The impact of time of performance of delayed orchiectomy on survival of patients with advanced germ cell tumors of testicles
https://doi.org/10.18027/2224-5057-2014-2-3-10
Abstract
Aim: To investigate the impact of time of performance of delayed orchiectomy on overall survival of patients with advanced germ cell tumors of testicle who didn’t undergo surgery before starting of treatment.
Materials and methods: From 1986 to 2010 in the department of clinical pharmacology and chemotherapy 71 (4,8%) of 1486 patients underwent delayed orchiectomy. During the first course of chemotherapy (1st group) 39 (55%) patients underwent surgery, 21 (29,6%) patients - during 2nd -4th courses (2nd group), after the ending of chemotherapy – 11 (15,5%) patients (3rd group).
Results: Final histological investigation of the specimens revealed viable germ cell tumor in 25 (64,1%) patients in the 1st group, in 10 (47,7%) patients in the 2nd group and no viable tumor in the 3rd group.
Conclusion: Performance of orchiectomy simultaneously with the removal of the other sites of the tumor after chemotherapy doesn’t impair survival.
About the Authors
M. Yu. Fedyanin
Российский онкологический научный центр им. Н. Н. Блохина
Russian Federation
Russian Federation
A. A. Tryakin
Российский онкологический научный центр им. Н. Н. Блохина
Russian Federation
Russian Federation
A. A. Bulanov
Российский онкологический научный центр им. Н. Н. Блохина
Russian Federation
Russian Federation
I. A. Fainshtein
Российский онкологический научный центр им. Н. Н. Блохина
Russian Federation
Russian Federation
Yu. S. Sergeev
Российский онкологический научный центр им. Н. Н. Блохина
Russian Federation
Russian Federation
V. B. Matveev
Российский онкологический научный центр им. Н. Н. Блохина
Russian Federation
Russian Federation
A. M. Garin
Российский онкологический научный центр им. Н. Н. Блохина
Russian Federation
Russian Federation
S. A. Tyulyandin
Российский онкологический научный центр им. Н. Н. Блохина
Russian Federation
Russian Federation
References
1. Krege S, Beyer J, Souchon R, Albers P, Albrecht W, Algaba F, et al.: European consensus conference on diagnosis and treatment of germ cell cancer: a report of second meeting of the European Germ Cell Cancer Concensus Group (EGCCCG): part II // European urology. 2008;53:497–513.
2. Ploen L, Setchell BP. Blood-testis barriers revisited. A homage to Lennart Nicander // Int J Androl. 1991;15:1–4.
3. Okumura K, Lee IP and Dixon RL. Permeability of selected drugs and chemicals across the blood-testis harrier of the rat // J. Phannacol. Exp. Ther. 1975 Jul;194 (1):89–95.
4. Cordon-Cardo C, O’Brien JP, Casals D, Rittman GL, Biedler JL, Melamed MR, et al.: Multidrugresistance gene (P-glycoprotein) is expressed by endothelial cells at blood -brain barrier sites // Proc. Natl. Acad. Sci. 1989; 86: 695–698.
5. International Germ Cell Collaborative Group. International Germ Cell Consensus Classification: A prognostic Factor-Based Staging System for Metastatic Germ Cell Cancers // J. of Clinical Oncology. 1997 Feb; Vol.15 (2):594–603.
6. Leibovich I, Little JS, Forester RS, Rowland RG, Bihrle R, Donohue JP. Delayed orchiectomy after chemotherapy for metastatic nonseminomatous germ cell tumors // The journal of urology. 1996 Mar;155:952–954.
7. Snow BW, Rowland RG, Donohue JP, Einhorn LH, Williams SD. Review of delayed orchiectomy in patients with disseminated testis tumors // J Urol. 1983 Mar;129 (3):522–3.
8. Greist A, Einhorn LH, Williams SD, Donohue JP, Rowland RG. Pathologic findings at orchiectomy following chemotherapy for disseminated testicular cancer // J Clin Oncol. 1984 Sep;2 (9):1025–7.
9. Chong C, Logothetis CJ, von Eschenbach A, Ayala A, Samuels M. Orchiectomy in advanced germ cell cancer following intensive chemotherapy: a comparison of systemic to testicular response // J Urol. 1986 Dec;136 (6):1221–3.
10. Ondrus, D, Horfiak M and Matoska J. Neo-adjuvant chemotherapy with delayed orchiectomy in patients with advanced germ cell testicular cancer // Neoplasma. 1993;40 (3):189–92.
11. Simmonds PD, Mead GM, Lee AH, Theaker JM, Dewbury K, Smart CJ. Orchiectomy after chemotherapy in patients with metastatic testicular cancer. Is it indicated? // Cancer. 1995 Feb 15;75 (4):1018–24.
12. Ondrus D, Horn k M, Breza J, Mat’oska J, Schnorrer M, Belan V, et al.: Delayed orchiectomy after chemotherapy in patients with advanced testicular cancer // Int Urol Nephrol. 2001;32 (4):665–7.
13. Brown J A, Bihrle R, and. Foster RS: Delayed orchiectomy at postchemotherapy retroperitoneal lymph node dissection due to laterality of retroperitoneal metastatic pattern consistent with testicular primary: assessment of pathologic findings // Urology. 2008;71: 911–914.
14. Fedyanin M, Tryakin A, Titov D, T. Zakharova, I. Fainstein, K. Figurin, et al.: Importance of maintenance of dose intensity (DI) during induction chemotherapy (iCT) for metastatic nonseminomatous germ cell tumors (NSGCT) // J Clin Oncol 27, 2009 (suppl; abstr e16063).
15. Ramani VA, Grey BR, Addla SK, Dunham MP, Sangar VK, Clarke NW. Histological outcome of delayed orchidectomy after primary chemotherapy for metastatic germ cell tumour of the testis // Clin Oncol (R Coll Radiol). 2008 Apr;20 (3):247–52.
Review
For citations:
Fedyanin M.Yu., Tryakin A.A., Bulanov A.A., Fainshtein I.A., Sergeev Yu.S., Matveev V.B., Garin A.M., Tyulyandin S.A. The impact of time of performance of delayed orchiectomy on survival of patients with advanced germ cell tumors of testicles. Malignant tumours. 2014;(2):3-10. (In Russ.) https://doi.org/10.18027/2224-5057-2014-2-3-10
Views:
3268
Email this article 