tumorsMalignant tumoursMalignant tumours2224-50572587-6813Rosoncoweb10.18027/2224-5057-2017-1-61-66tumors-329Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL REPORTSЛимфоидная инфильтрация как предиктор эффективности иммунотерапии меланомыLymphoid infiltration as a predictor of successful immunotherapy with melanomaТИТОВК. С.TITOVK. S.

д. м.н., заведующий онкохирургическим отделением опухолей кожи и мягких тканей, доцент кафедры онкологии и лучевой терапии лечебного факультета

MD, RhD, DSc, head of the Оnсоsurgery Department tumors of skin and soft fabrics, asistant professor of the Department of Oncology and Radiation Therapy

ks-titov@mail.ruЧИКИЛЕВАИ. О.CHIKILEVAO. I.

к. б.н., научный сотрудник лаборатории клеточного иммунитета НИИ Экспериментальной диагностики и терапии опухолей

MD, RhD, researcher of laboratory of cellular immunity

irinatchikileva@mail.ruКИСЕЛЕВСКИЙМ. В.KISELEVSKIYM. V.

д. м.н., профессор, заслуженный деятель науки РФ, заведующий лабораторией клеточного иммунитета НИИ Экспериментальной диагностики и терапии опухолей

MD, RhD, DSc, professor, head of the laboratory of cellular immunity

kisele@inbox.ruКАЗАКОВА. М.KAZAKOVA. M.

студент 5 курса лечебного факультета

student

kazakovrgmu@gmail.comМосковский клинический научный центр Департамента здравоохранения, Российский национальный исследовательский медицинский университет им. Н. И. Пирогова Минздрава РФРоссияMoscow Clinical Research Centr,N. I. Pirogov Russian National Research Medical UniversityRussian FederationФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» Минздрава РФРоссияN. N. Вlokhin Russian Сancer Research CentreRussian FederationФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н. И. Пирогова» Минздрава РФРоссияN. I. Pirogov Russian National Research Medical University,Russian Federation201705072017016166Copyright © ТИТОВ К.С., ЧИКИЛЕВА И.О., КИСЕЛЕВСКИЙ М.В., КАЗАКОВ А.М., 20172017ТИТОВ К.С., ЧИКИЛЕВА И.О., КИСЕЛЕВСКИЙ М.В., КАЗАКОВ А.М.TITOV K.S., CHIKILEVA O.I., KISELEVSKIY M.V., KAZAKOV A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.malignanttumors.org/jour/article/view/329

Меланома кожи составляет 1–4% от всех онкологических заболеваний. Среди всех злокачественных опухолей кожи меланома занимает особое место, на ее долю приходится около 4% от всех форм онкологических заболеваний кожи, однако 80% смертей в данной группе обусловлено именно меланомой. В 2014 году в России стандартизованный показатель смертности от меланомы кожи составил 1,51 на 100 000 населения. Заболеваемость меланомой кожи в РФ и многих странах мира неуклонно растет. По абсолютному приросту заболеваемости среди всех злокачественных опухолей меланома кожи занимает 2 место после рака легкого.Увеличение числа случаев заболеваемости меланомой диктует необходимость углубленного изучения биологии данной опухоли и ее взаимодействия с системойиммунобиологического надзора. Учитывая иммуногенность меланомы, важное значение имеет характер и степень иммунного ответа на опухоль. Поэтому одним из важных прогностических факторов течения меланомы является степень выраженности и субпопуляционный состав лимфоидной инфильтрации опухоли, которая также  имеет значение для подбора индивидуализированного лечения современными иммунотерапевтическими препаратами, в частности ипилимумабом, биомишенью для которого является супрессорный рецептор Т-лимфоцитов CTLA‑4.

Cutaneous melanoma is 1–4% of all cancers. Among all malignant skin tumors, melanoma has a special place, it accounts for about 4% of all forms of skin cancer, but 80% of deaths in the group of malignant tumors of the skin caused by melanoma. In 2014 in Russian Federation, the standardized death rate from melanoma of the skin was 1.51 per 100 000 population. The incidence of melanoma has been steadily growing in Russian Federation and many other countries. In absolute increase the incidence of all malignant tumors, skin melanoma is ranked 2nd after lung cancer. Increased incidence of melanoma necessitates in-depth study of the biology of this tumor and its interaction with the immunobiological control system. Considering the immunogenicity of melanoma, the importance of the nature of the immune response to growing tumor. Therefore, one of the most important prognostic factor of the disease in these patients is the severity and subpopulations of lymphoid infiltration of the tumor, which is also important for the selection of personalizedtreatments with modern immunotherapeutic drugs, such as ipilimumab, which is the biological target for T cell suppressor receptor CTLA- 4.

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The authors declare that there are no conflicts of interest present.