Preview

Malignant tumours

Advanced search

Radiotherapy after radical prostatectomy: when and for whom?

https://doi.org/10.18027/2224-5057-2013-1-41-46

Abstract

Radical prostatectomy can provide an excellent local control in patients with localized prostate cancer.  However, some patients with risk factors (extracapsular spread of tumor (pT3a), seminal vesicle invasion (pT3b) or the presence of tumor cells in the resection margin (R1), and others.) require postoperative radiation therapy. The most debated issue is the timing of radiotherapy (during postoperative period or delayed, or in case of increasing levels of PSA), as well as the criteria for the selection of candidates for this treatment. The article examines the arguments "pro" and "contra" adjuvant radiotherapy applicable to the conditions and possibilities of Russian oncological hospitals.

About the Authors

N. V. Den’gina
ГУЗ Областной клинический онкологический диспансер, г. Ульяновск. Ульяновский государственный университет, кафедра онкологии и лучевой диагностики.
Russian Federation


S. V. Panchenko
ГУЗ Областной клинический онкологический диспансер, г. Ульяновск. Ульяновский государственный университет, кафедра онкологии и лучевой диагностики.
Russian Federation


V. V. Rodionov
ГУЗ Областной клинический онкологический диспансер, г. Ульяновск. Ульяновский государственный университет, кафедра онкологии и лучевой диагностики.
Russian Federation


References

1. Han M., Partin A. W., Pound C. R., Epstein J. I., Walsh P. C. Long-term biochemical disease-free and cancer-specific survival following anatomic radical retropubic prostatectomy. The 15-year Johns Hopkins experience. Urol Clin North Am. — 2001 Aug;

2. (3): 555-65.

3. Bottke D., de Reijke T. M., Bartkowiak D., Wiegel T. Salvage radiotherapy in patients with persisting / rising PSA after radical prostatectomy for prostate cancer. Eur J Cancer 45:148-157, 2009.

4. Bolla M., Van H. Poppel, Collette L. et al., Postoperative radiotherapy after radical prostatectomy: a randomised controlled trial (EORTC trial 22911). The Lancet, vol. 366, no. 9485, pp. 572-578, 2005.

5. Thompson I. M., Tangen C. M., Paradelo J. et al. Adjuvant radiotherapy for pathologically advanced prostate cancer: a randomized clinical trialю Journal of the American Medical Association, vol. 296, no. 19, pp. 2329-2335, 2006.

6. Wiegel T., Bottke D., Steiner U. et al. Phase III postoperative adjuvant radiotherapy after radical prostatectomy compared with radical prostatectomy alone in pT3 prostate cancer with postoperative undetectable prostate-specific antigen: ARO 96-02 / AUO AP 09 / 95. J Clin Oncol, vol. 27, no.18, pp. 2924-2930, 2009.

7. Catton C., Gospodarowicz M., Warde P., Panzarella T., Catton P., McLean M., Milosevic M. Adjuvant and salvage radiation therapy after radical prostatectomy for adenocarcinoma of the prostate. Radiother Oncol. 2001 Apr; 59 (1): 51-60.

8. Partin A. W., Oesterling J. E.. The clinical usefulness of prostate specific antigen: update. — 1994. J Urol. 1994; 152: 1358-68.

9. Trabulsi E. J., Valicenti R. K., Hanlon A. L. et al. A multi-institutional matched-control analysis of adjuvant and salvage postoperative radiation therapy for pT3-4N0 prostate cancer. Urology. — 2008 Dec; 72 (6): 1298-302.

10. Fernando P. Secin, Caroline Savage, Claude Abbou et al. The Learning Curve for Laparoscopic Radical Prostatectomy: An International Multicenter Study. J Urol. — 2010, December; 184 (6): 2291-2296

11. Stephenson A. J., Scardino P. T., Kattan M. W. et al. Predicting the outcome of salvage radiation therapy for recurrent prostate cancer after radical prostatectomy. J Clin Oncol. — 2007; 25: 2035-41.

12. Bianco F. J. Jr, Scardino P. T., Eastham J. A.. Radical prostatectomy: Long-term cancer control and recovery of sexual and urinary function («trifecta»). Urology. — 2005; 66: 83-94.

13. Pound C. R., Partin A. W., Eisenberger M. A. et al. Natural history of progression after PSA elevation following radical prostatectomy. JAMA. — 1999; 281: 1591-1597.

14. Collette L., vsn Poppel H., Bolla M. et al. Patients at high risk of progression after radical prostatectomy: Do they all benefit from immediate post-operative irradiation? (EORTC trial 22911) Eur J Cancer 41: 2662-2672, 2005.

15. Gregory P. Swanson, Joseph W. Basler. Prognostic Factors for Failure after Prostatectomy. J Cancer 2011; 2: 1-19.


Review

For citations:


Den’gina N.V., Panchenko S.V., Rodionov V.V. Radiotherapy after radical prostatectomy: when and for whom? Malignant tumours. 2013;(1):41-46. (In Russ.) https://doi.org/10.18027/2224-5057-2013-1-41-46

Views: 3389


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2224-5057 (Print)
ISSN 2587-6813 (Online)