References

tumors

Malignant tumours

2224-50572587-6813

Rosoncoweb

tumors-551

Research Article

ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ

ORIGINAL REPORTS

Морфологические особенности BRCA1‑ассоциированных опухолей

Иванцов

А. О.

Насыров

Р. А.

Имянитов

E. H.

Соколенко

А. П.

ФГБУ «Научно-исследовательский институт онкологии имени Н. Н. Петрова» Министерства здравоохранения РФ; ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Министерства здравоохранения РФ.Russian Federation

2018

12112018

83s19095

2018

Иванцов А.О., Насыров Р.А., Имянитов E.H., Соколенко А.П.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.malignanttumors.org/jour/article/view/551

BRCA1‑ассоциированные новообразования представляют собой большую гетерогенную группу опухолей с различным фенотипом, клинической картиной и прогнозом. Наличие мутации BRCA1 позволяет использовать современные эффективные стратегии лекарственной терапии опухолей с использованием PARP-ингибиторов для достижения наилучших результатов лечения. Новообразования молочной железы и яичника у носителей мутаций BRCA1 возникают значительно чаще, чем опухоли иных локализаций. BRCA1‑ассоциированные карциномы имеют определенные морфологические особенности, которые позволяют рекомендовать пациентам проведение молекулярно-генетического исследования.

BRCA1мутацияракморфологические особенности

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The authors declare that there are no conflicts of interest present.