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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">tumors</journal-id><journal-title-group><journal-title xml:lang="ru">Malignant tumours</journal-title><trans-title-group xml:lang="en"><trans-title>Malignant tumours</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2224-5057</issn><issn pub-type="epub">2587-6813</issn><publisher><publisher-name>Rosoncoweb</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18027/2224-5057-2017-2-33-39</article-id><article-id custom-type="elpub" pub-id-type="custom">tumors-340</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL REPORTS</subject></subj-group></article-categories><title-group><article-title>Современная тактика лечения злокачественных глиом головного мозга и случай полного ответа опухоли на фоне длительного приема бевацизумаба</article-title><trans-title-group xml:lang="en"><trans-title>Modern tactics of treatment of malignant glyom of the brain and the case of the complete answer of the tumor on the background of the long-term reception of bevacizumab</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Муфазалов</surname><given-names>Ф. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Mufazalov</surname><given-names>F. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, заместитель главного врача</p></bio><bio xml:lang="en"><p>MD, Professor, Deputy Chief Physician</p></bio><email xlink:type="simple">prffm@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аббасова</surname><given-names>Р. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Abbasova</surname><given-names>R. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., заведующая радиологическим отделением № 2</p></bio><bio xml:lang="en"><p>PhD in Medical sciences, Head of the Radiological Department No. 2</p></bio><email xlink:type="simple">abbasovarr@onkorb.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Муфазалова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mufazalova</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор кафедры фармакологии № 1 с курсом клинической фармакологии</p></bio><bio xml:lang="en"><p>MD, Professor of the Department of Pharmacology No. 1 with the course of clinical pharmacology</p></bio><email xlink:type="simple">mufazalovanatalya@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гончарова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Goncharova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., врач-радиотерапевт радиологического отделения № 2</p></bio><bio xml:lang="en"><p>PhD in Medical sciences, radiotherapeutist of Department No. 2</p></bio><email xlink:type="simple">olvlgo79@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сафина</surname><given-names>Л. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Safina</surname><given-names>L. Kh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-радиотерапевт радиологического отделения № 2</p></bio><bio xml:lang="en"><p>radiotherapeutist of Department No. 2</p></bio><email xlink:type="simple">safina.oncotrial@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Муфазалова</surname><given-names>Л. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Mufazalova</surname><given-names>L. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., врач-радиотерапевт радиологического отделения № 2</p></bio><bio xml:lang="en"><p>PhD in Medical sciences, radiotherapeutist of Department No. 2</p></bio><email xlink:type="simple">lya-mufazalova@ya.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГУЗ «Республиканский клинический онкологический диспансер», Уфа</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Republican Clinical Oncology Center, Ufa</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Башкирский государственный медицинский университет», Уфа</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Bashkirian State Medical University, Ufa</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>20</day><month>07</month><year>2017</year></pub-date><volume>0</volume><issue>2</issue><fpage>33</fpage><lpage>39</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Муфазалов Ф.Ф., Аббасова Р.Р., Муфазалова Н.А., Гончарова О.В., Сафина Л.Х., Муфазалова Л.Ф., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Муфазалов Ф.Ф., Аббасова Р.Р., Муфазалова Н.А., Гончарова О.В., Сафина Л.Х., Муфазалова Л.Ф.</copyright-holder><copyright-holder xml:lang="en">Mufazalov F.F., Abbasova R.R., Mufazalova N.A., Goncharova O.V., Safina L.K., Mufazalova L.F.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.malignanttumors.org/jour/article/view/340">https://www.malignanttumors.org/jour/article/view/340</self-uri><abstract><p>Глиомы являются широко распространенными первичными опухолями головного мозга у взрослых. При этом глиомы высокой степени анаплазии характеризуются неутешительным прогнозом, несмотря на современные подходы к лечению. В связи с этим безусловный интерес представляют случаи длительного безрецидивного течения заболевания, применяемые схемы лечения и контроля над глиомами высокой степени анаплазии. Исключительный интерес представляет препарат бевацизумаб, который в нашей клинической практике позволил обеспечить пациенту безрецидивный период при глиоме высокой степени злокачественности с 2012 года по настоящее время. </p></abstract><trans-abstract xml:lang="en"><p>Gliomas are common primary brain tumors in adults. This high degree of glioma malignancy is characterized by a disappointing outlook, despite the modern approaches to treatment. Therefore cases of prolonged relapse-free period of the disease, as well as treatment regimen and control regimen concerning gliomas with high degree of anaplasia are of exceptional interest. Even more exceptionally interesting is the drug bevacizumab, which in our clinical practice allowed to provide the patient with the diseasefree high-grade glioma from 2012 year to the present. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>анапластическая астроцитома</kwd><kwd>глиомы</kwd><kwd>бевацизумаб</kwd></kwd-group><kwd-group xml:lang="en"><kwd>anaplastic astrocytoma</kwd><kwd>glioma</kwd><kwd>bevacizumab</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Brierley B.B. Fighting tumour with humour, The lancet Oncology, 2015, Vol. 16, No. 8, pp. 895–896.</mixed-citation><mixed-citation xml:lang="en">Brierley B.B. Fighting tumour with humour, The lancet Oncology, 2015, Vol. 16, No. 8, pp. 895–896.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Huang W. J., Chen W.W., Zhang X. 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