuznetsova S., Kuznetsov V., Vorobey M. Influence of tiotriazolyne and pyracetam combination on functional state of central nervous system in patients after ischemic stroke. Diagnostika i lecheniye [Diagnostics and treatment]. 2005. no. 2, p.73–77.
6. Pentyuk N.A. Metabolic predictors of liver fibrosis in patients with chronic hepatitis. Experimentalnaya I klinicheskaya meditsina [Experimental and clinical medicine]. 2011. no.3–4, p.72–76.
7. Aghamohammadi V. Effect of folic acid supplementation on homocysteine, serum total antioxidant capacity, and malondialdehyde in patients with type 2 diabetes mellitus / V. Aghamohammadi, B. Gargari, A. Aliasgharzadeh // J Am Coll Nutr.— 2011.— V. 304 (3).— Р. 210–215.
8. Chemotherapy-related delayed bilateral spontaneous pneumothorax and lung fibrosis: methotrexate or cyclophosphamide, or both? / L. Fang, C. Huang, A. Chuang [et al.] // Clin Respir J.— 2010.— Vol. 4, № 4.— P. 254–255.
9. Diesel exhaust particles induce matrix metalloprotease-1 in human lung epithelial cells via a NADP (H) oxidase/NOX4 redox-dependent mechanism / N. Amara, R. Bachoual R, M. Desmard [et al.] // Am J Physiol Lung Cell Mol Physiol.— 2007.— Vol. 293, № 1.— P. 170–181.
10. Direct anti-cancer effect of oncostatin M on chondrosarcoma / E. David, P. Guihard, B. Brounais et al. // Int J Cancer.— 2011.— V. 128 (8).— Р. 1822–1835.
11. Myocardial fibrosis and TGFB expression in hyperhomocysteinemic rats / L. Raaf, C. Nol, M. Cherifi [et al.] // Mol Cell Biochem.— 2011.— V. 3447 (1–2).— Р. 63–70.
Review
For citations:
Hourani I.F. Genetic prerequisitions of post-chemoradiotherapy pulmonary damages development and ways of prevention in breast cancer patients. Malignant tumours. 2015;(1):3-8. (In Russ.) https://doi.org/10.18027/2224-5057-2015-1-3-8
Views:
1033
Email this article 