<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">tumors</journal-id><journal-title-group><journal-title xml:lang="ru">Malignant tumours</journal-title><trans-title-group xml:lang="en"><trans-title>Malignant tumours</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2224-5057</issn><issn pub-type="epub">2587-6813</issn><publisher><publisher-name>Rosoncoweb</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18027/2224-5057-2016-3-32-36</article-id><article-id custom-type="elpub" pub-id-type="custom">tumors-258</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL REPORTS</subject></subj-group></article-categories><title-group><article-title>Дифференциальная диагностика холангиокарцином внутрипечёночной локализации</article-title><trans-title-group xml:lang="en"><trans-title>Differential diagnosis intrahepatic cholangiocarcinoma localization</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>ИЩЕНКО</surname><given-names>Р. В.</given-names></name><name name-style="western" xml:lang="en"><surname>ISCHENKO</surname><given-names>R. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., заведующий 11 онкологическим отделением</p></bio><bio xml:lang="en"><p>MD, PhD, DSc, head of the Oncology Department 11</p></bio><email xlink:type="simple">ishenkorv@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>АНДРЕЕВА</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>ANDREEVA</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>заведующая патологоанатомическим отделением</p></bio><bio xml:lang="en"><p>head of the Pathology Department</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>ЯКОВЛЕВА</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>YAKOVLEVA</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач патологоанатомического отделения</p></bio><bio xml:lang="en"><p>physician pathology department</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>ИЩЕНКО</surname><given-names>К. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>ISHCHENKO</surname><given-names>K. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач патологоанатомического отделения</p></bio><bio xml:lang="en"><p>physician pathology department</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский областной онкологический диспансер</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Regional Oncological Center</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>15</day><month>10</month><year>2016</year></pub-date><volume>0</volume><issue>3</issue><fpage>32</fpage><lpage>36</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; ИЩЕНКО Р.В., АНДРЕЕВА М.А., ЯКОВЛЕВА Е.В., ИЩЕНКО К.Б., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">ИЩЕНКО Р.В., АНДРЕЕВА М.А., ЯКОВЛЕВА Е.В., ИЩЕНКО К.Б.</copyright-holder><copyright-holder xml:lang="en">ISCHENKO R.V., ANDREEVA M.A., YAKOVLEVA E.V., ISHCHENKO K.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.malignanttumors.org/jour/article/view/258">https://www.malignanttumors.org/jour/article/view/258</self-uri><abstract><p>На биопсийном и хирургическом материале наибольшую трудность в плане дифференциальной морфологической диагностики с метастазами аденокарцином различных локализаций представляют холангиоцеллюлярная карцинома (ХЦК) и гепатохолангиоцеллюлярный рак (ГХЦР). Пациенты в анамнезе не указывали на перенесенный в прошлом вирусный или паразитарный гепатит. Однако следует отметить, что в наших наблюдениях обе формы рака развивались на фоне крупноузлового цирроза печени.</p></abstract><trans-abstract xml:lang="en"><p>On biopsy and surgical material of greatest difficulty in terms of differential morphological diagnosis of metastatic adenocarcinoma of various localizations are cholangiocellular carcinoma (CCK) and gepatocholangiocellular cancer (GCCK). Patients no history of myocardial indicated last parasitic or viral hepatitis. However, it should be noted that our observations both forms of cancer developing on the background cirrhosis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>холлангиокарцинома</kwd><kwd>метастаз в печень</kwd><kwd>цирроз печени</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hollangiokartsinoma</kwd><kwd>metastasis to the liver</kwd><kwd>cirrhosis of the liver</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Welzel T. M., McGlynn K.A., Hsing A. W. et al. Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on the incidence of intra- and extrahepatic cholangiocarcinoma in the United States. J Natl Cancer Inst. 2006; Vol. 98: p. 873–875.</mixed-citation><mixed-citation xml:lang="en">Welzel T. M., McGlynn K.A., Hsing A. W. et al. Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on the incidence of intra- and extrahepatic cholangiocarcinoma in the United States. J Natl Cancer Inst. 2006; Vol. 98: p. 873–875.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">B., Komuta M., Roskams T., Gores G. J. Clinical diagnosis and staging of cholangiocarcinoma. Nat Rev Gastroenterol Hepatol. 2011; Vol. 8: p. 512–522.</mixed-citation><mixed-citation xml:lang="en">B., Komuta M., Roskams T., Gores G. J. Clinical diagnosis and staging of cholangiocarcinoma. Nat Rev Gastroenterol Hepatol. 2011; Vol. 8: p. 512–522.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Deoliveira M. L., Schulick R. D., Nimura Y. et al. New staging system and a registry for perihilar cholangiocarcinoma. Hepatology. 2011; Vol. 53: p.1363–1371.</mixed-citation><mixed-citation xml:lang="en">Deoliveira M. L., Schulick R. D., Nimura Y. et al. New staging system and a registry for perihilar cholangiocarcinoma. Hepatology. 2011; Vol. 53: p.1363–1371.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">DeOliveira M.L., Cunningham S. C., Cameron J. L. et al. Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution. Ann Surg. 2007; Vol. 245: p.755– 762.</mixed-citation><mixed-citation xml:lang="en">DeOliveira M.L., Cunningham S. C., Cameron J. L. et al. Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution. Ann Surg. 2007; Vol. 245: p.755– 762.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Blechacz B. G., G. J. Feldman: Sleisenger and Fordtran’s Gastrointestinal and Liver Disease. 9. Vol. 1. Saunders; 2010. Tumors of the Bile Ducts, Gallbladder, and Ampulla; pp. 1171–1176.</mixed-citation><mixed-citation xml:lang="en">Blechacz B. G., G. J. Feldman: Sleisenger and Fordtran’s Gastrointestinal and Liver Disease. 9. Vol. 1. Saunders; 2010. Tumors of the Bile Ducts, Gallbladder, and Ampulla; pp. 1171–1176.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Khan S. A., Davidson B. R., Goldin R. D. et al. Guidelines for the diagnosis and treatment of cholangiocarcinoma: an update. Gut. 2012; Vol.61: p.1657–69.</mixed-citation><mixed-citation xml:lang="en">Khan S. A., Davidson B. R., Goldin R. D. et al. Guidelines for the diagnosis and treatment of cholangiocarcinoma: an update. Gut. 2012; Vol.61: p.1657–69.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Everhart J. E., Ruhl C. E. Burden of digestive diseases in the United States Part III: Liver, biliary tract, and pancreas. Gastroenterology. 2009; Vol.136: p.1134–1144.</mixed-citation><mixed-citation xml:lang="en">Everhart J. E., Ruhl C. E. Burden of digestive diseases in the United States Part III: Liver, biliary tract, and pancreas. Gastroenterology. 2009; Vol.136: p.1134–1144.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Tyson G. L., El-Serag H. B. Risk factors forcholangiocarcinoma. Hepatology. 2011; Vol. 54: p.173–184.</mixed-citation><mixed-citation xml:lang="en">Tyson G. L., El-Serag H. B. Risk factors forcholangiocarcinoma. Hepatology. 2011; Vol. 54: p.173–184.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Shaib Y., El-Serag H. B. The epidemiology of cholangiocarcinoma. Semin Liver Dis. 2004; Vol. 24: p.115–125.</mixed-citation><mixed-citation xml:lang="en">Shaib Y., El-Serag H. B. The epidemiology of cholangiocarcinoma. Semin Liver Dis. 2004; Vol. 24: p.115–125.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Sripa B., Pairojkul C. Cholangiocarcinoma: lessons from Thailand. Curr Opin Gastroenterol. 2008; Vol. 24: p.349–356.</mixed-citation><mixed-citation xml:lang="en">Sripa B., Pairojkul C. Cholangiocarcinoma: lessons from Thailand. Curr Opin Gastroenterol. 2008; Vol. 24: p.349–356.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Khan S. A., Taylor-Robinson S.D., Toledano M. B. et al. Changing international trends in mortality rates for liver, biliary and pancreatic tumours. J Hepatol. 2002; Vol. 37: p.806–813. 12. Khan S. A., Toledano M. B., Taylor-Robinson S. D. Epidemiology, risk factors, and pathogenesis of cholangiocarcinoma. HPB (Oxford) 2008; Vol. 10: p.77–82.</mixed-citation><mixed-citation xml:lang="en">Khan S. A., Taylor-Robinson S.D., Toledano M. B. et al. Changing international trends in mortality rates for liver, biliary and pancreatic tumours. J Hepatol. 2002; Vol. 37: p.806–813. 12. Khan S. A., Toledano M. B., Taylor-Robinson S. D. Epidemiology, risk factors, and pathogenesis of cholangiocarcinoma. HPB (Oxford) 2008; Vol. 10: p.77–82.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">McGlynn K.A., Tarone R. E., El-Serag H.B. A comparison of trends in the incidence of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in the United States. Cancer Epidemiol Biomarkers Prev. 2006; Vol. 15: p. 1198–1203.</mixed-citation><mixed-citation xml:lang="en">McGlynn K.A., Tarone R. E., El-Serag H.B. A comparison of trends in the incidence of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in the United States. Cancer Epidemiol Biomarkers Prev. 2006; Vol. 15: p. 1198–1203.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Patel T. Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States. Hepatology. 2001; Vol. 33: p.1353–1357.</mixed-citation><mixed-citation xml:lang="en">Patel T. Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States. Hepatology. 2001; Vol. 33: p.1353–1357.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Patel T. Worldwide trends in mortality from biliary tractmalignancies. BMC Cancer. 2002; Vol. 2: p.10.</mixed-citation><mixed-citation xml:lang="en">Patel T. Worldwide trends in mortality from biliary tractmalignancies. BMC Cancer. 2002; Vol. 2: p.10.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Khan S. A., Emadossadaty S., Ladep N. G. et al. Rising trends in cholangiocarcinoma: Is the ICD classification system misleading us? Journal of Hepatology. 2012; Vol. 56: p.848– 854.</mixed-citation><mixed-citation xml:lang="en">Khan S. A., Emadossadaty S., Ladep N. G. et al. Rising trends in cholangiocarcinoma: Is the ICD classification system misleading us? Journal of Hepatology. 2012; Vol. 56: p.848– 854.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Razumilava N., Gores G. J. Classification, diagnosis, and management of cholangiocarcinoma. Clin Gastroenterol Hepatol. 2013; Vol. 11: p.13–21.</mixed-citation><mixed-citation xml:lang="en">Razumilava N., Gores G. J. Classification, diagnosis, and management of cholangiocarcinoma. Clin Gastroenterol Hepatol. 2013; Vol. 11: p.13–21.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Shin H. R., Oh J. K., Lim M. K. et al. Descriptive epidemiology of cholangiocarcinoma and clonorchiasis in Korea. J Korean Med Sci. 2010; Vol. 25: p. 1011–1016.</mixed-citation><mixed-citation xml:lang="en">Shin H. R., Oh J. K., Lim M. K. et al. Descriptive epidemiology of cholangiocarcinoma and clonorchiasis in Korea. J Korean Med Sci. 2010; Vol. 25: p. 1011–1016.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Huang M. H., Chen C. H., Yen C. M. et al. Relation of hepatolithiasis to helminthic infestation. J Gastroenterol Hepatol. 2005; Vol.20: p.141–146.</mixed-citation><mixed-citation xml:lang="en">Huang M. H., Chen C. H., Yen C. M. et al. Relation of hepatolithiasis to helminthic infestation. J Gastroenterol Hepatol. 2005; Vol.20: p.141–146.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Edil B. H., Cameron J. L., Reddy S. et al. Choledochal cyst disease in children and adults: a 30-year singleinstitution experience. J Am Coll Surg. 2008; Vol. 206: p1000–1005. discussion 1005–8.</mixed-citation><mixed-citation xml:lang="en">Edil B. H., Cameron J. L., Reddy S. et al. Choledochal cyst disease in children and adults: a 30-year singleinstitution experience. J Am Coll Surg. 2008; Vol. 206: p1000–1005. discussion 1005–8.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Mabrut J. Y., Bozio G., Hubert C., Gigot J. F. Management of congenital bile duct cysts. Dig Surg. 2010; Vol. 27: p 12–18.</mixed-citation><mixed-citation xml:lang="en">Mabrut J. Y., Bozio G., Hubert C., Gigot J. F. Management of congenital bile duct cysts. Dig Surg. 2010; Vol. 27: p 12–18.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
