tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2019-9-2-5-11tumors-596Research ArticleОБЗОРЫ И АНАЛИТИКАREVIEWS AND ANALYSISРоль кишечной микробиоты при иммунотерапии рака толстой кишкиThe Role of the Intestinal Microbiome in the Immunotherapy of Colon CancerХакимоваГ. Г.KhakimovaG. G.

Гулноз Г. Хакимова - аспирант отделения химиотерапии и комбинированного лечения злокачественных опухолей.

Москва

Gulnoz G. Khakimova, postgraduate student, Department of Chemotherapy and Combined Treatment of Malignant Tumors.

Moscow

hgg_doc@mail.ruТрякинА. А.TryakinA. A.

Алексей А. Трякин - доктор медицинских наук, старший научный сотрудник отделения клинической фармакологии и химиотерапии.

Alexey A. Tryakin - MD, PhD, DSc, Senior Researcher, Department of Clinical Pharmacology and Chemotherapy.

Moscow

ЗаботинаТ. Н.ZabotinaT. N.

Татьяна Н. Заботина - доктор биологических наук, заведующая централизованным клинико-лабораторным отделом.

Tatyana N. Zabotina - MD, DSC Biol, Head of Centralized Clinical and Laboratory Department.

Moscow

ЦукановА. С.TsukanovA. S.

Алексей С. Цуканов - доктор медицинских наук, заведующий кабинетом лабораторной генетики.

Alexey S. Tsukanov - MD, PhD, DSc, Head of Laboratory Genetics Department.

Moscow

АлиевВ. А.AlievV. A.

Вячеслав А. Алиев - доктор медицинских наук, старший научный сотрудник отделения колопроктологии.

Москва

Vyacheslav A. Aliev - MD, PhD, DSc, Senior Researcher, Department of Coloproctology.

Moscow

ГуторовС. Л.GutorovS. L.

Сергей Л. Гуторов - доктор медицинских наук, ведущий научный сотрудник отделения химиотерапии и комбинированного лечения злокачественных опухолей

Sergey L. Gutorov - MD, PhD, DSc, Leading Researcher, Department of Chemotherapy and Combined Treatment of Malignant Tumors.

Moscow

ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииРоссияN.N. Blokhin National Medical Research Center of OncologyRussian FederationФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииРоссияN.N. Blokhin National Medical Research Center of OncologyRussian FederationГосударственный Научный Центр КолопроктологииРоссияState Scientific Center of ColoproctologyRussian Federation20192606201992511Copyright © Хакимова Г.Г., Трякин А.А., Заботина Т.Н., Цуканов А.С., Алиев В.А., Гуторов С.Л., 20192019Хакимова Г.Г., Трякин А.А., Заботина Т.Н., Цуканов А.С., Алиев В.А., Гуторов С.Л.Khakimova G.G., Tryakin A.A., Zabotina T.N., Tsukanov A.S., Aliev V.A., Gutorov S.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/596

Считается, что генетические факторы, дисфункция иммунной системы, хроническое воспаление и дисбиоз кишечной микробиоты (КМ) являются частью патогенеза колоректального рака (КРР). Положительная роль регуляции КМ при лечении воспалительных заболеваний кишечника определяется снижением роста патогенных бактерий и увеличением продукции противовоспалительных факторов. На сегодняшний день, современные данные свидетельствуют о том, что Ш дисрегулирует иммунный ответ против опухоли в ее микроокружении, тем самым замедляя либо ускоряя эффективность противоопухолевой терапии. В клинических исследованиях сообщается о преимуществах терапии КРР с учетом состава Ш, в отношении улучшения иммунного гомеостаза кишечника, функции эпителиального барьера и качества жизни. Между тем, специфическая сигнатура КМ может модулировать чувствительность к химиои /или лучевой терапии и прогноз пациентов раком толстой кишки. В данной статье, мы представили общие проблемы терапии КРР, основанной на данных по КМ в сочетании с иммунотерапией, а также описали направления будущих перспектив.

Genetic factors, immune dysfunction, chronic inflammation, and dysbiosis of the intestinal microbiome (IM) are believed to participate in the pathogenesis of colorectal cancer (CRC). The positive role of IM regulation in the treatment of inflammatory bowel disorders is determined by a reduction in the growth of pathogenic bacteria and an increase in the production of anti-inflammatory factors. Currently, the available data suggests that the IM dysregulates the immune response against the tumor in its microenvironment, thus either slowing down or accelerating the efficacy of antitumor therapy. Clinical studies have reported benefits of CRC therapy selected based on IM in improving immune intestinal homeostasis, epithelial barrier functions, and quality of life. Moreover, the specific IM signature may modulate the sensitivity to chemoand/ or radiotherapy, as well as the prognosis in patients with colorectal cancer. In this article, we presented the general challenges of the CRC therapy based on IM data in combination with immunotherapy, and described the future prospects of this approach.

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The authors declare that there are no conflicts of interest present.