tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2013-3-42-50tumors-51Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL REPORTSОТЕЧЕСТВЕННЫЙ ОПЫТ ПРОФИЛАКТИКИ И ЛЕЧЕНИЯ ПРОЯВЛЕНИЙ КОЖНОЙ ТОКСИЧНОСТИ У ПАЦИЕНТОВ МКРР, ПОЛУЧАЮЩИХ ИНГИБИТОРЫ EGFR, НА ПРИМЕРЕ ПРЕПАРАТА ПАНИТУМУМАБDomestic experience of prevention and treatment of skin toxicity in patients with metastatic colorectal cancer receiving inhibitors of EGFR: the example of using of panitumumabВарламоваС. Е.VarlamovaS. E.ОрловаЕ. В.OrlovaE. V.ПтушкинВ. В.PtushkinV. V.БолотинаЛ. В.BolotinaL. V.АнтимоникН. Ю.AntimonikN. Yu.ВладимироваЛ. Ю.VladimirovaL. Yu.МакеевЮ. М.MakeevYu. M.КозловаН. М.KozlovaN. M.БердовБ. А.BerdovB. A.ФеоктистоваП. С.FeoktistovaP. S.ФГБУ ГНЦ ФМБЦ им. А. И. Бурназяна ФМБА России, г. МоскваRussian FederationГБОУ ВПО Первый МГМУ им. И. М. Сеченова Минздрава России, г. Москва.Russian FederationФГБУ «ФНКЦ ДГОИ им. Дмитрия Рогачева» Минздрава России, г. МоскваRussian FederationМосковский научно-исследовательский онкологический институт им. П. А. Герцена, г. МоскваRussian Federation«Городской клинический онкологический диспансер», г. Санкт-ПетербургRussian FederationФГБУ «Ростовский научно-исследовательский онкологический институт» Минздрава России, г. Ростов-на-ДонуRussian FederationГБУЗ «Московский областной онкологический диспансер», г. БалашихаRussian FederationФГБУ «Медицинский радиологический научный центр» Минздрава России, г. Обнинск.Russian FederationУчреждение ХМАО-ЮГРЫ «Нижневартовский онкологический диспансер», г. НижневартовскRussian Federation201320052015034250Copyright © Варламова С.Е., Орлова Е.В., Птушкин В.В., Болотина Л.В., Антимоник Н.Ю., Владимирова Л.Ю., Макеев Ю.М., Козлова Н.М., Бердов Б.А., Феоктистова П.С., 20152015Варламова С.Е., Орлова Е.В., Птушкин В.В., Болотина Л.В., Антимоник Н.Ю., Владимирова Л.Ю., Макеев Ю.М., Козлова Н.М., Бердов Б.А., Феоктистова П.С.Varlamova S.E., Orlova E.V., Ptushkin V.V., Bolotina L.V., Antimonik N.Y., Vladimirova L.Y., Makeev Y.M., Kozlova N.M., Berdov B.A., Feoktistova P.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/51

Освещены результаты первого отечественного опыта коррекции кожной токсичности у пациентов мКРР, получающих ингибиторы EGRF, на примере препарата Панитумумаб. Сбор и оценка данных произведены в рамках проекта рабочей группы по поддерживающей терапии Профессионального Общества онкологов-химиотерапевтов (RUSSCO) по разработке рекомендаций для профилактики и лечения дерматологической токсичности у пациентов, получающих ингибиторы EGFR. В проекте принимали участие 10 центров РФ. У 58 пациентов, получавших Панитумумаб, оценивалась эффективность профилактической медикаментозной и симптоматической терапии клинических проявлений дерматологической токсичности доступными средствами. Полученные результаты подтверждают эффективность профилактической терапии. Разработаны оптимальные схемы коррекции различных проявлений кожной токсичности в зависимости от клинических проявлений и степени тяжести.

The results of the first national experience of skin toxicity correction in patients with metastatic colorectal cancer (mCRC) receiving EGRF-inhibitors shown on the example of using of Panitumumab. The collection and evaluation of the data were produced in the framework of the project of the working group on maintenance therapy of Russian society of clinical oncologists and chemotherapeutists (RUSSCO) to develop recommendations for the prevention and treatment of dermatological toxicity in patients receiving EGFR-inhibitors. The project involved 10 centers in Russia.  In 58 patients receiving Panitumumab, the efficacy of prophylactic medication and symptomatic treatment of clinical manifestations of dermatological toxicity using available remedies was evaluated. The results confirm the effectiveness of preventive therapy. Optimal correction schemes of various manifestations of dermal toxicity were developed depending on the clinical manifestations and severity.

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The authors declare that there are no conflicts of interest present.