tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2018-8-2-50-59tumors-516Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL REPORTSВЫБОР ПОСЛЕДОВАТЕЛЬНОСТИ КОМБИНАЦИЙ ХИМИОПРЕПАРАТОВ И МОНОКЛОНАЛЬНЫХ АНТИТЕЛ В ЛЕЧЕНИИ БОЛЬНЫХ МЕТАСТАТИЧЕСКИМ РАКОМ ТОЛСТОЙ КИШКИOPTIMAL SEQUENCES AND COMBINATION OF CHEMOTHERAPY AND MONOCLONAL ANTIBODIES IN THE TREATMENT OF PATIENTS WITH METASTATIC COLORECTAL CANCERФедянинМ. Ю.FedyaninM. Yu.

Михаил Ю. Федянин - кандидат медицинских наук, старший научный сотрудник отделения клинической фармакологии и химиотерапии.

Москва

Mikhail Yu. Fedyanin, MD, PhD Med, Senior Researcher, Department of Clinical Pharmacology and Chemotherapy.

Moscow

fedianinmu@mail.ruТюляндинС. А.TjulandinS. A.

Сергей А. Тюляндин, доктор медицинских наук, профессор, зав. отделением клинической фармакологии и химиотерапии.

Москва

Sergey A. Tjulandin, MD, DSc Med, Professor, Head of the Department of Clinical Pharmacology and Chemotherapy.

Moscow

stjulandin@gmail.comФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Министерства здравоохранения РФРоссияN.N. Blokhin Russian Cancer Research CenterRussian Federation201812072018825059Copyright © Федянин М.Ю., Тюляндин С.А., 20182018Федянин М.Ю., Тюляндин С.А.Fedyanin M.Y., Tjulandin S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/516

В настоящем обзоре литературы проанализированы работы, посвящённые выбору терапии первой и последующих линий лечения у больных метастатическим раком толстой кишки. Обсуждены данные по результатам сочетания таргетных моноклональных антител с различными режимами химиотерапии. Освещены современные исследования по тактике выбора последовательности таргетной терапии у больных с метастатическим заболеванием. Также рассмотрены вопросы влияния различных факторов на эффективность терапии теми или иными препаратами и их места в выборе терапии при раке толстой кишки.

In this review we analyzed results of studies concerning the choice of first and subsequent lines of therapy in patients with metastatic colon cancer. We discussed data of various combinations of monoclonal antibodies with different chemotherapeutic regimens. Also we discussed modern preclinical and clinical trials concerning strategy of choice of targeted therapy sequence in patients with metastatic disease. We considered the impact of various molecular and clinical factors on the effectiveness of drugs and determined their application for therapy choice for colon cancer.

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The authors declare that there are no conflicts of interest present.