Preview

Malignant tumours

Advanced search

Multiple post-radiation angiosarcoma of the breast: rare clinical case

https://doi.org/10.18027/2224-5057-2023-13-2-7

Abstract

This article describes the rare clinical case of multiple radiation-induced angiosarcoma of the breast. Angiosarcoma is a rare, aggressive tumor originating from the endothelial cells of blood vessels that can affect internal organs, but the most common localization is the skin. The frequency of angiosarcoma development in the mammary gland is less than 1% of all malignant tumors of this localization. There are primary and radiation-induced (secondary) angiosarcomas. The reason for describing this clinical case is the rarity of this pathology, relatively little experience in the diagnosis and treatment of radiation-induced angiosarcoma both in our country and abroad.

About the Authors

E. K. Saribekyan
P.A. Herzen Moscow Oncology Research Institute
Russian Federation

Erik K. Saribekyan - MD, PhD, DSc, Leading researcher, Department of Oncology and Reconstructive Plastic Surgery of the Breast and Skin, P.A. Herzen Moscow Oncology Research Institute.

Moscow


Competing Interests:

None



A. R. Bosieva
P.A. Herzen Moscow Oncology Research Institute; Peoples’ Friendship University of Russia
Russian Federation

Alana R. Bosieva - MD. PhD, Research Fellow, Department of Oncology and Reconstructive Plastic Surgery of the Breast and Skin, P.A. Herzen Moscow Oncology Research Institute, Assistant of the Department of Oncology and X-Ray Radiology named after V.P. Kharchenko, Medical Institute of PFUR.

Moscow


Competing Interests:

None



S. V. Medvedev
P.A. Herzen Moscow Oncology Research Institute
Russian Federation

Sergey V. Medvedev - MD, PhD, Senior Researcher, Department of Neuroradiology, Radiation Therapy Day Hospital, P.A. Herzen Moscow Oncology Research Institute.

Moscow


Competing Interests:

None



D. R. Ortabaeva
P.A. Herzen Moscow Oncology Research Institute
Russian Federation

Dzerassa R. Ortabaeva - oncologist of the polyclinic department, P.A. Herzen Moscow Oncology Research Institute.

Moscow


Competing Interests:

None



E. N. Slavnova
P.A. Herzen Moscow Oncology Research Institute
Russian Federation

Elena N. Slavnova - MD, PhD, DSc, Leading Researcher, Department of Oncocytology, P.A. Herzen Moscow Oncology Research Institute.

Moscow


Competing Interests:

None



V. S. Surkova
P.A. Herzen Moscow Oncology Research Institute; Peoples’ Friendship University of Russia
Russian Federation

Victoria S. Surkova - Pathologist, Pathology Department, P.A. Herzen Moscow Oncology Research Institute.

Moscow


Competing Interests:

None



K. M. Petrunina
P.A. Herzen Moscow Oncology Research Institute
Russian Federation

Kseniya M. Petrunina - Radiologist, Department of Radiation Diagnostics, P.A. Herzen Moscow Oncology Research Institute.

Moscow


Competing Interests:

None



References

1. Ghareeb E.R., Bhargava R., Vargo J.A., Florea A.V., Beriwal S. Primary and radiation-induced breast angiosarcoma : clinicopathologic predictors of outcomes and the impact of adjuvant radiation therapy// Am J Clin Oncol. 2016 ; 39 (5) : 463-467.

2. Smith T. L., Morris C. G., Mendenhall N. P. Angiosarcoma after breast-conserving therapy : long-term disease control and late effects with hyperfractionated accelerated re-irradiation (HART) // Acta Oncol. 2014 ; 53 (2) : 235-241.

3. Fujisawa Y., Yoshino K., Kadono T., Miyagawa T., Nakamura Y. Fujimoto M. Chemoradiotherapy with taxane is superior to conventional surgery and radiotherapy in the management of cutaneous angiosarcoma : a multicentre, retrospective study// Br J Dermatol. 2014 ; 171 (6) : 1493-1500.

4. Bonito F., de Almeida Cerejeira D., Dahlstedt-Ferreira C., Oliveira Coelho H., Rosas R. Radiationinduced angiosarcoma of the breast : A review// Breast J. 2019 ; 00 : 1-6. https://doi.org/10.1111/tbj.13504.

5. Колядина И. В., Кометова В. В., Бикеев Ю. В. и др. Радиоиндуцированная ангиосаркома молочной железы : особенности диагностики и лечения (описание клинического случая и данные литературы). Опухоли женской репродуктивной системы 2020 ; 16 (2) : 38-43.

6. Seinen J. M., Styring E., Verstappen V. et al. Radiation-associated angiosarcoma after breast cancer : high recurrence rate and poor survival despite surgical treatment with R0 resection// Ann Surg Oncol. 2012 ; 19 (8) : 2700-2706.

7. Depla A. L., Scharloo-Karels C.H., de Jong M. et al. Treatment and prognostic factors of radiation-associated angiosarcoma (RAAS) after primary breast cancer : a systematic review. Eur J Cancer. 2014 ; 50 (10) : 1779-1788.

8. Uryvaev A., Moskovitz M., Abdach-Bortnyak R., Hershkovitz D., Fried G. Post-irradiation angiosarcoma of the breast : clinical presentation and outcome in a series of six cases. Breast Cancer Res Treat. 2015 ; 153 (1) : 3-8.

9. Mentzel T., Schildhaus H. U., Palmedo G., Buttner R., Kutzner H. Postradiation cutaneous angiosarcoma after treatment of breast carcinoma is characterized by MYC amplification in contrast to atypical vascular lesions after radiotherapy and control cases : clinicopathological, immunohistochemical and molecular analysis of 66 cases. Mod Pathol. 2012 ; 25 (1) : 75-85.

10. Shah S., Rosa M. Radiation-associated angiosarcoma of the breast : clinical and pathologic features// Arch Pathol Lab Med .- 2016 ; 140 (5) : 477-481.

11. Gutkin Paulina M., Ganjoo Kristen N. ; Lohman Marti ; von Eyben, Rie ; Charville, Gregory W. ; Nazerali, Rahim S. ; Dirbas, Frederick M. ; Horst, Kathleen C. (2020). Angiosarcoma of the Breast // American Journal of Clinical Oncology .- 2020 .- doi :10.1097/coc.0000000000000753.

12. Hindley A. C. Re-irradiation of the Breast for Angiosarcoma// Clinical Oncology, 33 (3), e200 .- 2021. doi:10.1016/j.clon.2020.12.015.

13. Linthorst M. van Geel A. N., Baartman E.A. et al. Effect of a combined surgery, re-irradiation and hyperthermia therapy on local control rate in radio-induced angiosarcoma of the chest wall. Strahlenther// Onkol. 2013 ; 189 (5) : 387-393.

14. Wei Nicholas J.J. ; Crowley Timothy P. ; Ragbir Maniram. Early Breast Angiosarcoma Development After Radiotherapy// Annals of Plastic Surgery .- 2019 .- 83 (2), 152-153. doi: 10.1097/sap.0000000000001856.

15. Hung J., Hiniker S. M., Lucas D. R. et al., Sporadic versus radiation-associated angiosarcoma : a comparative clinico-pathologic and molecular analysis of 48 cases, Sarcom (9) (2013) 1-5.

16. Feigenberg S.J., Price Mendenhall N., Reith J.D., et al., Angiosarcoma after breastconserving therapy : experience with hyperfractionated radiotherapy// Int.J. Radiat. Oncol. Biol. Phys. 52 (3) (2002) 620-626.

17. Verdura V. et al. A new case of radiation-induced breast angiosarcoma// International Journal of Surgery Case Reports .- 2019 .- 152-155.


Review

For citations:


Saribekyan E.K., Bosieva A.R., Medvedev S.V., Ortabaeva D.R., Slavnova E.N., Surkova V.S., Petrunina K.M. Multiple post-radiation angiosarcoma of the breast: rare clinical case. Malignant tumours. 2023;13(2):99-106. (In Russ.) https://doi.org/10.18027/2224-5057-2023-13-2-7

Views: 576


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2224-5057 (Print)
ISSN 2587-6813 (Online)