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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">tumors</journal-id><journal-title-group><journal-title xml:lang="ru">Malignant tumours</journal-title><trans-title-group xml:lang="en"><trans-title>Malignant tumours</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2224-5057</issn><issn pub-type="epub">2587-6813</issn><publisher><publisher-name>Rosoncoweb</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">tumors-279</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>МЕТАСТАТИЧЕСКИЙ РАК  АНАЛЬНОГО КАНАЛА: ВОЗМОЖНОСТИ ХИМИОТЕРАПИИ И ПЕРСПЕКТИВЫ</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Федянин</surname><given-names>М. Ю.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Федянин Михаил Юрьевич – кандидат медицинских наук, старший научный сотрудник отделения клинической фармакологии  и химиотерапии</p></bio><email xlink:type="simple">fedianinmu@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Российский онкологический научный центр имени Н. Н. Блохина</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>17</day><month>11</month><year>2016</year></pub-date><volume>0</volume><issue>4s1</issue><fpage>14</fpage><lpage>19</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Федянин М.Ю., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Федянин М.Ю.</copyright-holder><copyright-holder xml:lang="en">Федянин М.Ю.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.malignanttumors.org/jour/article/view/279">https://www.malignanttumors.org/jour/article/view/279</self-uri><abstract><p>У 80–95% больных плоскоклеточный рак анального канала диагностируется в виде ранней или местно-распространенной стадии. Метастатическая болезнь выявляется только у 5–15 больных на момент постановки диагноза и 10–20% метастазы разовьются после окончания первичного химиолучевого лечения. В связи с этим, а также редкостью патологии доказательной базы по выбору системной терапии при метастазах рака анального канала в литературе крайне мало.</p><p>В данном  обзоре литературы мы разберём современные стандарты лечения метастатического плоскоклеточного рака анального канала и результаты исследований последних лет по введению в схемы лечения препаратов нового класса — таргетной терапии и иммунотерапии.</p><p> </p></abstract><kwd-group xml:lang="ru"><kwd>рак анального канала</kwd><kwd>химиотерапия</kwd><kwd>таргетная терапия</kwd><kwd>иммунотерапия</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Horner M., Ries L., Krapcho M., et al. 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