tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2020-10-41-48tumors-708Research ArticleКЛИНИЧЕСКИЕ СЛУЧАИCLINICAL NOTESПрименение ниволумаба при раке толстой кишки с синдромом Линча. Клиническое наблюдениеThe Use of Nivolumab in Colorectal Cancer with Lynch Syndrome. A Case ReportХакимоваГ. Г.KhakimovaG. G.

Гулноз Г. Хакимова, аспирант онкологического отделения лекарственных методов лечения (химиотерапевтическое) № 3

Москва

Gulnoz G. Khakimova, postgraduate student, Department of Drug Therapy in Oncology (Department of Chemotherapy) No. 3

Moscow

hgg_doc@mail.ruТрякинА. А.TryakinA. A.

Алексей А. Трякин, д. м. н., главный научный сотрудник отделения клинической фармакологии и химиотерапии

Москва

Alexey A. Tryakin, MD, PhD, DSc, Senior Researcher, Department of Clinical Pharmacology and Chemotherapy

Moscow

ХакимовГ. А.KhakimovG. A.

Голиб А. Хакимов, д. м. н., проф., директор Ташкентского городского филиала Республиканского специализированного научно-практического центра, заведующий курсом онкологии кафедры хирургии Ташкентского педиатрического медицинского института

Ташкент

Golib A. Khakimov, MD, PhD, DSc, Prof, Director, Tashkent City Branch, Republican Specialized Scientific and Practical Centre, Head, Oncology Course, Department of Surgery

Tashkent

ФГБУ «НМИЦ онкологии им. Н. Н. Блохина» Минздрава РоссииРоссияN. N. Blokhin National Medical Research Center of OncologyRussian FederationФГБУ «НМИЦ онкологии им. Н. Н. Блохина» Минздрава России; ГБУЗ «Московский Клинический Научный Центр им. А. С. Логинова» ДЗМРоссияN. N. Blokhin National Medical Research Center of Oncology; Moscow Clinical Research Centre named after A. S. LoginovRussian FederationТашкентский педиатрический медицинский институт; Республиканский специализированный Научно-практический Медицинский Центр Онкологии и РадиологииУзбекистанTashkent Pediatric Medical Institute; Republican specialized Scientific and practical Medical Center of Oncology and RadiologyUzbekistan2020270720201014148Copyright © Хакимова Г.Г., Трякин А.А., Хакимов Г.А., 20202020Хакимова Г.Г., Трякин А.А., Хакимов Г.А.Khakimova G.G., Tryakin A.A., Khakimov G.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/708

Синдром Линча (СЛ), возникающий в результате нарушений репарации неспаренных оснований ДНК, характеризуется повышенным риском развития рака толстой кишки, эндометрия и мочевыводящих путей. Независимо от типа опухоли, иммунотерапия ингибиторами контрольных точек (ИКТ) была одобрена для лечения пациентов с неоперабельными или метастатическими опухолями с нарушением системы репарации ДНК (dMMR), что может быть опцией для лечения пациентов с СЛ. В статье описывается клиническое наблюдение пациентки с герминальной мутацией MLH1 и с первично-множественными злокачественными образованиями ободочной кишки, получавшей лечение ниволумабом в течение 26 месяцев. Это наблюдение демонстрирует успех иммунотерапии после 6 линий химиотерапии, подразумевая потенциальный контроль опухолевого роста у пациентов с СЛ.

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The authors declare that there are no conflicts of interest present.