tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2015-1-42-48tumors-53Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL REPORTSСТАБИЛЬНЫЙ КАСТРАЦИОННЫЙ УРОВЕНЬ ТЕСТОСТЕРОНА ПРИ АНДРОГЕННОЙ ДЕПРИВАЦИИ КАК ФАКТОР ПРОГНОЗА ОПТИМАЛЬНОГО КЛИНИЧЕСКОГО КОНТРОЛЯ У БОЛЬНЫХ РАКОМ ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫStable castration level of testosterone in androgendeprivation therapy for clear cell renal cell carcinomaГРИЦКЕВИЧА. А.GritskevichA. A.

к. м.н., старший научный сотрудник отделения урологии,

г.Москва

Moscow

grekaa@mail.ruМИШУГИНС. В.MishuginS. V.

к. м.н., заведующий отделением онкоурологии

Moscow

mordovin-posylka@mail.ruТЕПЛОВА. А.TeplovA. A.

д. м.н., профессор, заведующий отделения урологии,

г. Москва

Moscow

a.a.teplov@yandex.ruРУСАКОВИ. Г.RusakovI. G.

д. м. н., профессор, заместитель главного врача по онкологии,

г. Москва

Moscow

igorrusakov@mail.ruИнститут хирургии им. А. В. ВишневскогоРоссияInstitute of Surgery A.V. VishnevskyRussian FederationГородская клиническая больница № 57РоссияMoscow City Clinical Hospital № 57Russian FederationГБУЗ ГКБ №57РоссияMoscow City Clinical Hospital № 57Russian Federation201520052015014653Copyright © ГРИЦКЕВИЧ А.А., МИШУГИН С.В., ТЕПЛОВ А.А., РУСАКОВ И.Г., 20152015ГРИЦКЕВИЧ А.А., МИШУГИН С.В., ТЕПЛОВ А.А., РУСАКОВ И.Г.Gritskevich A.A., Mishugin S.V., Teplov A.A., Rusakov I.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/53

Одной из важнейших стратегий лечения рака предстательной железы является достижение и поддержание эффективного подавления уровня тестостерона у мужчин, получающих андрогенную депривацию. Исторически уровень тестостерона ниже 50 нг/дл расценивался как кастрационный. Текущие данные показывают, что в попытке максимизировать терапевтический результат новой целью для любой хирургической или химической кастрации является уровень тестостерона ниже чем 20 нг/дл. Эффект «вспышки», обусловленный введением аналога лютеинизирующего рилизинг-гормона, может вызвать увеличение уровня тестостерона, иногда до некастрационных значений. Изучение андрогенной аблации заключается в выявлении тех агентов, при помощи которых достигаются и поддерживаются какие возможно самые низкие уровни тестостерона.

One of the most important strategies for treating prostate cancer is to achieve and maintain effective suppression of testosterone levels in men receiving androgen deprivation. Historically, testosterone levels below 50 ng/dl was regarded as castration level. Current data indicate that in an attempt to maximize the therapeutic result of a new target for any surgical or chemical castration is a testosterone level below 20 ng/dl. The phenomenon of flash testosterone and exacerbation of chronic conditions by introducing an analog of luteinizing hormone releasing hormone can cause testosterone levels to rise periodically, sometimes up to a non-castration levels. The study of androgen ablation is to identify those agents with which achieved and maintained lowest levels of testosterone.

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The authors declare that there are no conflicts of interest present.