tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2018-8-1-55-60tumors-488Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL REPORTSИксабепилон в современной терапии резистентного рака молочной железыIxabepilone in modern therapy of resistant breast cancerРумянцевА. А.RumyantsevA. A.

аспирант, отделение клинической фармакологии и химиотерапии

MD, PhD student, Department of Clinical Pharmacology and Chemotherapy

alexeymma@gmail.comИвановВ. Г.IvanovV. G.

к. м. н., научный сотрудник, отделение опухолей молочной железы

MD, PhD, Researcher of the Department of Breast Tumors

doctorivanov@msn.comФГБУ «НМИЦ онкологии им. Н. Н. Блохина» Министерства здравоохранения РФРоссияN. N. Blokhin Russian Cancer Research CenterRussian FederationФГБУ «НИИ онкологии им. Н.Н. Петрова» Министерства здравоохранения РФРоссияN.N. Petrov Research Institute of OncologyRussian Federation201809052018815560Copyright © Румянцев А.А., Иванов В.Г., 20182018Румянцев А.А., Иванов В.Г.Rumyantsev A.A., Ivanov V.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/488

Развитие лекарственной резистентности после стандартных схем лечения РМЖ является серьезной проблемой. Поэтому поиск препаратов, которые были бы эффективны после использования золотого стандарта (антрациклины и таксаны) в адъювантном и неоадъювантной режимах, а также при лечении метастатического рака молочной железы чрезвычайно актуален.

В обзорной статье рассматриваются вопросы использования аналога эпотилона-В иксабепилона как в монорежиме, так и в комбинации с другими препаратами: химиогормонотерапией после использования антрациклинов и таксанов. Уделено внимание эффективности использования иксабепилона, развитию осложнений, спектру безопасности препарата, а также эффективности лечения в зависимости от различных видов РМЖ; обсуждаются вопросы развития химиорезистентности.

Ixabepilone is an epothilone analog, active as a cytotoxic agent due to its ability to stabilize microtubules of tumor cells. Currently ixabepiloneis approved for treatment of metastatic breast cancer in patients previously treated with taxanes and anthracyclines. In this article we analyzed existing data about its efficacy in preoperative and adjuvant treatment settings as well as in systemic therapy of metastatic breast cancer. We discussed a role of ixabepilone in contemporary treatment of this disease.

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The authors declare that there are no conflicts of interest present.