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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">tumors</journal-id><journal-title-group><journal-title xml:lang="ru">Malignant tumours</journal-title><trans-title-group xml:lang="en"><trans-title>Malignant tumours</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2224-5057</issn><issn pub-type="epub">2587-6813</issn><publisher><publisher-name>Rosoncoweb</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18027/2224-5057-2019-10-3s1-3-10</article-id><article-id custom-type="elpub" pub-id-type="custom">tumors-724</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL REPORTS</subject></subj-group></article-categories><title-group><article-title>Выбор объема хирургического лечения у больных раком тела матки</article-title><trans-title-group xml:lang="en"><trans-title>Выбор объема хирургического лечения у больных раком тела матки</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нечушкина</surname><given-names>В. М.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><email xlink:type="simple">drnechushkina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Морхов</surname><given-names>К. Ю.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Егорова</surname><given-names>А. В.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГБУ «НМИЦ АГП им. В. И. Кулакова» Минздрава России; ФГАОУ ВО «РНИМУ им. Н. И. Пирогова» Минздрава России</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>ФГБУ «НМИЦ АГП им. В. И. Кулакова» Минздрава России</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-3"><institution>ФГАОУ ВО «РНИМУ им. Н. И. Пирогова» Минздрава России</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>02</day><month>12</month><year>2020</year></pub-date><volume>10</volume><issue>3s1</issue><fpage>3</fpage><lpage>10</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Нечушкина В.М., Морхов К.Ю., Егорова А.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Нечушкина В.М., Морхов К.Ю., Егорова А.В.</copyright-holder><copyright-holder xml:lang="en">Нечушкина В.М., Морхов К.Ю., Егорова А.В.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.malignanttumors.org/jour/article/view/724">https://www.malignanttumors.org/jour/article/view/724</self-uri><abstract><p>Статья посвящена вопросам хирургического лечения рака тела матки. Непрекращающиеся в течение нескольких десятилетий дискуссии относительно объема хирургических вмешательств при раке тела матки ранних стадий теперь распространились и на хирургическое лечение диссеминированных форм заболевания. В статье обсуждаются показания к лимфаденэктомии и ее объем, перспективы циторедуктивных операций при диссеминированном раке тела матки и ряд других вопросов.</p></abstract><trans-abstract xml:lang="en"><p>Статья посвящена вопросам хирургического лечения рака тела матки. Непрекращающиеся в течение нескольких десятилетий дискуссии относительно объема хирургических вмешательств при раке тела матки ранних стадий теперь распространились и на хирургическое лечение диссеминированных форм заболевания. В статье обсуждаются показания к лимфаденэктомии и ее объем, перспективы циторедуктивных операций при диссеминированном раке тела матки и ряд других вопросов.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рак тела матки</kwd><kwd>тазовая лимфаденэктомия</kwd><kwd>поясничная лимфаденэктомия</kwd><kwd>адъювантная лучевая терапия</kwd><kwd>циторедуктивные операции</kwd></kwd-group><kwd-group xml:lang="en"><kwd>рак тела матки</kwd><kwd>тазовая лимфаденэктомия</kwd><kwd>поясничная лимфаденэктомия</kwd><kwd>адъювантная лучевая терапия</kwd><kwd>циторедуктивные операции</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бохман Я. В. Метастазы рака матки.— Л.: Медицина, 1976.— 159 с.</mixed-citation><mixed-citation xml:lang="en">Бохман Я. В. Метастазы рака матки.— Л.: Медицина, 1976.— 159 с.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации Министерства здравоохранения Российской Федерации «Рак тела матки и саркомы матки 2020 [Электронный ресурс].— Москва: Министерство здравоохранения Российской Федерации, 2020.— URL: http://cr.rosminzdrav.ru/#!/schema / 320 (дата обращения 01.10.2020).</mixed-citation><mixed-citation xml:lang="en">Клинические рекомендации Министерства здравоохранения Российской Федерации «Рак тела матки и саркомы матки 2020 [Электронный ресурс].— Москва: Министерство здравоохранения Российской Федерации, 2020.— URL: http://cr.rosminzdrav.ru/#!/schema / 320 (дата обращения 01.10.2020).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Нечушкина, В. М. Рак тела матки (факторы прогноза и тактика лечения): дис. … д-ра мед. наук: 14.01.12 / Нечушкина Валентина Михайловна.— М., 2013.— 445 с.</mixed-citation><mixed-citation xml:lang="en">Нечушкина, В. М. Рак тела матки (факторы прогноза и тактика лечения): дис. … д-ра мед. наук: 14.01.12 / Нечушкина Валентина Михайловна.— М., 2013.— 445 с.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Нечушкина В. М., Кузнецов В. В., Баринов В. В., Бокина Л. И. Рак тела матки / М. И. Давыдов, В. В. Кузнецов, В. М. Нечушкина (ред.) Лекции по онкогинекологии.— М.: МЕДпресс-информ, 2009.— С. 226–254.</mixed-citation><mixed-citation xml:lang="en">Нечушкина В. М., Кузнецов В. В., Баринов В. В., Бокина Л. И. Рак тела матки / М. И. Давыдов, В. В. Кузнецов, В. М. Нечушкина (ред.) Лекции по онкогинекологии.— М.: МЕДпресс-информ, 2009.— С. 226–254.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Нечушкина В. М., Коломиец Л. А., Кравец О. А. и соавт. Практические рекомендации по лекарственному лечению лечению рака тела матки и сарком матки // Злокачественные опухоли.— 2019.— Т. 9, Т 3 (прил. 2).— С. 218–232.</mixed-citation><mixed-citation xml:lang="en">Нечушкина В. М., Коломиец Л. А., Кравец О. А. и соавт. Практические рекомендации по лекарственному лечению лечению рака тела матки и сарком матки // Злокачественные опухоли.— 2019.— Т. 9, Т 3 (прил. 2).— С. 218–232.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Нечушкина В. М., Морхов К. Ю., Кузнецов В. В. Адъювантная терапия при раке тела матки ранних стадий // Вестн. РОНЦ им. Н. Н. Блохина РАМН.— 2012.— Т. 23, № 4.— С. 33–40.</mixed-citation><mixed-citation xml:lang="en">Нечушкина В. М., Морхов К. Ю., Кузнецов В. В. Адъювантная терапия при раке тела матки ранних стадий // Вестн. РОНЦ им. Н. Н. Блохина РАМН.— 2012.— Т. 23, № 4.— С. 33–40.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Нечушкина В. М., Морхов К. Ю., Кузнецов В. В. Тазовая и по- ясничная лимфаденэктомия при раке тела матки // Вестн. РОНЦ им. Н. Н. Блохина РАМН.— 2012.— Т. 23, № 2.— С. 64–80.</mixed-citation><mixed-citation xml:lang="en">Нечушкина В. М., Морхов К. Ю., Кузнецов В. В. Тазовая и по- ясничная лимфаденэктомия при раке тела матки // Вестн. РОНЦ им. Н. Н. Блохина РАМН.— 2012.— Т. 23, № 2.— С. 64–80.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Нечушкина В. М., Морхов К. Ю., Кузнецов В. В., Егорова А. В. Адъювантная дистанционная лучевая терапия при раке тела матки I — II стадий // Онкогинекология.— 2014.— № 4.— С. 37–44.</mixed-citation><mixed-citation xml:lang="en">Нечушкина В. М., Морхов К. Ю., Кузнецов В. В., Егорова А. В. Адъювантная дистанционная лучевая терапия при раке тела матки I — II стадий // Онкогинекология.— 2014.— № 4.— С. 37–44.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Aalders J., Abeler V., Kolstad P., Onsrud M. Postoperative external irradiation and prognostic parameters in stage I endometrial carcinoma: clinical and histopathologic study of 540 patients // Obstet. Gynecol.— 1980.— Vol. 56, N 4.— P. 419–427.</mixed-citation><mixed-citation xml:lang="en">Aalders J., Abeler V., Kolstad P., Onsrud M. Postoperative external irradiation and prognostic parameters in stage I endometrial carcinoma: clinical and histopathologic study of 540 patients // Obstet. Gynecol.— 1980.— Vol. 56, N 4.— P. 419–427.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">ASTEC study group, Kitchener H., Swart A. M. et al. Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study // Lancet.— 2009.— Vol. 373, N 9658.— P. 125–136.</mixed-citation><mixed-citation xml:lang="en">ASTEC study group, Kitchener H., Swart A. M. et al. Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study // Lancet.— 2009.— Vol. 373, N 9658.— P. 125–136.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Benedetti Panici P., Basile S., Maneschi F. et al. Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial // J. Natl. Cancer Inst.— 2008.— Vol. 100, N 23.— P. 1707–1716.</mixed-citation><mixed-citation xml:lang="en">Benedetti Panici P., Basile S., Maneschi F. et al. Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial // J. Natl. Cancer Inst.— 2008.— Vol. 100, N 23.— P. 1707–1716.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Bristow R. E., Zerbe M. J., Rosenshein N. B. et al. Stage IVB endometrial carcinoma: the role of cytoreductive surgery and determinants of survival // Gynecol. Oncol.— 2000.— Vol. 78.— P. 85–91.</mixed-citation><mixed-citation xml:lang="en">Bristow R. E., Zerbe M. J., Rosenshein N. B. et al. Stage IVB endometrial carcinoma: the role of cytoreductive surgery and determinants of survival // Gynecol. Oncol.— 2000.— Vol. 78.— P. 85–91.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Buda A., Di Martino G., Restaino S. et al. The impact on survival of two different staging strategies in apparent early stage endometrial cancer comparing sentinel lymph nodes mapping algorithm and selective lymphadenectomy: An Italian retrospective analysis of two reference centers // Gynecol. Oncol.— 2017.— Vol. 147, N 3.— P. 528–534.</mixed-citation><mixed-citation xml:lang="en">Buda A., Di Martino G., Restaino S. et al. The impact on survival of two different staging strategies in apparent early stage endometrial cancer comparing sentinel lymph nodes mapping algorithm and selective lymphadenectomy: An Italian retrospective analysis of two reference centers // Gynecol. Oncol.— 2017.— Vol. 147, N 3.— P. 528–534.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Chan J. K., Cheung M. K., Huh W. K. et al. Therapeutic role of lymph node resection in endometrioid corpus cancer. A Study of 12,333 // Cancer.— 2006.— Vol. 107, N 8.— P. 1823–1830.</mixed-citation><mixed-citation xml:lang="en">Chan J. K., Cheung M. K., Huh W. K. et al. Therapeutic role of lymph node resection in endometrioid corpus cancer. A Study of 12,333 // Cancer.— 2006.— Vol. 107, N 8.— P. 1823–1830.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Chan J. K., Urban R., Cheung M. K. et al. Lymphadenectomy in endometrioid uterine cancer staging: how many lymph nodes are enough? A study of 11,443 patients // Cancer.— 2007.— Vol. 109, N 12.— P. 2454–2460.</mixed-citation><mixed-citation xml:lang="en">Chan J. K., Urban R., Cheung M. K. et al. Lymphadenectomy in endometrioid uterine cancer staging: how many lymph nodes are enough? A study of 11,443 patients // Cancer.— 2007.— Vol. 109, N 12.— P. 2454–2460.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Chen J.‑R., Chang T.‑C., Fu H.‑C. et al. Outcomes of patients with surgically and pathologically staged IIIA-IVB pure endometrioidtype endometrial cancer // Medicine.— 2016.— Vol. 95.— P. 15.</mixed-citation><mixed-citation xml:lang="en">Chen J.‑R., Chang T.‑C., Fu H.‑C. et al. Outcomes of patients with surgically and pathologically staged IIIA-IVB pure endometrioidtype endometrial cancer // Medicine.— 2016.— Vol. 95.— P. 15.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Chino J. P., Jones E., Berchuk A. et al. The influence of radiation modality and lymph node dissection on survival in early-stage endometrial cancer // Int. J. Radiat. Oncol. Biol. Phys.— 2012.— Vol. 82, N 5.— P. 1872–1879</mixed-citation><mixed-citation xml:lang="en">Chino J. P., Jones E., Berchuk A. et al. The influence of radiation modality and lymph node dissection on survival in early-stage endometrial cancer // Int. J. Radiat. Oncol. Biol. Phys.— 2012.— Vol. 82, N 5.— P. 1872–1879</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Colombo N., Creutzberg C., Amant F. et al. ESMO-ESGO-ESTRO consensus conference on endometrial cancer: Diagnosis, treatment and follow-up // Int. J. Gynecol. Cancer.— 2016.— Vol. 26, N 1.— P. 2–30.</mixed-citation><mixed-citation xml:lang="en">Colombo N., Creutzberg C., Amant F. et al. ESMO-ESGO-ESTRO consensus conference on endometrial cancer: Diagnosis, treatment and follow-up // Int. J. Gynecol. Cancer.— 2016.— Vol. 26, N 1.— P. 2–30.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Cowles T. A., Magrina J. F., Masterson B. J., Capen C. V. Comparison of clinical and surgical staging in patients with endometrial carcinoma // Obstet. Gynecol.— 1985.— Vol. 66, N 3.— P. 413–416.</mixed-citation><mixed-citation xml:lang="en">Cowles T. A., Magrina J. F., Masterson B. J., Capen C. V. Comparison of clinical and surgical staging in patients with endometrial carcinoma // Obstet. Gynecol.— 1985.— Vol. 66, N 3.— P. 413–416.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Creasman W. T., Morrow C. P., Bundy B. N. et al. Surgical pathologic spread patterns of endometrial cancer. A Gynecologic Oncology Group Study // Cancer.— 1987.— Vol. 60, N 8 (suppl.).— P. 2035–2041.</mixed-citation><mixed-citation xml:lang="en">Creasman W. T., Morrow C. P., Bundy B. N. et al. Surgical pathologic spread patterns of endometrial cancer. A Gynecologic Oncology Group Study // Cancer.— 1987.— Vol. 60, N 8 (suppl.).— P. 2035–2041.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Creasman W. T., Odicino F., Maisonneuve P. et al. Carcinoma of the Corpus Uteri // Int. J. Gynaecol. Obstet.— 2006.— Vol. 95 (suppl. 1).— P. S105 — S144.</mixed-citation><mixed-citation xml:lang="en">Creasman W. T., Odicino F., Maisonneuve P. et al. Carcinoma of the Corpus Uteri // Int. J. Gynaecol. Obstet.— 2006.— Vol. 95 (suppl. 1).— P. S105 — S144.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Creutzberg C. L., van Putten W. L., Koper P. C. et al. Surgery and postoperative radiotherapy versus surgery alone for patients with stage 1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. PostOperative Radiation Therapy in Endometrial Carcinoma // Lancet.— 2000.— Vol. 355, N 9213.— P. 1404–1411.</mixed-citation><mixed-citation xml:lang="en">Creutzberg C. L., van Putten W. L., Koper P. C. et al. Surgery and postoperative radiotherapy versus surgery alone for patients with stage 1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. PostOperative Radiation Therapy in Endometrial Carcinoma // Lancet.— 2000.— Vol. 355, N 9213.— P. 1404–1411.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">DiSaia P. J ., Creasman W. T. Management of endometrial adenocarcinoma stage I with surgical staging followed by tailored adjuvant radiation therapy // Clin. Obstet. Gynaecol.— 1986.— Vol. 13, N 4.— P. 751–765.</mixed-citation><mixed-citation xml:lang="en">DiSaia P. J ., Creasman W. T. Management of endometrial adenocarcinoma stage I with surgical staging followed by tailored adjuvant radiation therapy // Clin. Obstet. Gynaecol.— 1986.— Vol. 13, N 4.— P. 751–765.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Eto T., Saito T., Kasamatsu T. et al. Clinicopathological prognostic factors and the role of cytoreduction in surgical stage IVB endometrial cancer: A retrospective multi-institutional analysis of 248 patients in Japan // Gynecol. Oncol.— 2012.— Vol. 127.— P. 338–344.</mixed-citation><mixed-citation xml:lang="en">Eto T., Saito T., Kasamatsu T. et al. Clinicopathological prognostic factors and the role of cytoreduction in surgical stage IVB endometrial cancer: A retrospective multi-institutional analysis of 248 patients in Japan // Gynecol. Oncol.— 2012.— Vol. 127.— P. 338–344.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Ferlay J., Ervik M., Lam F., et al. Global Cancer Observatory: Cancer Today. [Electronic resource].— Lyon, France: International Agency for Research on Cancer, 2018.— URL: https://gco.iarc.fr / today (дата обращения 24.09.2020).</mixed-citation><mixed-citation xml:lang="en">Ferlay J., Ervik M., Lam F., et al. Global Cancer Observatory: Cancer Today. [Electronic resource].— Lyon, France: International Agency for Research on Cancer, 2018.— URL: https://gco.iarc.fr / today (дата обращения 24.09.2020).</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Goff B. A., Riche L. W. Assessment of depth of myometrial invasion in endometrial adenocarcinoma // Gynecol. Oncol.— 1990.— Vol. 38, N 1.— P. 46–48.</mixed-citation><mixed-citation xml:lang="en">Goff B. A., Riche L. W. Assessment of depth of myometrial invasion in endometrial adenocarcinoma // Gynecol. Oncol.— 1990.— Vol. 38, N 1.— P. 46–48.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Havrilesky L. J., Cragun J. M., Calingaert B. et al. Resection of lymph node metastases influences survival in stage IIIC endometrial cancer // Gynecol. Oncol.— 2005.— Vol. 99, N 3.— P. 689–695.</mixed-citation><mixed-citation xml:lang="en">Havrilesky L. J., Cragun J. M., Calingaert B. et al. Resection of lymph node metastases influences survival in stage IIIC endometrial cancer // Gynecol. Oncol.— 2005.— Vol. 99, N 3.— P. 689–695.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Hirahatake K., Hareyama H., Sakuragi N. et al. A clinical and pathologicstudy on para-aortic lymph node metastasis in endometrial carcinoma // J. Surg. Oncol.— 1997.— Vol. 65, N 2.— P. 82–87.</mixed-citation><mixed-citation xml:lang="en">Hirahatake K., Hareyama H., Sakuragi N. et al. A clinical and pathologicstudy on para-aortic lymph node metastasis in endometrial carcinoma // J. Surg. Oncol.— 1997.— Vol. 65, N 2.— P. 82–87.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Hsieh C. H., Chang Chien C. C., Lin H. et al. Can a preoperative CA 125 level be a criterion for full pelvic lymphadenectomy in surgical staging of endometrial cancer? // Gynecol. Oncol.— 2002.— Vol. 86, N 1.— P. 28–33.</mixed-citation><mixed-citation xml:lang="en">Hsieh C. H., Chang Chien C. C., Lin H. et al. Can a preoperative CA 125 level be a criterion for full pelvic lymphadenectomy in surgical staging of endometrial cancer? // Gynecol. Oncol.— 2002.— Vol. 86, N 1.— P. 28–33.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Huang C.‑Y., Ho C.‑M., Chen Y.‑L. et al. Impact of lymphadenectomy in uterine endometrioid carcinoma // EJSO.— 2013.— Vol. 39.— P. 350–357.</mixed-citation><mixed-citation xml:lang="en">Huang C.‑Y., Ho C.‑M., Chen Y.‑L. et al. Impact of lymphadenectomy in uterine endometrioid carcinoma // EJSO.— 2013.— Vol. 39.— P. 350–357.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Jarvet C. T. The spread of benign and malignant endometrium in the lymphatic system with a note on coexisting vascular involvement // Am. J. Obstet. Gynecol.— 1952.— Vol. 64.— P. 780–806.</mixed-citation><mixed-citation xml:lang="en">Jarvet C. T. The spread of benign and malignant endometrium in the lymphatic system with a note on coexisting vascular involvement // Am. J. Obstet. Gynecol.— 1952.— Vol. 64.— P. 780–806.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson N., Cornes P. Survival and recurrent disease af ter postoperative radiotherapy for early endometrial cancer: systematic review and meta-analysis // BJOG.— 2007.— Vol. 114, N 11.— P. 1313–1320.</mixed-citation><mixed-citation xml:lang="en">Johnson N., Cornes P. Survival and recurrent disease af ter postoperative radiotherapy for early endometrial cancer: systematic review and meta-analysis // BJOG.— 2007.— Vol. 114, N 11.— P. 1313–1320.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Keys H. M., Roberts J. A., Brunetto V. L. et al. A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study // Gynecol. Oncol.— 2004.— Vol. 92, N 3.— P. 744–751.</mixed-citation><mixed-citation xml:lang="en">Keys H. M., Roberts J. A., Brunetto V. L. et al. A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study // Gynecol. Oncol.— 2004.— Vol. 92, N 3.— P. 744–751.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Kong A., Johnson N., Kitchener H. C., Lawrie T. A. Adjuvant radiotherapy for stage I endometrial cancer: an updated Cochrane systematic review and meta-analysis / // J. Natl. Cancer Inst.— 2012.— Vol. 104, N 21.— P. 1625–1634.</mixed-citation><mixed-citation xml:lang="en">Kong A., Johnson N., Kitchener H. C., Lawrie T. A. Adjuvant radiotherapy for stage I endometrial cancer: an updated Cochrane systematic review and meta-analysis / // J. Natl. Cancer Inst.— 2012.— Vol. 104, N 21.— P. 1625–1634.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Lewis B. V., Stallworthy J. A., Cowdell R. Adenocarcinoma of the body of the uterus // J. Obstet. Gynaecol. Br. Commonw.— 1970.— Vol. 77, N 4.— P. 343–348.</mixed-citation><mixed-citation xml:lang="en">Lewis B. V., Stallworthy J. A., Cowdell R. Adenocarcinoma of the body of the uterus // J. Obstet. Gynaecol. Br. Commonw.— 1970.— Vol. 77, N 4.— P. 343–348.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Marziale P., Atlante G., Pozzi M. et al. 426 cases of stage I endometrial carcinoma: a clinicopathological analysis // Gynecol. Oncol.— 1989.— Vol. 32, N 3.— P. 278–281.</mixed-citation><mixed-citation xml:lang="en">Marziale P., Atlante G., Pozzi M. et al. 426 cases of stage I endometrial carcinoma: a clinicopathological analysis // Gynecol. Oncol.— 1989.— Vol. 32, N 3.— P. 278–281.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">McMeekin D. S., Lashbrook D., Gold M. et al. Analysis of FIGO stage IIIc endometrial cancer patients // Gynecol. Oncol.— 2001.— Vol. 81, N 2.— P. 273–278.</mixed-citation><mixed-citation xml:lang="en">McMeekin D. S., Lashbrook D., Gold M. et al. Analysis of FIGO stage IIIc endometrial cancer patients // Gynecol. Oncol.— 2001.— Vol. 81, N 2.— P. 273–278.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">McMeekin D. S., Lashbrook D., Gold M. Nodal distribution and its significance in FIGO stage III endometrial cancer // Gynecol. Oncol.— 2001.— Vol. 82, N 2.— P. 375–379.</mixed-citation><mixed-citation xml:lang="en">McMeekin D. S., Lashbrook D., Gold M. Nodal distribution and its significance in FIGO stage III endometrial cancer // Gynecol. Oncol.— 2001.— Vol. 82, N 2.— P. 375–379.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Nout R. A., Smit V. T. H. B. M., Putter H. et al. Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial // Lancet.— 2010.— Vol. 375, N 9717.— P. 816–823.</mixed-citation><mixed-citation xml:lang="en">Nout R. A., Smit V. T. H. B. M., Putter H. et al. Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial // Lancet.— 2010.— Vol. 375, N 9717.— P. 816–823.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Onda T., Yoshikawa H., Mizutani K. et al. Treatment of node-positive endometrial cancer with complete node dissection, chemotherapy and radiation therapy // Br. J. Cancer.— 1997.— Vol. 75, N 12.— P. 1836–1841.</mixed-citation><mixed-citation xml:lang="en">Onda T., Yoshikawa H., Mizutani K. et al. Treatment of node-positive endometrial cancer with complete node dissection, chemotherapy and radiation therapy // Br. J. Cancer.— 1997.— Vol. 75, N 12.— P. 1836–1841.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Onsrud M., Cvancarova M., Hellebust T. P. et al. Long-term outcomes after pelvic radiation for early-stage endometrial cancer // J. Clin. Oncol.— 2013.— Vol. 31, N 31.— P. 3951–3956.</mixed-citation><mixed-citation xml:lang="en">Onsrud M., Cvancarova M., Hellebust T. P. et al. Long-term outcomes after pelvic radiation for early-stage endometrial cancer // J. Clin. Oncol.— 2013.— Vol. 31, N 31.— P. 3951–3956.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Otsuka I., Kubota T., Aso T. Lymphadenectomy and adjuvant therapy in endometrial carcinoma: role of adjuvant chemotherapy // Br. J. Cancer.— 2002.— Vol. 87, N 4.— P. 377–380.</mixed-citation><mixed-citation xml:lang="en">Otsuka I., Kubota T., Aso T. Lymphadenectomy and adjuvant therapy in endometrial carcinoma: role of adjuvant chemotherapy // Br. J. Cancer.— 2002.— Vol. 87, N 4.— P. 377–380.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Shih K. K., Yun E., Gardner G. J. et al. Surgical cytoreduction in stage IV endometrioid endometrial carcinoma // Gynecol. Oncol.— 2011.— Vol. 122.— P. 608–611.</mixed-citation><mixed-citation xml:lang="en">Shih K. K., Yun E., Gardner G. J. et al. Surgical cytoreduction in stage IV endometrioid endometrial carcinoma // Gynecol. Oncol.— 2011.— Vol. 122.— P. 608–611.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Stallworthy J. A. Surgery of endometrial cancer in the Bonney tradition // Ann. R. Coll. Surg. Engl.— 1971.— Vol. 48, N 5.— P. 293–305.</mixed-citation><mixed-citation xml:lang="en">Stallworthy J. A. Surgery of endometrial cancer in the Bonney tradition // Ann. R. Coll. Surg. Engl.— 1971.— Vol. 48, N 5.— P. 293–305.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Straughn J. M., Huh W. K., Kelly F. J. et al. Conservative management of stage I endometrial carcinoma after surgical staging // Gynecol. Oncol.— 2002.— Vol. 84, N 2.— P. 194–200.</mixed-citation><mixed-citation xml:lang="en">Straughn J. M., Huh W. K., Kelly F. J. et al. Conservative management of stage I endometrial carcinoma after surgical staging // Gynecol. Oncol.— 2002.— Vol. 84, N 2.— P. 194–200.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Straughn J. M., Huh W. K., Orr J. W. et al. Stage IC adenocarcinoma of the endometrium: survival comparisons of surgically staged patients with and without adjuvant radiation therapy // Gynecol. Oncol.— 2003.— Vol. 89, N 2.— P. 295–300.</mixed-citation><mixed-citation xml:lang="en">Straughn J. M., Huh W. K., Orr J. W. et al. Stage IC adenocarcinoma of the endometrium: survival comparisons of surgically staged patients with and without adjuvant radiation therapy // Gynecol. Oncol.— 2003.— Vol. 89, N 2.— P. 295–300.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Todo Y., Kato H., Kaneuchi M. et al. Survival effect of paraaortic lymphadenectomy in endometrial cancer (SEPAL study): a retrospective cohort analysis // Lancet.— 2010.— Vol. 375, N 9721.— P. 1165–1172.</mixed-citation><mixed-citation xml:lang="en">Todo Y., Kato H., Kaneuchi M. et al. Survival effect of paraaortic lymphadenectomy in endometrial cancer (SEPAL study): a retrospective cohort analysis // Lancet.— 2010.— Vol. 375, N 9721.— P. 1165–1172.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
