<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">tumors</journal-id><journal-title-group><journal-title xml:lang="ru">Malignant tumours</journal-title><trans-title-group xml:lang="en"><trans-title>Malignant tumours</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2224-5057</issn><issn pub-type="epub">2587-6813</issn><publisher><publisher-name>Rosoncoweb</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18027/2224-5057-2012-1-35-39</article-id><article-id custom-type="elpub" pub-id-type="custom">tumors-64</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ И АНАЛИТИКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS AND ANALYSIS</subject></subj-group></article-categories><title-group><article-title>ГОРМОН ЛЕПТИН И ПРОБЛЕМЫ РЕПРОДУКЦИИ</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Передереева</surname><given-names>Е. В.</given-names></name></name-alternatives><email xlink:type="simple">LAN21@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лушникова</surname><given-names>А. А.</given-names></name></name-alternatives><bio xml:lang="ru"><p>лаборатория онкогеномики, тел.+7 (499) 323 58 66</p></bio><email xlink:type="simple">LAN21@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фрыкин</surname><given-names>А. Д.</given-names></name></name-alternatives><email xlink:type="simple">LAN21@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пароконная</surname><given-names>А. А.</given-names></name></name-alternatives><email xlink:type="simple">LAN21@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Российский онкологический научный центр им. Н.Н. Блохина РАМН, Москва</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>20</day><month>05</month><year>2015</year></pub-date><volume>2</volume><issue>1</issue><fpage>35</fpage><lpage>39</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Передереева Е.В., Лушникова А.А., Фрыкин А.Д., Пароконная А.А., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Передереева Е.В., Лушникова А.А., Фрыкин А.Д., Пароконная А.А.</copyright-holder><copyright-holder xml:lang="en">Передереева Е.В., Лушникова А.А., Фрыкин А.Д., Пароконная А.А.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.malignanttumors.org/jour/article/view/64">https://www.malignanttumors.org/jour/article/view/64</self-uri><abstract><p>В обзоре представлены результаты современных исследований роли гормона лептина в регуляции репродуктивных функций у человека.</p></abstract><kwd-group xml:lang="ru"><kwd>лептин</kwd><kwd>репродукция</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Iikuni N., Lam Q.L., Lu L. et al. Leptin and inflammation// Curr Immunol.Rev. 2008. – Vol. 4, N 2. – P. 70-79</mixed-citation><mixed-citation xml:lang="en">Iikuni N., Lam Q.L., Lu L. et al. Leptin and inflammation// Curr Immunol.Rev. 2008. – Vol. 4, N 2. – P. 70-79</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Cottrell E.C., Mercer J.C. Leptin receptors/ Handb Exp Pharmacol.- 2012 - Vol . 209.- P.3-21.</mixed-citation><mixed-citation xml:lang="en">Cottrell E.C., Mercer J.C. Leptin receptors/ Handb Exp Pharmacol.- 2012 - Vol . 209.- P.3-21.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Cervero A., Domínguez F., Horcajadas J.A. et al. The role of leptin in reproduction // Curr Opin Obstet Gynecol 2006 Vol 18, N 3, P.297-303</mixed-citation><mixed-citation xml:lang="en">Cervero A., Domínguez F., Horcajadas J.A. et al. The role of leptin in reproduction // Curr Opin Obstet Gynecol 2006 Vol 18, N 3, P.297-303</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Brannian J.D. Obesity and fertility // S D Med. – 2011. – Vol 64, N 7. – P. 251-254.</mixed-citation><mixed-citation xml:lang="en">Brannian J.D. Obesity and fertility // S D Med. – 2011. – Vol 64, N 7. – P. 251-254.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Brewer C.J., Balen A.H. The adverse effects of obesity on conception and implantation // Reproduction. - 2010. – Vol. 140, N 3. – P. 347-364.</mixed-citation><mixed-citation xml:lang="en">Brewer C.J., Balen A.H. The adverse effects of obesity on conception and implantation // Reproduction. - 2010. – Vol. 140, N 3. – P. 347-364.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Paz-Filho G., Lim E.L., Wong M.L., Licinio J. // Associations between adipokines and obesity-related cancer // Front Biosci. – 2011. - Vol.16. - P. 1634-1650.</mixed-citation><mixed-citation xml:lang="en">Paz-Filho G., Lim E.L., Wong M.L., Licinio J. // Associations between adipokines and obesity-related cancer // Front Biosci. – 2011. - Vol.16. - P. 1634-1650.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ghizzoni L., Barreca A., Mastorakos G. et al. Leptin inhibits steroid biosynthesis by human granulose-lutein cells // Horm Metab Res. - 2001. - Vol. 33, N 6. – P. 323-326.</mixed-citation><mixed-citation xml:lang="en">Ghizzoni L., Barreca A., Mastorakos G. et al. Leptin inhibits steroid biosynthesis by human granulose-lutein cells // Horm Metab Res. - 2001. - Vol. 33, N 6. – P. 323-326.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Moyniham A.T., Hehir M.P., Glavey S.V. et al. Inhibitory effect of leptin on human uterine contractility in vitro // Am J Obstet Gynecol. – 2006. – Vol. 2. – P.504-509</mixed-citation><mixed-citation xml:lang="en">Moyniham A.T., Hehir M.P., Glavey S.V. et al. Inhibitory effect of leptin on human uterine contractility in vitro // Am J Obstet Gynecol. – 2006. – Vol. 2. – P.504-509</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Gambino Y.P., Maymό J.L., Pérez Peréz A. et al. Elsevier Trophoblast Research Award Lecture: Molecular mechanisms underlying estrogen functions in trophoblastics cells – focus on leptin expression. Placenta. – 2011. – Dec., e. 23.</mixed-citation><mixed-citation xml:lang="en">Gambino Y.P., Maymό J.L., Pérez Peréz A. et al. Elsevier Trophoblast Research Award Lecture: Molecular mechanisms underlying estrogen functions in trophoblastics cells – focus on leptin expression. Placenta. – 2011. – Dec., e. 23.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Tamer Erel C., Senturk L.M. Thr impact of body mass index on assisted reproduction// Curr.Opin Obstet Gynecol . – 2009. – Vol. 21, N3. – P. 228-235.</mixed-citation><mixed-citation xml:lang="en">Tamer Erel C., Senturk L.M. Thr impact of body mass index on assisted reproduction// Curr.Opin Obstet Gynecol . – 2009. – Vol. 21, N3. – P. 228-235.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Wu M.H., Chuang P.C., Chen H.M. et al. Increased leptin expression in endometriosis cells is associated with endometrial stromal cell proliferation and leptin gene up-regulation // Mol Hum Reprod. – 2002. – Vol. 8, N 5. – P.456-464.</mixed-citation><mixed-citation xml:lang="en">Wu M.H., Chuang P.C., Chen H.M. et al. Increased leptin expression in endometriosis cells is associated with endometrial stromal cell proliferation and leptin gene up-regulation // Mol Hum Reprod. – 2002. – Vol. 8, N 5. – P.456-464.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Lima-Couy I., Cervero A., Bonilla-Musoles F. Et al. Endometrial leptin and leptin receptor expression in women with severe/moderate endometriosis // Mol Hum Reprod. – 2004. – Vol. 10, N 11. – P. 777-782.</mixed-citation><mixed-citation xml:lang="en">Lima-Couy I., Cervero A., Bonilla-Musoles F. Et al. Endometrial leptin and leptin receptor expression in women with severe/moderate endometriosis // Mol Hum Reprod. – 2004. – Vol. 10, N 11. – P. 777-782.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Hassan M.A., Killick S.R. Negative lifestyle is associated with a significant reduction in fecundity // Fertil Steril. – 2004. – Vol.81, N 2. P. 384-392.</mixed-citation><mixed-citation xml:lang="en">Hassan M.A., Killick S.R. Negative lifestyle is associated with a significant reduction in fecundity // Fertil Steril. – 2004. – Vol.81, N 2. P. 384-392.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Segal K., Landt M., Klein S. Relationships between insulin sensitivity and plasma leptin concentration in lean and obese men.// Diabetes. – 1996. – Vol. 45, N 7. – З. 988-991.</mixed-citation><mixed-citation xml:lang="en">Segal K., Landt M., Klein S. Relationships between insulin sensitivity and plasma leptin concentration in lean and obese men.// Diabetes. – 1996. – Vol. 45, N 7. – З. 988-991.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Beate K., Josef N., Nicolas de R., Wolfram K. Genetics of isolated hypogonadotropic hypogonadism: role of GnR receptor and other genes // Int.J.Endocrinol.-2012; 2012:147893</mixed-citation><mixed-citation xml:lang="en">Beate K., Josef N., Nicolas de R., Wolfram K. Genetics of isolated hypogonadotropic hypogonadism: role of GnR receptor and other genes // Int.J.Endocrinol.-2012; 2012:147893</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Fischer –Popovszky P., von Schnurben J., Moepps B. et al. A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting N cell responsiveness // J. Clin.Endocrinol. Metab. – 2010. – Vol.95, N 6. – P.2836-2840.</mixed-citation><mixed-citation xml:lang="en">Fischer –Popovszky P., von Schnurben J., Moepps B. et al. A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting N cell responsiveness // J. Clin.Endocrinol. Metab. – 2010. – Vol.95, N 6. – P.2836-2840.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Mazen I., El-Gamma M., Abdel-Hamid M. et al. Homozygoty for novel missense mutation in the leptin receptor gene (P316N) in two Egyptian cousins with severe early onset obesity // Mol Genet Metab. – 2011. – Vol. 102, N 4. – P. 461-464.</mixed-citation><mixed-citation xml:lang="en">Mazen I., El-Gamma M., Abdel-Hamid M. et al. Homozygoty for novel missense mutation in the leptin receptor gene (P316N) in two Egyptian cousins with severe early onset obesity // Mol Genet Metab. – 2011. – Vol. 102, N 4. – P. 461-464.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Abir R., Ao A., Jin S. Leptin and its receptors in human fetal and adult ovaries// Fertil Steril. – 2005. – Vol.84, N 6. – P. 1779-1782).</mixed-citation><mixed-citation xml:lang="en">Abir R., Ao A., Jin S. Leptin and its receptors in human fetal and adult ovaries// Fertil Steril. – 2005. – Vol.84, N 6. – P. 1779-1782).</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Pasquali R., Gambineri A. Metabolic effects of obesity on reproduction // Reprod Biomed Online. – 2006. – Vol. 12, N 5. – P. 542-551.</mixed-citation><mixed-citation xml:lang="en">Pasquali R., Gambineri A. Metabolic effects of obesity on reproduction // Reprod Biomed Online. – 2006. – Vol. 12, N 5. – P. 542-551.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Cirillo D., Rachiglio A.M., la Montagna R. et al. Leptin signaling in breast cancer: an overview // J.Cell Biochem. – 2008. – Vol. 105, N 4. – P. 956-964.</mixed-citation><mixed-citation xml:lang="en">Cirillo D., Rachiglio A.M., la Montagna R. et al. Leptin signaling in breast cancer: an overview // J.Cell Biochem. – 2008. – Vol. 105, N 4. – P. 956-964.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Han G., Wang L., Zhao R. et al. Leptin promotes human glioblastoma growth through activating signal transducers and activators of transcription 3 signalling// Brain Res bull. – 2011. - Nov.30.</mixed-citation><mixed-citation xml:lang="en">Han G., Wang L., Zhao R. et al. Leptin promotes human glioblastoma growth through activating signal transducers and activators of transcription 3 signalling// Brain Res bull. – 2011. - Nov.30.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Li Y., Geng J., Wang Y. et al. The role of leptin receptor gene polymorphism in determining the susceptibility and prognosis of NSCLC in Chinese patients // J.Cancer Res Clin Oncol. – 2011. – Nov.30.</mixed-citation><mixed-citation xml:lang="en">Li Y., Geng J., Wang Y. et al. The role of leptin receptor gene polymorphism in determining the susceptibility and prognosis of NSCLC in Chinese patients // J.Cancer Res Clin Oncol. – 2011. – Nov.30.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Liu C., Liu L. Polymorphisms in three obesity-related genes (LEP, LEPR, and PON1) and breast cancer risk: a meta-analysis // Tumor Biol. – 2011. – N 6. – P. 1233-1240.</mixed-citation><mixed-citation xml:lang="en">Liu C., Liu L. Polymorphisms in three obesity-related genes (LEP, LEPR, and PON1) and breast cancer risk: a meta-analysis // Tumor Biol. – 2011. – N 6. – P. 1233-1240.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Cleveland R.J., Gammon M.D., Long C.M. et al. Common genetic variations in the LEP and LEPR genes, obesity and breast cancer incidence and survival // Breast Cancer Res Treat. – 2010. . – Vol. 120, N 3. – P. 745-752.</mixed-citation><mixed-citation xml:lang="en">Cleveland R.J., Gammon M.D., Long C.M. et al. Common genetic variations in the LEP and LEPR genes, obesity and breast cancer incidence and survival // Breast Cancer Res Treat. – 2010. . – Vol. 120, N 3. – P. 745-752.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Snoussi K., Strosberg A.D., Bouaouina N. et al. Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma // BNC Cancer. – 2006. – Feb 20. – P. 6-38.</mixed-citation><mixed-citation xml:lang="en">Snoussi K., Strosberg A.D., Bouaouina N. et al. Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma // BNC Cancer. – 2006. – Feb 20. – P. 6-38.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Лушникова А.А., Передереева Е.В., Пароконная А.А. и др. Продукция лептина в опухолевой ткани и плазме крови при фиброаденоме и раке молочной железы. Молекулярн. Медицина. – 2011. – № 3. – С.36-40.</mixed-citation><mixed-citation xml:lang="en">Лушникова А.А., Передереева Е.В., Пароконная А.А. и др. Продукция лептина в опухолевой ткани и плазме крови при фиброаденоме и раке молочной железы. Молекулярн. Медицина. – 2011. – № 3. – С.36-40.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Feldman D.E., Chen Ch., Punj V. et al. Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells // PNAS. – 2011. – Dec.29.</mixed-citation><mixed-citation xml:lang="en">Feldman D.E., Chen Ch., Punj V. et al. Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells // PNAS. – 2011. – Dec.29.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Guo S., Liu M., Wang G. et al. Oncogenic role and the therapeutic target of leptin signaling in breast cancer and cancer stem cells// Biochim Biophys Acta. – 2012. – Jan 24.</mixed-citation><mixed-citation xml:lang="en">Guo S., Liu M., Wang G. et al. Oncogenic role and the therapeutic target of leptin signaling in breast cancer and cancer stem cells// Biochim Biophys Acta. – 2012. – Jan 24.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Jahan S., Bibi R., Ahmed S., Kafeel S. Leptin levels in infertile males // J.Coll Physicians Surg Pak. - 2011. – Vol. 21, N 7. – P. 393-397</mixed-citation><mixed-citation xml:lang="en">Jahan S., Bibi R., Ahmed S., Kafeel S. Leptin levels in infertile males // J.Coll Physicians Surg Pak. - 2011. – Vol. 21, N 7. – P. 393-397</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Teerds K.J., de Rooij D.G., Keijer J. Functional relationships between obesity and male reproduction: from humans to animal models // Hum Reprod Update. – 2011. – Vol. 17, N 5. – P. 667-683.</mixed-citation><mixed-citation xml:lang="en">Teerds K.J., de Rooij D.G., Keijer J. Functional relationships between obesity and male reproduction: from humans to animal models // Hum Reprod Update. – 2011. – Vol. 17, N 5. – P. 667-683.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
