Metastases to the brain and to the skull base of carcinomas that are rarely metastasize to the central nervous system. Clinical and morphological analysis of 51 cases and literature review
https://doi.org/10.18027/2224-5057-2014-2-24-29
Abstract
Metastases of malignant tumors to the brain represent a severe manifestation of far gone oncological disease. Modern possibilities of combined treatment dictate the requirements for understanding the epidemiology, etiology, pathogenesis and morphology of brain metastases. It has been long observed that certain tumors: breast, lung, colon and kidney cancer and melanoma - are the most frequent origins of the brain metastases. However, other tumors, much less, but are also capable to metastasize to the CNS. In this paper, a detailed clinical and morphological investigation of the brain metastases from the origins different from the most common metastatic tumors of the brain is presented. Karnovskiy index before surgery and presence of non-brain metastases are significant criteria of the prognosis. Literature review is presented in this article.
About the Authors
D. L. Rotin
Московский клинический научный центр
Russian Federation
Russian Federation
M. A. Stepanyan
НИИ нейрохирургии им. Акад. Н. Н. Бурденко РАМН
Russian Federation
Russian Federation
V. A. Cherekaev
НИИ нейрохирургии им. Акад. Н. Н. Бурденко РАМН
Russian Federation
Russian Federation
O. V. Paklina
Городская клиническая больница им. С. П. Боткина, Москва
Russian Federation
Russian Federation
References
1. А. Х. Бекяшев, Н. В. Севян, Д. М. Белов, А. В. Зотов, Ю. В. Цыбульская, Д. Р. Насхлеташвили. Редкий случай метастазирования гепатоцеллюлярного рака в головной мозг. — Опухоли Головы и Шеи — 2012-№ 3 стр. 73–79.
2. Ротин Д. Л., Долгушин М. Б., Пронин И. Н., Шишкина Л.В., Паклина О. В., Сетдикова Г. Р., Никулина Л. А. Метастаз протоковой аденокарциномы поджелудочной железы в головном мозге. — Онкохирургия, 2011, Том 3, № 3, стр. 78–81.
3. Степанян М. А., Ротин Д. Л., Черекаев В.А., Бородин В. В. Метастазы дифференцированного рака щитовидной железы в головной мозг и основание черепа: описание 2 случаев. Опухоли Головы и Шеи, 2011, № 3, стр. 51–55.
4. Agrawal A, Kumar A, Sinha AK, Kumar M, Pandey SR, Khaniya S. Intracranial metastases from carcinoma of the cervix. Singapore Med J. 2007 May; Vol. 48 (5): р. 154–156.
5. Amita M, Sudeep G, Rekha W, Yogesh K, Hemant T. Brain metastasis from cervical carcinoma — a case report. MedGenMed. 2005 Jan Vol. 5;7 (1): p. 26–31.
6. Cui R, Cheng X, Li F, Zhuang H. Rare cerebral and pulmonary metastases from low-grade basal cell adenocarcinoma of the parotid gland. Clin Nucl Med. 2011 Dec; Vol. 36 (12): p. 1124–1126.
7. Gavrilovic IT, Posner JB. Brain metastases: epidemiology and pathophysiology. — J Neurooncol. — 2005. — Oct; Vol. 75 (1): p. 5–14.
8. Gottwald L, Dukowicz A, Spych M, Misiewicz B, Piekarski J, Misiewicz P, Moszynska-Zielinska M, Chalubinska-Fendler J. Central nervous system metastases from epithelial ovarian cancer. J Obstet Gynaecol. 2012. — Aug; Vol. 32 (6): p. 585–589.
9. Ikeda S, Yamada T, Katsumata N, Hida K, Tanemura K, Tsunematu R, Ohmi K, Sonoda T, Ikeda H, Nomura K. Cerebral metastasis in patients with uterine cervical cancer. Jpn J Clin Oncol. 1998 Jan; Vol. 28 (1): p. 27–29.
10. Isoda H, Takahashi M, Arai T, Ramsey RG, Yokoyama T, Mochizuki T, Yamamoto I, Kaneko M. Multiple haemorrhagic brain metastases from papillary thyroid cancer. Neuroradiology. 1997 Mar;39 (3): p. 198–202.
11. Kastritis E, Efstathiou E, Gika D, Bozas G, Koutsoukou V, Papadimitriou C, Pissakas G, Dimopoulos MA, Bamias A. Brain metastases as isolated site of relapse in patients with epithelial ovarian cancer previously treated with platinum and paclitaxel-based chemotherapy. Int J Gynecol Cancer. 2006. — May-Jun; Vol.16 (3): p. 994–999.
12. Mahmoud-Ahmed AS, Kupelian PA, Reddy CA, Suh JH. Brain metastases from gynecological cancers: factors that affect overall survival. Technol Cancer Res Treat. 2002 Aug;1 (4): p. 305–310.
13. Park SH, Ro DY, Park BJ, Kim YW, Kim TE, Jung JK, Lee JW, Kim JY, Han CW. Brain metastasis from uterine cervical cancer. J Obstet Gynaecol Res. — 2010 Jun; Vol. 36 (3): p. 701–704.
14. Pectasides D, Aravantinos G, Fountzilas G, Kalofonos C, Efstathiou E, Karina M, Pavlidis N, Farmakis D, Economopoulos T, Dimopoulos MA. Brain metastases from epithelial ovarian cancer. The Hellenic Cooperative Oncology Group (HeCOG) experience and review of the literature. Anticancer Res. — 2005. — Sep-Oct; Vol. 25 (5): p. 3553–3558.
15. Piura E, Piura B. Brain metastases from ovarian carcinoma. ISRN Oncol. 2011;2011:527453. Epub 2011 Dec 1.
16. Pohl H, Welch HG. The role of overdiagnosis and reclassification in the marked increase of esophageal adenocarcinoma incidence. J Natl Cancer Inst. 2005. — Vol. 97:-р. 142–146.
17. Smith RS, Miller RC. Incidence of brain metastasis in patients with esophageal carcinoma. World J Gastroenterol. 2011. — May 21; Vol. 17 (19): p. 2407–2410.
18. Tamura S, Takeno A, Miki H, Uchiyama C, Kanemura T, Ono H, Hamanaka M, Suzuki R, Nakahira S, Nakata K, Takeda Y. [Clinical outcomes in patients with brain metastasis from gastric cancer]. Gan To Kagaku Ryoho. 2011. — Nov; Vol. 38 (12): p. 2093–2096.
Review
For citations:
Rotin D.L., Stepanyan M.A., Cherekaev V.A., Paklina O.V. Metastases to the brain and to the skull base of carcinomas that are rarely metastasize to the central nervous system. Clinical and morphological analysis of 51 cases and literature review. Malignant tumours. 2014;(2):24-29. (In Russ.) https://doi.org/10.18027/2224-5057-2014-2-24-29
Views:
2069
Email this article 