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Treatment of patients with R AS-mutated colorectal cancer with lung metastases

https://doi.org/10.18027/2224-5057-2026-068

Abstract

Objective: to present and analyze the clinical treatment outcomes of patients with RAS-mutated metastatic colorectal cancer based on two case reports, assessing the efficacy of systemic therapy regimens, and demonstrating factors influencing treatment strategy and tumor response. These cases demonstrate the need for new markers and a personalized approach to therapy in patients with colorectal cancer. These observations were compared with current literature data, demonstrating the practical value of an individualized approach to treating patients with RAS-mutated metastatic colorectal cancer.

About the Authors

K. I. Murzakhanova
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia
Russian Federation

Karina Ilgizovna Murzakhanova

23 Kashirskoe Shosse, Moscow 115478

Build. 1, 2 / 1 Barrikadnaya St., Moscow 125993


Competing Interests:

Tryakin A. A. has been a member of the editorial board of the journal Malignant Tumors since 2019, but had no role in the decision to publish this article. The article has undergone the journal’s peer-review process. The authors declared no other conflicts of interest.



O. A. Kuznetsova
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

Olesya Alekseevna Kuznetsova

23 Kashirskoe Shosse, Moscow 115478


Competing Interests:

Tryakin A. A. has been a member of the editorial board of the journal Malignant Tumors since 2019, but had no role in the decision to publish this article. The article has undergone the journal’s peer-review process. The authors declared no other conflicts of interest.



G. G. Makiev
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

Georgy Georgievich Makiev

23 Kashirskoe Shosse, Moscow 115478


Competing Interests:

Tryakin A. A. has been a member of the editorial board of the journal Malignant Tumors since 2019, but had no role in the decision to publish this article. The article has undergone the journal’s peer-review process. The authors declared no other conflicts of interest.



D. O. Lipatov
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

Danila Olegovich Lipatov

23 Kashirskoe Shosse, Moscow 115478


Competing Interests:

Tryakin A. A. has been a member of the editorial board of the journal Malignant Tumors since 2019, but had no role in the decision to publish this article. The article has undergone the journal’s peer-review process. The authors declared no other conflicts of interest.



Yu. V. Eroshin
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

Yuri Vladimirovich Eroshin

23 Kashirskoe Shosse, Moscow 115478


Competing Interests:

Tryakin A. A. has been a member of the editorial board of the journal Malignant Tumors since 2019, but had no role in the decision to publish this article. The article has undergone the journal’s peer-review process. The authors declared no other conflicts of interest.



D. H. Khudoerov
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

23 Kashirskoe Shosse, Moscow 115478


Competing Interests:

Трякин А. А. является членом редакционного совета журнала Злокачественные опухоли с 2019 г., но не имеют никакого отношения к решению опубликовать эту статью. Статья прошла принятую в журнале процедуру рецензирования. Об иных конфликтах интересов авторы не заявляли.



A. A. Tryakin
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

Alexey Alexandrovich Tryakin

23 Kashirskoe Shosse, Moscow 115478


Competing Interests:

Tryakin A. A. has been a member of the editorial board of the journal Malignant Tumors since 2019, but had no role in the decision to publish this article. The article has undergone the journal’s peer-review process. The authors declared no other conflicts of interest.



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For citations:


Murzakhanova K.I., Kuznetsova O.A., Makiev G.G., Lipatov D.O., Eroshin Yu.V., Khudoerov D.H., Tryakin A.A. Treatment of patients with R AS-mutated colorectal cancer with lung metastases. Malignant tumours. 2026;16(1):108–117. (In Russ.) https://doi.org/10.18027/2224-5057-2026-068

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ISSN 2224-5057 (Print)
ISSN 2587-6813 (Online)