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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">tumors</journal-id><journal-title-group><journal-title xml:lang="ru">Malignant tumours</journal-title><trans-title-group xml:lang="en"><trans-title>Malignant tumours</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2224-5057</issn><issn pub-type="epub">2587-6813</issn><publisher><publisher-name>Rosoncoweb</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">tumors-282</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>ГЕПАТОЦЕЛЛЮЛЯРНЫЙ РАК  ПРОМЕЖУТОЧНОЙ СТАДИИ. BCLC B – ОФИЦИАЛЬНЫЕ РЕКОМЕНДАЦИИ, КАК СТРАТЕГИЯ БАЗИСНОГО ЛЕЧЕНИЯ И ТОЧКА ОТСЧЕТА В ОЦЕНКЕ ЭФФЕКТИВНОСТИ НОВЫХ ПОДХОДОВ</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бредер</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Breder</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бредер  Валерий Владимирович – кандидат медицинских наук, ведущий научный сотрудник отделения клинических биотехнологий, хирургическое отделение № 13 торако-абдоминального отдела</p></bio><email xlink:type="simple">vbreder@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лактионов</surname><given-names>К. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Laktionov</surname><given-names>K. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лактионов Константин Павлович – доктор медицинских наук, профессор,  ведущий научный сотрудник отделения клинических биотехнологий, хирургическое отделение № 13 торако-абдоминального отдела</p></bio><email xlink:type="simple">lkoskos@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Научно-исследовательский институт клинической онкологии, Российский онкологический научный центр имени Н.Н. Блохина</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>17</day><month>11</month><year>2016</year></pub-date><volume>0</volume><issue>4s1</issue><fpage>29</fpage><lpage>35</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бредер В.В., Лактионов К.П., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Бредер В.В., Лактионов К.П.</copyright-holder><copyright-holder xml:lang="en">Breder V.V., Laktionov K.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.malignanttumors.org/jour/article/view/282">https://www.malignanttumors.org/jour/article/view/282</self-uri><abstract><p>Представлен анализ Барселонской клинической классификации (BCLC) гепатоцеллюлярного рака (ГЦР). Подробно освещены лечебные рекомендации, предлагаемые BCLC для промежуточной стадии, рассмотрены современные мировые тенденции по внедрению эффективных  лечебных стратегий. Проведен анализ клинической гетерогенности промежуточной стадии (BCLC В), проблем диагностики и лечения. Подчеркнута важность стандартизованного алгоритма обследования для точной диагностики  промежуточной  стадии ГЦР. Рассмотрены перспективы оптимизации лечебных стратегий при BCLC В: поиск  и создание возможностей для радикального оперативного лечения, а также рациональное использование консервативных методов – химиоэмболизации и системной терапии – в лечении неоперабельных больных ГЦР.</p></abstract><kwd-group xml:lang="ru"><kwd>гепатоцеллюлярный рак</kwd><kwd>BCLC</kwd><kwd>ТАХЭ</kwd><kwd>цирроз печени</kwd><kwd>сорафениб</kwd><kwd>категория ALBI</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Siegel R. et al. Cancer statistics, 2014 // CA. Cancer J. Clin. 2014. Vol. 64, № 1. P. 9–29.</mixed-citation><mixed-citation xml:lang="en">Siegel R. et al. Cancer statistics, 2014 // CA. Cancer J. Clin. 2014. Vol. 64, № 1. P. 9–29.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ferlay J. et al. 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