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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">tumors</journal-id><journal-title-group><journal-title xml:lang="ru">Malignant tumours</journal-title><trans-title-group xml:lang="en"><trans-title>Malignant tumours</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2224-5057</issn><issn pub-type="epub">2587-6813</issn><publisher><publisher-name>Rosoncoweb</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">tumors-545</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL REPORTS</subject></subj-group></article-categories><title-group><article-title>Расчет эффективности неоадъювантной химиотерапии у больных с диагнозом трижды негативный рак молочной железы</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Орлов</surname><given-names>А. E.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козлов</surname><given-names>С. В.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Савельев</surname><given-names>В. H.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ткачев</surname><given-names>М. В.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Борисов</surname><given-names>А. П.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГБУЗ «Самарский областной клинический онкологический диспансер».</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>11</day><month>11</month><year>2018</year></pub-date><volume>8</volume><issue>3s1</issue><fpage>47</fpage><lpage>49</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Орлов А.E., Козлов С.В., Савельев В.H., Ткачев М.В., Борисов А.П., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Орлов А.E., Козлов С.В., Савельев В.H., Ткачев М.В., Борисов А.П.</copyright-holder><copyright-holder xml:lang="en">Орлов А.E., Козлов С.В., Савельев В.H., Ткачев М.В., Борисов А.П.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.malignanttumors.org/jour/article/view/545">https://www.malignanttumors.org/jour/article/view/545</self-uri><abstract><p>В работе описан принцип создания математической модели и программы для ЭВМ по расчету эффективности неоадъювантной химиотерапии с включением антракциклинов у больных с диагнозом трижды негативный рак молочной железы. Данное исследование проведено в Самарском областном клиническом онкологическом диспансере на основе статистической обработки результатов лечения 98 пациентов. Предложенная математическая модель и программа для ЭВМ (Свидетельство о государственной регистрации программ для ЭВМ № 2017660720 от 25.09.2017) позволяет с высокими показателями точности, чувствительности и специфичности определить эффективность химиотерапии, что возможно использовать для выработки схемы лечения больных с диагнозом трижды негативный рак молочной железы.</p></abstract><kwd-group xml:lang="ru"><kwd>рак молочной железы</kwd><kwd>химиотерапия</kwd><kwd>трижды негативный рак</kwd><kwd>математическая модель</kwd><kwd>программа для ЭВМ</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Giladi A.M., Chung K.C., Aliu O. 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