tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncowebtumors-548Research ArticleОБЗОРЫ И АНАЛИТИКАREVIEWS AND ANALYSISВопросы репродукции и BRCA-ассоциированный рак молочной железы (обзор)ПароконнаяА. А.ANAPAR1@yandex.ruФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Министерства здравоохранения РФ.Russian Federation20181211201883s17075Copyright © Пароконная А.А., 20182018Пароконная А.А.Пароконная А.А.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/548

Вопросы сохранения фертильности и безопасность последующей беременности приобретают в последнее время особую значимость, составляя неотъемлемую часть реабилитационных мероприятий у молодых пациенток с диагностированным раком молочной железы (РМЖ). В этой связи немаловажным является учет генетических особенностей для планирования семьи и деторождения в группе молодых пациенток. Однако не существует единой концепции, позволяющей однозначно ответить на вопросы: как беременность и роды влияют на риск развития РМЖ у носительниц мутаций генов BRCA1 / 2; действуют ли такие «репродуктивные факторы», как возраст первых родов, длительность лактации, возраст наступления менархе, в качестве модификаторов риска в группе носителей мутаций BRCA1 / 2; каков исходный репродуктивный потенциал пациенток из этой группы; безопасна ли последующая беременность и влияет ли она на прогноз заболевания при BRCA-ассоциированном раке.

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The authors declare that there are no conflicts of interest present.