tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2017-2-54-61tumors-343Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL REPORTSХимиотерапия в комбинации с Бевацизумабом при раке молочной железы. Результаты наблюдательного исследования в ежедневной клинической практикеChemotherapy in combination with bevacizumab in breast cancer. Results of the observational study in daily clinical practiceКоваленкоЕ. И.KovalenkoE. I.

к.м.н., научный сотрудник отделения амбулаторной химиотерапии (дневной стационар)

phD, research associate, Out-patient Chemotherapy Department

eikovalenko@mail.ruОсмановаЛ. И.OsmanovaL. I.

к.м.н., врач отделения амбулаторной химиотерапии (дневной стационар)

phD, Out-patient Chemotherapy Department

osmanova@list.ruКононенкоИ. Б.KononenkoI. B.

к.м.н., врач отделения амбулаторной химиотерапии (дневной стационар)

phD, Out-patient Chemotherapy Department

inessa.kononenko@mail.ruАбдуллаеваЕ. Ф.AbdullaevaE. F.

врач отделения амбулаторной химиотерапии (дневной стационар)

Out-patient Chemotherapy Department

lena.satirova@mail.ruАртамоноваЕ. В.ArtamonovaE. V.

д.м.н., ведущий научный сотрудник отделения амбулаторной химиотерапии (дневной стационар)

phD, leading research associate, Out-patient Chemotherapy Department

artamonovae@mail.ruМанзюкЛ. В.ManzyukL. V.

д.м.н., профессор, ведущий научный сотрудник отделения амбулаторной химиотерапии (дневной стационар)

phD, Professor, leading research associate, Out-patient Chemotherapy Department

L.Manzyuk@gmail.comФГБУ «РОНЦ им. Н. Н. Блохина», МоскваРоссияN. N. Blokhin Russian Cancer Research Center, MoscowRussian Federation201720072017025461Copyright © Коваленко Е.И., Османова Л.И., Кононенко И.Б., Абдуллаева Е.Ф., Артамонова Е.В., Манзюк Л.В., 20172017Коваленко Е.И., Османова Л.И., Кононенко И.Б., Абдуллаева Е.Ф., Артамонова Е.В., Манзюк Л.В.Kovalenko E.I., Osmanova L.I., Kononenko I.B., Abdullaeva E.F., Artamonova E.V., Manzyuk L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/343

Бевацизумаб (Авастин) в комбинации с химиотерапией (ХТ) 1–2-й линий при метастатическом раке молочной железы (мРМЖ) в рандомизированных исследованиях III фазы не продемонстрировал увеличения общей выживаемости (ОВ) при значимом повышении частоты объективного ответа и выживаемости без прогрессирования (ВБП). Тем не менее в мире продолжаются наблюдательные исследования в ежедневной клинической практике по применению Бевацизумаба при РМЖ. Приводятся результаты собственного наблюдательного исследования, целью которого является оценка переносимости и эффективности Бевацизумаба в комбинации с ХТ у больных HER/2-негативным диссеминированным и местно-распростра- ненным раком молочной железы. В исследование включено 34 больных РМЖ (6 – местно-распространенным, 28 – метаста- тическим) в возрасте от 29 до 66 лет (средний – 49,5 лет). Бевацизумаб вводили в дозе от 7,5 до 15 мг/кг 1 раз в 3 недели в комбинации с ХТ. Всего пациентки получили 294 дозы Бевацизумаба (медиана – 10). При местно-распространенном РМЖ всем больным выполнено радикальное оперативное вмешательство, полный патоморфоз отмечен в 33,3%. При мРМЖ объ- ективный ответ составил 46,4%, контроль роста опухоли – 89,3%, медиана ВБП – 10 месяцев. Характерные для Бевацизумаба нежелательные явления (гипертензия, протеинурия) были умеренно выражены и встречались соответственно в 14,7% и 5,9% случаев. У 1 (2,9%) больной лечение осложнилось тромбозом глубоких вен и ТЭЛА на фоне прогрессирования основного заболевания. Заключение. Бевацизумаб в комбинации с ХТ для лечения РМЖ позволяет достичь высоких показателей объективного эффекта и ВБП независимо от линии лечения. 

In metastatic breast cancer (MBC) the combination of Bevacizumab (Avastin) and chemotherapy (CT) failed to demonstrate an increase in overall survival with a significant improvement of the objective response rate and progression-free survival (PFS) in randomized trials of the 3d phase. Nevertheless, observational studies in the daily clinical practice for the use of Bevacizumab in MBC continue in the world. We present the results of our own observational study, which goal is to assess the efficacy and tolerability of Bevacizumab in combination with CT in patients with HER/2-negative metastatic and locally advanced breast cancer. The study included 34 patients with breast cancer (6-locally advanced, 28-metastatic) at the age of 29 to 66 years (mean – 49.5). Bevacizumab was administered at a dose of 7.5 to 15 mg/kg every 3 weeks in combination with CT. In total, the patients received 294 doses of Bevacizumab (median – 10). All patients with locally advanced breast cancer were operated on after the treatment completion, a pathologic complete response was registered in 33.3%. In MBC, the objective response was registered in 46,4%, tumor growth control in 89.3%, median PFS – 10 months. Typical for Bevacizumab adverse events, such as hypertension, proteinuria, were moderate and were met respectively in 14.7% and in 5.9% cases. In 1 (2.9%) patient the treatment was complicated by deep vein thrombosis and PE due to disease progression. Conclusion. Bevacizumab in combination with CT in breast cancer treatment can achieve high rates of objective response and PFS independent of the treatment line

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The authors declare that there are no conflicts of interest present.