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Злокачественные опухоли

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Редкие злокачественные опухоли вульвы: клиника, диагностика, подходы к лечению

https://doi.org/10.18027/2224-5057-2023-13-3s1-32-39

Аннотация

   Рак вульвы (РВ) является редким злокачественным новообразованием среди женщин, доля которого не превышает 4 % от всех онкологических заболеваний. Случаи же меланомы, саркомы, герминогенных и себацейцных гистологических подтипов РВ встречается крайне редко. Мы обобщили свой опыт и других авторов о клинике, диагностике и подходе
к лечению редких злокачественных новообразованиях РВ.

Об авторах

В. В. Саевец
ГАУЗ «Челябинский областной клинический центр онкологии и ядерной медицины»; ФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава России
Россия

Челябинск



Д. М. Ростовцев
ГАУЗ «Челябинский областной клинический центр онкологии и ядерной медицины»
Россия

Челябинск



А. А. Мухин
ГАУЗ «Челябинский областной клинический центр онкологии и ядерной медицины»
Россия

Челябинск



А. Ю. Шаманова
ГАУЗ «Челябинский областной клинический центр онкологии и ядерной медицины»; ФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава России
Россия

Челябинск



Н. К. Кузьмин
ФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава России
Россия

Челябинск



А. В. Таратонов
ГАУЗ «Челябинский областной клинический центр онкологии и ядерной медицины»
Россия

Челябинск



Л. В. Ярина
ГАУЗ «Челябинский областной клинический центр онкологии и ядерной медицины»; ФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава России
Россия

Челябинск



Список литературы

1. Bethesda M. SEER Cancer Statistics Factsheets : Vulvar Cancer // Tamil Nadu : NIH . – 2021.

2. Злокачественные новообразования в России в 2021 году (заболеваемость и смертность). Под ред. А.Д. Каприна, В.В. Старинского, Г.В. Петровой. М., 2022.

3. Oonk M. H. M. et al. European Society of Gynaecological Oncology Guidelines for the Management of Patients with Vulvar Cancer-Update 2023 // International Journal of Gynecologic Cancer. – 2023. – V. 33. – №. 7.

4. Vulvar Cancer, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology https://www.nccn.org/professionals/physician_gls/pdf/vulvar.pdf.

5. Sugiyama V. E. et al. Vulvar melanoma : a multivariable analysis of 644 patients // Obstetrics & Gynecology. – 2007. – V. 110. – №. 2. Part 1. – P. 296–301.

6. Moxley K. M. et al. Malignant melanoma of the vulva : an extension of cutaneous melanoma? // Gynecologic oncology. – 2011. – V. 122 . – №. 3 . – P. 612–617.

7. Mehra T. et al. Primary localization and tumor thickness as prognostic factors of survival in patients with mucosal melanoma // PLoS One. – 2014 . – V. 9 . – №. 11 . – P. e112535.

8. Leitao M. M. et al. Gynecologic Cancer InterGroup (GCIG) consensus review for vulvovaginal melanomas // International Journal of Gynecologic Cancer. – 2014 . – V. 24. – №. Supp 3.

9. Hassanein A. M. et al. Malignant melanoma associated with lichen sclerosus in the vulva of a 10-year-old // Pediatric dermatology. – 2004. – V. 21. – №. 4. – P. 473–476.

10. ACS. American Cancer Society—Key Statistic for Melanoma Skin Cancer. Available online: https://www.cancer.org/cancer/melanoma-skin-cancer/about/key-statistics (accessed on 21 May 2022).

11. Kibbi N., Kluger H., Choi J. N. Melanoma : clinical presentations // Melanoma. – 2016 . – P. 107–129.

12. Swetter S. M. et al. NCCN Guidelines® insights : melanoma : cutaneous, version 2.2021 : featured updates to the NCCN guidelines // Journal of the National Comprehensive Cancer Network . – 2021. – V. 19 . – №. 4. – P. 364–376.

13. Stang A. et al. Population-based incidence rates of malignant melanoma of the vulva in Germany // Gynecologic oncology. – 2005 . – V. 96. – №. 1 . – P. 216–221.

14. You J. S., Jones P. A. Cancer genetics and epigenetics : two sides of the same coin? // Cancer cell. – 2012. – V. 22. – №. 1. – P. 9–20.

15. Dobrică E. C. et al. Vulvar and vaginal melanomas—the darker shades of gynecological cancers // Biomedicines. – 2021 . – V. 9 . – №. 7.– P. 758.

16. Heinzelmann-Schwarz V. A. et al. A clinicopathological review of 33 patients with vulvar melanoma identifies c-KIT as a prognostic marker // International journal of molecular medicine. – 2014. – V. 33. – №. 4. – P. 784–794.

17. Paolino G. et al. Vitamin D receptor immunohistochemistry variability in sun-exposed and non-sun-exposed melanomas // Melanoma Research . – 2017. – V. 27. – №. 1. – P. 17–23.

18. Tseng D. et al. Oncogenic mutations in melanomas and benign melanocytic nevi of the female genital tract // Journal of the American Academy of Dermatology. – 2014. – V. 71 . – №. 2 . – P. 229–236.

19. Jiveskog S. et al. N-ras mutations are common in melanomas from sun-exposed skin of humans but rare in mucosal membranes or unexposed skin // Journal of investigative dermatology. – 1998. – V. 111 . – №. 5. – P. 757–761.

20. Torres-Cabala C. A. et al. Correlation between KIT expression and KIT mutation in melanoma : a study of 173 cases with emphasis on the acral-lentiginous / mucosal type // Modern pathology. – 2009. – V. 22. – №. 11 .– P. 1446–1456.

21. Omholt K. et al. KIT pathway alterations in mucosal melanomas of the vulva and other sites // Clinical cancer research. – 2011. – V. 17. – №. 12 . – P. 3933–3942.

22. Schoenewolf N. L. et al. Sinonasal, genital and acrolentiginous melanomas show distinct characteristics of KIT expression and mutations // European journal of cancer. – 2012. – V. 48 .– №. 12. – P. 1842–1852.

23. Hou J. Y. et al. Vulvar and vaginal melanoma : a unique subclass of mucosal melanoma based on a comprehensive molecular analysis of 51 cases compared with 2253 cases of nongynecologic melanoma // Cancer. – 2017. – V. 123 . – №. 8 . – P. 1333–1344.

24. Wylomanski S. et al. BRAF mutations might be more common than supposed in vulvar melanomas // Experimental dermatology. – 2018 . – V. 27. – №. 2 . – P. 210–213.

25. Saleh B. et al. Frequent PD-L1 expression in malignant melanomas of the vulva // International Journal of Gynecological Pathology. – 2018 .– V. 37. – №. 5 . – P. 477–481.

26. Randic T. et al. NRAS mutant melanoma : Towards better therapies // Cancer treatment reviews. – 2021. V. 99. – P. 102238.

27. Tseng D. et al. Oncogenic mutations in melanomas and benign melanocytic nevi of the female genital tract // Journal of the American Academy of Dermatology. – 2014 . – V. 71. – №. 2. – P. 229–236.

28. Grill C., Larue L. NRAS, NRAS, which mutation is fairest of them all? // Journal of Investigative Dermatology. – 2016. – V. 136. – №. 10. – P. 1936–1938.

29. Ragnarsson-Olding B. K. Primary malignant melanoma of the vulva an aggressive tumor for modeling the genesis of non-UV light-associated melanomas // Acta Oncologica. – 2004. – V. 43. – №. 5. – P. 421–435.

30. Murzaku E. C. et al. Vulvar nevi, melanosis, and melanoma : an epidemiologic, clinical, and histopathologic review // Journal of the American Academy of Dermatology. – 2014. – V. 71. – №. 6. – P. 1241–1249.

31. Wohlmuth C., Wohlmuth-Wieser I. Vulvar melanoma : molecular characteristics, diagnosis, surgical management, and medical treatment // American Journal of Clinical Dermatology. – 2021 . – V. 22 .– №. 5 . – P. 639–651.

32. An J. et al. Primary malignant amelanotic melanoma of the female genital tract : report of two cases and review of literature // Melanoma research. – 2009. – V. 19 . – №. 4. – P. 267–270.

33. Baderca F. et al. Amelanotic vulvar melanoma : case report and review of the literature // Rom J Morphol Embryol.– 2008. – P. 49. – №. 2. – P. 219–228.

34. Ragnarsson-Olding B. K. et al. Malignant melanoma of the vulva in a nationwide, 25-year study of 219 Swedish females : clinical observations and histopathologic features // Cancer : Interdisciplinary International Journal of the American Cancer Society. – 1999. – V. 86. – №. 7. – P. 1273–1284.

35. Brenn T. Atypical genital nevus // Archives of Pathology & Laboratory Medicine. – 2011 . – V. 135. – №. 3. – P. 317–320.

36. Ditto A. et al. Surgical management and prognostic factors of vulvovaginal melanoma // Journal of lower genital tract disease. – 2016. – V. 20. – №. 3 . – P. e24-e29.

37. Lotem M. et al. Mucosal melanoma of the female genital tract is a multifocal disorder // Gynecologic oncology . – 2003 .– V. 88. – №. 1. – P. 45–50.

38. Vitale S. G. et al. Recent trends in surgical and reconstructive management of vulvar cancer : review of literature // Updates in surgery. – 2015. – V. 67. – V. 367–371.

39. Gaarenstroom K. N. et al. Postoperative complications after vulvectomy and inguinofemoral lymphadenectomy using separate groin incisions // International Journal of Gynecologic Cancer. – 2003. – V. 13 . – №. 4.

40. Gadducci A. et al. Melanoma of the lower genital tract : Prognostic factors and treatment modalities // Gynecologic Oncology. – 2018 . – V. 150. – №. 1. – P. 180–189.

41. Boer F. L. et al. Vulvar malignant melanoma : Pathogenesis, clinical behaviour and management : Review of the literature // Cancer Treatment Reviews. – 2019 . – V. 73 . – P. 91–103.

42. Smith H. G. et al. Ano-uro-genital mucosal melanoma UK national guidelines // European Journal of Cancer. – 2020 . – V. 135 . – P. 22–30.

43. Iacoponi S. et al. Prognostic factors of recurrence and survival in vulvar melanoma : subgroup analysis of the VULvar CANcer study // International Journal of Gynecologic Cancer. – 2016. – V. 26. – №. 7.

44. Nagarajan P. et al. Tumor thickness and mitotic rate robustly predict melanoma-specific survival in patients with primary vulvar melanoma : a retrospective review of 100 cases // Clinical Cancer Research. – 2017 . – V. 23. – №. 8 . – P. 2093–2104.

45. Sanchez A. et al. Primary genitourinary melanoma : epidemiology and disease-specific survival in a large population-based cohort // Urologic Oncology : Seminars and Original Investigations. – Elsevier, 2016. – V. 34 .– №. 4 . – P. 166. e7–166. e14.

46. Scheistrøen M. et al. Malignant melanoma of the vulva. Evaluation of prognostic factors with emphasis on DNA ploidy in 75 patients // Cancer. – 1995 . – V. 75 . – №. 1. – P. 72–80.

47. Raspagliesi F. et al. Prognostic indicators in melanoma of the vulva // Annals of surgical oncology . – 2000. – V. 7 . – P. 738–742.

48. Irvin Jr W. P. et al. Vulvar melanoma : a retrospective analysis and literature review // Gynecologic Oncology. – 2001. – V. 83 .– №. 3 . – P. 457–465.

49. Chokoeva A. A. et al. Vulvar sarcomas : short guideline for histopathological recognition and clinical management. Part 2 // International Journal of Immunopathology and Pharmacology. – 2015 .– V. 28. – №. 2. – P. 178–186.

50. Chokoeva A. A. et al. Vulvar sarcomas : short guideline for histopathological recognition and clinical management. Part 1 // International journal of immunopathology and pharmacology. – 2015 .– V. 28 . – №. 2 . – P. 168–177.

51. Nucci M. R., Fletcher C. D. M. Liposarcoma (Atypical Lipomatous Tumors) of the Vulva A Clinicopathologic Study of Six Cases // International journal of gynecological pathology. – 1998 . – V. 17 .– №. 1 .– P. 17–23.

52. Magné N. et al. Sarcoma of vulva, vagina and ovary // Best Practice & Research Clinical Obstetrics & Gynaecology. – 2011 . – V. 25 . – №. 6 .– P. 797–801.

53. Johnson S. et al. Vulvar sarcoma outcomes by histologic subtype : a Surveillance, Epidemiology, and End Results (SEER) database review // International Journal of Gynecologic Cancer. – 2020 . – V. 30 .– №. 8.

54. Nogales F. F., Preda O., Nicolae A. Yolk sac tumours revisited. A review of their many faces and names // Histopathology. – 2012. – Т. 60. – №. 7. – P. 1023–1033.

55. JK M. C. K. Heerema-M cKenney A, Rouse RV. Extragonadal germ cell tumors : A review with emphasis on pathologic features, clinical prognostic variables, and differential diagnostic considerations // Adv Anat Pathol. – 2007. – V. 14. – №. 2. – P. 69–92.

56. Clement P. B., Young R. H., Scully R. E. Extraovarian pelvic yolk sac tumors // Cancer . – 1988 .– V. 62 .– №. 3 . – P. 620–626.

57. Dede M. et al. Extragonadal yolk sac tumor in pelvic localization. A case report and literature review // Gynecologic oncology . – 2004. – V. 92 .– №. 3. – P. 989–991.

58. Xu W. et al. Vulvar yolk sac tumor diagnosed during pregnancy, with recurrence during subsequent second pregnancy // Gynecologic Oncology Reports. – 2015. – V. 12. – P. 67.

59. Euscher E. D. Unusual presentations of gynecologic tumors : extragonadal yolk sac tumor of the vulva // Archives of pathology & laboratory medicine. – 2017. – V. 141. – №. 2. – P. 293–297.

60. Ламоткин И.А. Онкодерматология. [Электронный ресурс] : атлас : учебное пособие . – Эл. изд .– М. : Лаборатория знаний, 2021. Режим доступа: http://client.studmedlib.ru/book/ISBN9785932085561.html.

61. Rulon D. B., Helwig E. B. Cutaneous sebaceous neoplasms // Cancer. – 1974 .– V. 33. – №. 1. – P. 82–102.

62. Pusiol T., Morichetti D., Zorzi M. G. Sebaceous carcinoma of the vulva : critical approach to grading and review of the literature // Pathologica. – 2011. – V. 103 .– №. 3. – P. 64–67.

63. Carlson J. W. et al. Sebaceous carcinoma of the vulva : a case report and review of the literature // Gynecologic oncology. – 1996 . – V. 60. – №. 3. – P. 489–491.

64. Thakur B. K. et al. Multifocal sebaceous carcinoma of the vulva // Indian Journal of Dermatology, Venereology and Leprology. – 2017. – V. 83 . – P. 221.

65. Sullivan S. A. et al. Sebaceous carcinoma of the vulva : A case report and review of the literature // Gynecologic Oncology Reports. – 2016. – V. 18. – P. 40.

66. Yam P. et al. M363 SEBACEOUS CARCINOMA OF THE VULVA A RARE TUMOR OF VULVA // International Journal of Gynaecology and Obstetrics. – 2012. – V. 119 . – №. 3 . – P. 6.

67. Escalonilla P. et al. Sebaceous carcinoma of the vulva // The American journal of dermatopathology. – 1999. – V. 21. – №. 5 .– P. 468.

68. Kawamoto M. et al. Sebaceous carcinoma of the vulva // Pathology international. – 1995 .– V. 45 . – №. 10. – P. 767–773.

69. Jacobs D. M., Sandles L. G., Leboit P. E. Sebaceous carcinoma arising from Bowen’s disease of the vulva // Archives of dermatology .– 1986 .– V. 122. – №. 10. – P. 1191–1193.

70. Ikuse S. A case of sebaceous carcinoma // Jpn. J. Dermatol . – 1976 . – V. 86 .– P. 783.

71. Alharthi H. et al. Sebaceous carcinoma of the vulva : a case report and review of the literature // Avicenna Journal of Medicine .– 2021. – V. 11. – №. 01. – P. 49–53.

72. Yamamoto A. et al. Sebaceous carcinoma of the vulva treated with sentinel lymph node biopsy : a case report and literature review // International Cancer Conference Journal .– Singapore : Springer Singapore, 2021. – V. 10. – №. 3. – P. 239–243.

73. Khan Z. et al. Sebaceous carcinoma of the vulva // BJOG (Oxford. Print). – 2003. – Т. 110. – №. 2. – С. 227–228.


Рецензия

Для цитирования:


Саевец В.В., Ростовцев Д.М., Мухин А.А., Шаманова А.Ю., Кузьмин Н.К., Таратонов А.В., Ярина Л.В. Редкие злокачественные опухоли вульвы: клиника, диагностика, подходы к лечению. Злокачественные опухоли. 2023;13(3s1):32-39. https://doi.org/10.18027/2224-5057-2023-13-3s1-32-39

For citation:


Саевец В.В., Ростовцев Д.М., Мухин А.А., Шаманова А.Ю., Кузьмин Н.К., Таратонов А.В., Ярина Л.В. Редкие злокачественные опухоли вульвы: клиника, диагностика, подходы к лечению. Malignant tumours. 2023;13(3s1):32-39. (In Russ.) https://doi.org/10.18027/2224-5057-2023-13-3s1-32-39

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ISSN 2224-5057 (Print)
ISSN 2587-6813 (Online)