What is hidden from the view. The problem of chronic and delayed toxicity after immunotherapy based on clinical cases and literature review
https://doi.org/10.18027/2224-5057-2024-023
Abstract
The emergence of immunotherapy has revolutionized the treatment approaches of numerous malignancies. Patients that previously faced a prognosis of only a few months left to live can now enjoy extended lifespans for several years. Nevertheless, it is crucial to acknowledge that immunotherapy carries its own spectrum of adverse events. Notably, the issue of immune-related toxicity is progressively gaining prominence with each passing year. A distinctive feature of these immune-related adverse events is their propensity to transition into chronic conditions, with some manifesting long after discontinuation of immunotherapy. Given the current incorporation of adjuvant immunotherapy regimens in clinical guidelines, it becomes imperative to direct heightened attention towards the challenges associated with chronic and delayed toxicity of immunotherapy.
Keywords
immunotherapy,
toxicity,
oncology,
adverse events,
quality of life,
adrenal insufficiency,
thyreoiditis
Supporting agencies: The article was prepared without sponsorship
About the Authors
M. M. Sobolev
Oncology Center No. 1 of the City Clinical Hospital named after S.S. Yudin of the Moscow Department of Health
Russian Federation
Competing Interests:
Russian Federation
Maksim Mikhailovich Sobolev
18A Zagorodnoe Shosse, Moscow 117152
Competing Interests:
The authors declare that there are no possible conflicts of interest
I. A. Pokataev
Oncology Center No. 1 of the City Clinical Hospital named after S.S. Yudin of the Moscow Department of Health
Russian Federation
Competing Interests:
Russian Federation
Ilya Anatolevich Pokataev
18A Zagorodnoe Shosse, Moscow 117152
Competing Interests:
The authors declare that there are no possible conflicts of interest
E. S. Kuzmina
Oncology Center No. 1 of the City Clinical Hospital named after S.S. Yudin of the Moscow Department of Health
Russian Federation
Competing Interests:
Russian Federation
Evgeniya Sergeevna Kuzmina
18A Zagorodnoe Shosse, Moscow 117152
Competing Interests:
The authors declare that there are no possible conflicts of interest
V. N. Galkin
Oncology Center No. 1 of the City Clinical Hospital named after S.S. Yudin of the Moscow Department of Health
Russian Federation
Competing Interests:
Russian Federation
Vsevolod Nikolaevich Galkin
18A Zagorodnoe Shosse, Moscow 117152
Competing Interests:
The authors declare that there are no possible conflicts of interest
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For citations:
Sobolev M.M., Pokataev I.A., Kuzmina E.S., Galkin V.N. What is hidden from the view. The problem of chronic and delayed toxicity after immunotherapy based on clinical cases and literature review. Malignant tumours. 2024;14(3):86-91. (In Russ.) https://doi.org/10.18027/2224-5057-2024-023
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