<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">tumors</journal-id><journal-title-group><journal-title xml:lang="ru">Malignant tumours</journal-title><trans-title-group xml:lang="en"><trans-title>Malignant tumours</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2224-5057</issn><issn pub-type="epub">2587-6813</issn><publisher><publisher-name>Rosoncoweb</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18027/2224-5057-2020-10-3-34-39</article-id><article-id custom-type="elpub" pub-id-type="custom">tumors-819</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ И АНАЛИТИКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS AND ANALYSIS</subject></subj-group></article-categories><title-group><article-title>Междисциплинарный интегративный подход к ведению беременности при доброкачественных и пограничных опухолях яичника: клинический случай и обзор литературы</article-title><trans-title-group xml:lang="en"><trans-title>An interdisciplinary integrative approach to pregnancy management in benign and borderline ovarian tumors: a case report and а literature review</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козырко</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozyrko</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елена В. Козырко, к. м. н., научный сотрудник акушерского отделения</p></bio><bio xml:lang="en"><p>Elena V. Kozyrko, Researcher, Researcher, Obstetrics Department</p><p>Moscow</p></bio><email xlink:type="simple">lenochka525@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алиева</surname><given-names>Г. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Alieva</surname><given-names>G. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гульнара Р. кызы Алиева, ординатор 2- го года обучения</p><p>Москва</p></bio><bio xml:lang="en"><p>Gulnara R. kyzy Alieva, 2nd year Resident</p><p>Moscow</p></bio><email xlink:type="simple">gulnara_alieva_08@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ахмедова</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Akhmedova</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аминат И. Ахмедова, к. м. н., врач 1-го акушерского физиологического отделения</p><p>Москва</p></bio><bio xml:lang="en"><p>Aminat I. Akhmedova, MD, PhD, oncologist, Obstetric Physiological Department</p><p>Moscow</p></bio><email xlink:type="simple">akhmedovag@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хохлова</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Khokhlova</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Светлана В. Хохлова, д. м. н., заведующая онкологическим отделением противоопухолевой лекарственной терапии</p><p>Москва</p></bio><bio xml:lang="en"><p>Svetlana V. Khokhlova, Head of the Oncology Department, Anticancer Drug Therapy</p><p>Moscow</p></bio><email xlink:type="simple">s_hohlova@oparina4.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шмаков</surname><given-names>Р. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Shmakov</surname><given-names>R. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Роман Г. Шмаков, д. м. н., профессор РАН, директор института акушерства</p><p>Москва</p></bio><bio xml:lang="en"><p>Roman G. Shmakov, Director, Institute of Obstetrics</p><p>Moscow</p></bio><email xlink:type="simple">r_shmakov@oparina4.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «НМИЦ акушерства, гинекологии и перинатологии имени академика В. И. Кулакова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>12</day><month>06</month><year>2021</year></pub-date><volume>10</volume><issue>3</issue><fpage>34</fpage><lpage>39</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Козырко Е.В., Алиева Г.Р., Ахмедова А.И., Хохлова С.В., Шмаков Р.Г., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Козырко Е.В., Алиева Г.Р., Ахмедова А.И., Хохлова С.В., Шмаков Р.Г.</copyright-holder><copyright-holder xml:lang="en">Kozyrko E.V., Alieva G.R., Akhmedova A.I., Khokhlova S.V., Shmakov R.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.malignanttumors.org/jour/article/view/819">https://www.malignanttumors.org/jour/article/view/819</self-uri><abstract><p>Ведение и лечение пациенток с онкологическими заболеваниями на фоне беременности сегодня представляется очень актуальной проблемой. Среди всех онкологических заболеваний, выявляемых при беременности, опухоли яичников занимают 4 место. Цель исследования — изучить междисциплинарный интегративный подход к ведению беременности при доброкачественных и пограничных опухолях яичника.В статье представлены данные по анализу течения беременности у женщин с пограничными и злокачественными опухолями яичников.При обнаружении опухолей во время беременности акушерская и хирургическая тактика определяются индивидуально совместно с онкологом.При пограничных опухолях, а также злокачественных опухолях Iа стадии возможно не только пролонгирование данной беременности без дополнительного химиотерапевтического лечения, но и сохранение фертильности в дальнейшем.</p></abstract><trans-abstract xml:lang="en"><p>The management and treatment of patients with various malignancies during pregnancy appears to be a pressing issue to date. Ovarian tumors take the 4th place among all neoplasms diagnosed during pregnancy. The study aimed to investigate an interdisciplinary integrative approach to pregnancy management in case of benign and borderline ovarian tumors.The article presents the analysis of the pregnancy course in women with borderline and malignant ovarian tumors. When detecting a tumor during pregnancy, obstetric and surgical tactics is determined in a multidisciplinary team together with an oncologist.It is possible not only to prolong pregnancy without additional chemotherapy but also to preserve fertility in the future in patients with borderline tumors and stage I malignant tumors.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>беременность</kwd><kwd>опухоли яичников</kwd><kwd>злокачественные новообразования</kwd><kwd>комплексное лечение</kwd><kwd>консервативное лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pregnancy</kwd><kwd>ovarian tumors</kwd><kwd>malignant neoplasms</kwd><kwd>complex treatment</kwd><kwd>conservative treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Andrijono. Kanker Ovarium. Dalam: Sinopsis Kanker Ginekologi. Edisi Keempat. Jakarta: Balai Penerbit Fakultas Kedokteran Universitas Indonesia, 2013.</mixed-citation><mixed-citation xml:lang="en">Andrijono. Kanker Ovarium. Dalam: Sinopsis Kanker Ginekologi. Edisi Keempat. Jakarta: Balai Penerbit Fakultas Kedokteran Universitas Indonesia, 2013.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">WHO: International Agency for Research on Cancer. Globocan 2012: Estimated Cancer Incidence, Mortality, Prevalence Worldwide in 2012. [Cited 2017 December 10]. Available from: http://globocan.iarc.fr/Pages/fact_sheets_population.aspx.2012</mixed-citation><mixed-citation xml:lang="en">WHO: International Agency for Research on Cancer. Globocan 2012: Estimated Cancer Incidence, Mortality, Prevalence Worldwide in 2012. [Cited 2017 December 10]. Available from: http://globocan.iarc.fr/Pages/fact_sheets_population.aspx.2012</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">The world ovarian cancer coalition atlas. Global trends in incidence, mortality and surviva. World Ovarian Cancer Coalition 2020. Author Frances Reid Programme Director, World Ovarian Cancer Coalition Reviewers Dr Manas Chakrabarti Diane Gardiner Robyn Maxwell. P. 4–7</mixed-citation><mixed-citation xml:lang="en">The world ovarian cancer coalition atlas. Global trends in incidence, mortality and surviva. World Ovarian Cancer Coalition 2020. Author Frances Reid Programme Director, World Ovarian Cancer Coalition Reviewers Dr Manas Chakrabarti Diane Gardiner Robyn Maxwell. P. 4–7</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">This report has been produced and funded by the World Ovarian Cancer Coalition © World Ovarian Cancer Coalition 2018 Study Director: Frances Reid Expert Advisory Panel Co ‑ Chairs: Professor Neerja Bhatla and Annwen Jones l April 2018. P. 7–10</mixed-citation><mixed-citation xml:lang="en">This report has been produced and funded by the World Ovarian Cancer Coalition © World Ovarian Cancer Coalition 2018 Study Director: Frances Reid Expert Advisory Panel Co ‑ Chairs: Professor Neerja Bhatla and Annwen Jones l April 2018. P. 7–10</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Оncological management and obstetric and neonatal outcomes for women diagnosed with cancer during pregnancy: a 20‑year international cohort study of 1170 patients de Haan J., Verheecke M., Han S. N., Amant F., Van Calsteren K., Van Calster B., de Groot C. J. M., Shmakov R. G., Polushkina E., Sukhikh G. T., Mhallem Gziri M., Halaska M. J., Rob L., Fruscio R., Ceppi L., Lok C. A. R., Boere I. A., Zola P., Ottevanger P. B., Peccatori F. A. et al. The Lancet Oncology. 2018. Т. 19. № 3. С. 337–346.</mixed-citation><mixed-citation xml:lang="en">Оncological management and obstetric and neonatal outcomes for women diagnosed with cancer during pregnancy: a 20‑year international cohort study of 1170 patients de Haan J., Verheecke M., Han S. N., Amant F., Van Calsteren K., Van Calster B., de Groot C. J. M., Shmakov R. G., Polushkina E., Sukhikh G. T., Mhallem Gziri M., Halaska M. J., Rob L., Fruscio R., Ceppi L., Lok C. A. R., Boere I. A., Zola P., Ottevanger P. B., Peccatori F. A. et al. The Lancet Oncology. 2018. Т. 19. № 3. С. 337–346.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Goff B. A., Mandel L. S., Melancon C. H., Muntz H. G. Fre‑ quency of symptoms of ovarian cancer in women presenting to primary care clinics / / JAMA.— 2004.— Vol. 291.— P. 2705.</mixed-citation><mixed-citation xml:lang="en">Goff B. A., Mandel L. S., Melancon C. H., Muntz H. G. Fre‑ quency of symptoms of ovarian cancer in women presenting to primary care clinics / / JAMA.— 2004.— Vol. 291.— P. 2705.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Goff B. A., Mandel L. S., Drescher C. W. et al. Develop ‑ment of an ovarian cancer symptom index: possibilities for earlier detection / / Cancer.— 2007.— Vol. 109.— P. 221</mixed-citation><mixed-citation xml:lang="en">Goff B. A., Mandel L. S., Drescher C. W. et al. Develop ‑ment of an ovarian cancer symptom index: possibilities for earlier detection / / Cancer.— 2007.— Vol. 109.— P. 221</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Серов В. Н. Шмаков Р. Г. Полушкина Е. С., Волочаева М. В. Рак и беременность / / РМЖ. Мать и дитя. 2015. № 20. С. 1195–1197.</mixed-citation><mixed-citation xml:lang="en">Серов В. Н. Шмаков Р. Г. Полушкина Е. С., Волочаева М. В. Рак и беременность / / РМЖ. Мать и дитя. 2015. № 20. С. 1195–1197.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">de Haan J, Vandecaveye V, Han SN, Van de Vijver KK, Amant F. Difficulties with diagnosis of malignancies in pregnancy / / Best Pract Res Clin Obstet Gynaecol. 2016. Vol. 33. P. 19–32.</mixed-citation><mixed-citation xml:lang="en">de Haan J, Vandecaveye V, Han SN, Van de Vijver KK, Amant F. Difficulties with diagnosis of malignancies in pregnancy / / Best Pract Res Clin Obstet Gynaecol. 2016. Vol. 33. P. 19–32.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Martínez MT, Bermejo B, Hernando C, Gambardella V, Cejalvo JM, Lluch A. Breast cancer in pregnant patients: A review of the literature / / Eur J Obstet Gynecol Reprod Biol. 2018. Vol. 230. P. 222–22</mixed-citation><mixed-citation xml:lang="en">Martínez MT, Bermejo B, Hernando C, Gambardella V, Cejalvo JM, Lluch A. Breast cancer in pregnant patients: A review of the literature / / Eur J Obstet Gynecol Reprod Biol. 2018. Vol. 230. P. 222–22</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Maggen C, van Gerwen M, Van Calsteren K, Vandenbroucke T, Amant F. Management of cancer during pregnancy and current evidence of obstetric, neonatal and pediatric outcome: a review article / / Int J Gynecol Cancer. 2019. Vol. 29. P. 404–416.</mixed-citation><mixed-citation xml:lang="en">Maggen C, van Gerwen M, Van Calsteren K, Vandenbroucke T, Amant F. Management of cancer during pregnancy and current evidence of obstetric, neonatal and pediatric outcome: a review article / / Int J Gynecol Cancer. 2019. Vol. 29. P. 404–416.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Peccatori FA, Azim HA Jr, Orecchia R, Hoekstra HJ, Pavlidis N, Kesic V, Pentheroudakis G; ESMO Guidelines Working Group. Сancer, pregnancy and fertility: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow‑up / / Ann Oncol. 2013. Vol. 24. № 6. P. Р. vi160–170</mixed-citation><mixed-citation xml:lang="en">Peccatori FA, Azim HA Jr, Orecchia R, Hoekstra HJ, Pavlidis N, Kesic V, Pentheroudakis G; ESMO Guidelines Working Group. Сancer, pregnancy and fertility: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow‑up / / Ann Oncol. 2013. Vol. 24. № 6. P. Р. vi160–170</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Hsieh TC1, Wu YC, Sun SS, Chu LY, Yen KY, Kao CH. FDG PET / CT of a late‑term pregnant woman with breast cancer / / Clin Nucl Med. 2012. Vol. 37. № 5. P. 489–491.</mixed-citation><mixed-citation xml:lang="en">Hsieh TC1, Wu YC, Sun SS, Chu LY, Yen KY, Kao CH. FDG PET / CT of a late‑term pregnant woman with breast cancer / / Clin Nucl Med. 2012. Vol. 37. № 5. P. 489–491.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Takalkar AM, Khandelwal A, Lokitz S, Lilien DL, Stabin MG. 18F-FDG PET in Pregnancy and Fetal Radiation Dose Estimates / / J Nucl Med. 2011. Vol. 52. № 7. P. 1035–1040</mixed-citation><mixed-citation xml:lang="en">Takalkar AM, Khandelwal A, Lokitz S, Lilien DL, Stabin MG. 18F-FDG PET in Pregnancy and Fetal Radiation Dose Estimates / / J Nucl Med. 2011. Vol. 52. № 7. P. 1035–1040</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Кузнецов В. В. Диагностика метастатического поражения скелета / / Тюменский мед журнал. 2013. Т. 15. № 4. С. 31–3</mixed-citation><mixed-citation xml:lang="en">Кузнецов В. В. Диагностика метастатического поражения скелета / / Тюменский мед журнал. 2013. Т. 15. № 4. С. 31–3</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ray JG, Vermeulen MJ, Bharatha A, Montanera WJ, Park AL. Association between MRI exposure during pregnancy and fetal and childhood outcomes / / JAMA. 2016. Vol. 316. № 9. Р. 952–961</mixed-citation><mixed-citation xml:lang="en">Ray JG, Vermeulen MJ, Bharatha A, Montanera WJ, Park AL. Association between MRI exposure during pregnancy and fetal and childhood outcomes / / JAMA. 2016. Vol. 316. № 9. Р. 952–961</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Леваков С. А., Боровкова Е. И. Особенности течения рака молочной железы в сочетании с беременностью (обзор литературы) / / Акушерство и гинекология: новости, мнения, обучение. 2014. № 2 (4). С. 88, 91–96.</mixed-citation><mixed-citation xml:lang="en">Леваков С. А., Боровкова Е. И. Особенности течения рака молочной железы в сочетании с беременностью (обзор литературы) / / Акушерство и гинекология: новости, мнения, обучение. 2014. № 2 (4). С. 88, 91–96.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Zubor P, Kubatka P, Kapustova I, Miloseva L, Dankova Z, Gondova A, Bielik T, Krivus S, Bujnak J, Laucekova Z, Kehrer C, Kudela E, Danko J. Current approaches in the clinical management of pregnancy‑associated breast cancer‑pros and cons // EPMA J. 2018. Vol. 9. № 3. P. 257‑270</mixed-citation><mixed-citation xml:lang="en">Zubor P, Kubatka P, Kapustova I, Miloseva L, Dankova Z, Gondova A, Bielik T, Krivus S, Bujnak J, Laucekova Z, Kehrer C, Kudela E, Danko J. Current approaches in the clinical management of pregnancy‑associated breast cancer‑pros and cons // EPMA J. 2018. Vol. 9. № 3. P. 257‑270</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
