Treatment of patients with R AS-mutated colorectal cancer with lung metastases
https://doi.org/10.18027/2224-5057-2026-068
Abstract
Objective: to present and analyze the clinical treatment outcomes of patients with RAS-mutated metastatic colorectal cancer based on two case reports, assessing the efficacy of systemic therapy regimens, and demonstrating factors influencing treatment strategy and tumor response. These cases demonstrate the need for new markers and a personalized approach to therapy in patients with colorectal cancer. These observations were compared with current literature data, demonstrating the practical value of an individualized approach to treating patients with RAS-mutated metastatic colorectal cancer.
About the Authors
K. I. MurzakhanovaRussian Federation
Karina Ilgizovna Murzakhanova
23 Kashirskoe Shosse, Moscow 115478
Build. 1, 2 / 1 Barrikadnaya St., Moscow 125993
Competing Interests:
Tryakin A. A. has been a member of the editorial board of the journal Malignant Tumors since 2019, but had no role in the decision to publish this article. The article has undergone the journal’s peer-review process. The authors declared no other conflicts of interest.
O. A. Kuznetsova
Russian Federation
Olesya Alekseevna Kuznetsova
23 Kashirskoe Shosse, Moscow 115478
Competing Interests:
Tryakin A. A. has been a member of the editorial board of the journal Malignant Tumors since 2019, but had no role in the decision to publish this article. The article has undergone the journal’s peer-review process. The authors declared no other conflicts of interest.
G. G. Makiev
Russian Federation
Georgy Georgievich Makiev
23 Kashirskoe Shosse, Moscow 115478
Competing Interests:
Tryakin A. A. has been a member of the editorial board of the journal Malignant Tumors since 2019, but had no role in the decision to publish this article. The article has undergone the journal’s peer-review process. The authors declared no other conflicts of interest.
D. O. Lipatov
Russian Federation
Danila Olegovich Lipatov
23 Kashirskoe Shosse, Moscow 115478
Competing Interests:
Tryakin A. A. has been a member of the editorial board of the journal Malignant Tumors since 2019, but had no role in the decision to publish this article. The article has undergone the journal’s peer-review process. The authors declared no other conflicts of interest.
Yu. V. Eroshin
Russian Federation
Yuri Vladimirovich Eroshin
23 Kashirskoe Shosse, Moscow 115478
Competing Interests:
Tryakin A. A. has been a member of the editorial board of the journal Malignant Tumors since 2019, but had no role in the decision to publish this article. The article has undergone the journal’s peer-review process. The authors declared no other conflicts of interest.
D. H. Khudoerov
Russian Federation
23 Kashirskoe Shosse, Moscow 115478
Competing Interests:
Трякин А. А. является членом редакционного совета журнала Злокачественные опухоли с 2019 г., но не имеют никакого отношения к решению опубликовать эту статью. Статья прошла принятую в журнале процедуру рецензирования. Об иных конфликтах интересов авторы не заявляли.
A. A. Tryakin
Russian Federation
Alexey Alexandrovich Tryakin
23 Kashirskoe Shosse, Moscow 115478
Competing Interests:
Tryakin A. A. has been a member of the editorial board of the journal Malignant Tumors since 2019, but had no role in the decision to publish this article. The article has undergone the journal’s peer-review process. The authors declared no other conflicts of interest.
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Review
For citations:
Murzakhanova K.I., Kuznetsova O.A., Makiev G.G., Lipatov D.O., Eroshin Yu.V., Khudoerov D.H., Tryakin A.A. Treatment of patients with R AS-mutated colorectal cancer with lung metastases. Malignant tumours. 2026;16(1):108–117. (In Russ.) https://doi.org/10.18027/2224-5057-2026-068
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