tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2019-9-1-53-58tumors-617Research ArticleКЛИНИЧЕСКИЕ СЛУЧАИCLINICAL NOTESАвелумаб в лечении пациентов с карциномой меркеля: первые результаты программы раннего доступа в РоссииAvelumab in the treatment of patients with merkel cell carcinoma: initial results of early access program in RussiaОрловаК. В.OrlovaK. V.

Кристина В. Орлова, кандидат медицинских наук, старший научный сотрудник отделения биотерапии 

Москва

Kristina V. Orlova, MD, PhD, Senior Researcher, Department of Biotherapy

Moscow

krisman03@gmail.comНазароваВ. В.NazarovaV. V.

Валерия В. Назарова, врач-онколог отделения биотерапии 

Москва

Valeria V. Nazarova, Oncologist, Department of Biotherapy

Moscow

jezerovel@gmail.comПетенкоН. Н.PetenkoN. N.

Наталия Н. Петенко, кандидат медицинских наук, врач-онколог отделения биотерапии

 

Москва

Nataliya N. Petenko, MD, PhD, Department of Biotherapy

Moscow

n.petenko@gmail.comДемидовЛ. В.DemidovL. V.

Лев В. Демидов, доктор медицинских наук, профессор, заведующий отделения биотерапии

Москва

 

Lev V. Demidov, MD, PhD, DSc, Professor, Head of the Department of Biotherapy

Moscow

demidov.lev@gmail.comФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииРоссияN. N. Blokhin Russian Cancer Research CenterRussian Federation201910042019915358Copyright © Орлова К.В., Назарова В.В., Петенко Н.Н., Демидов Л.В., 20192019Орлова К.В., Назарова В.В., Петенко Н.Н., Демидов Л.В.Orlova K.V., Nazarova V.V., Petenko N.N., Demidov L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/617

Карцинома Меркеля (КМ) — это редкая и агрессивная опухоль кожи с ограниченными возможностями терапии на поздних стадиях, когда летальность, обусловленная заболеванием, достигает 46%. Ранее было показано, что КМ является иммуногенной опухолью, поэтому появление ингибиторов контрольных точек иммунного ответа изменило лечебные принципы больных распространенной КМ. В данной статье мы представляем первые результаты применения в России анти-PD–L1 антитела авелумаб в лечении больных метастатической и/или местно-распространенной КМ в рамках программы раннего доступа.

Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer with limited treatment options in later stages, when the mortality rate due to the disease is as high as 46 %. It has been demonstrated earlier that MCC is an immunogenic tumor, therefore the emergence of immune checkpoint inhibitors has changed the treatment principles for patients with advanced MCC. In this article, we present the initial results of the use of avelumab, an anti‑PD–L1 antibody, in the treatment of patients with metastatic and/or locally advanced MCC as part of the early access program in Russia.

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The authors declare that there are no conflicts of interest present.